Correlation between hepatitis B virus surface antigen level and alpha-fetoprotein in patients free of hepatocellular carcinoma or severe hepatitis

Journal of Medical Virology

Volumn 86, Issue 1, 2014, Pages 131-138

  Akuta, Norio ^a   Suzuki, Fumitaka ^a   Kobayashi, Mariko ^a   Hara, Tasuku ^a   Sezaki, Hitomi ^a   Suzuki, Yoshiyuki ^a   Hosaka, Tetsuya ^a   Kobayashi, Masahiro ^a   Saitoh, Satoshi ^a   Ikeda, Kenji ^a   Kumada, Hiromitsu ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

AFP; Genotype; HBcrAg; HBsAg; HBV; Hepatocellular carcinoma

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALPHA FETOPROTEIN BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HEPATITIS B; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; THROMBOCYTE COUNT;

HEPATITIS B VIRUS;

AFP; GENOTYPE; HBCRAG; HBSAG; HBV; HEPATOCELLULAR CARCINOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; INCIDENCE; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; YOUNG ADULT;

EID: 84887824693     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23790     Document Type: Article

References (43)

1. Akuta N, Suzuki F, Seko Y, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Hara T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kumada H. 2012. Complicated relationships of amino acid substitution in hepatitis C virus core region and IL28B genotype influencing hepatocarcinogenesis. Hepatology 56:2134-2141.
2. Alpert E, Feller ER. 1978. α-fetoprotein (AF) in benign liver disease. Gastroenterology 74:856-858.
3. Arase Y, Ikeda K, Suzuki F, Suzuki Y, Kobayashi M, Akuta N, Hosaka T, Sezaki H, Yatsuji H, Kawamura Y, Kobayashi M, Kumada H. 2007. Prolonged-interferon therapy reduces hepatocarcinogenesis in aged-patients with chronic hepatitis C. J Med Virol 79:1095-1102.
4. Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N. 2013. α-Fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology 58:1253-1262.
5. Bayati N, Silverman Al, Gordon SC. 1998. Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C. Am J Gastroenterol 93:2452-2456.
6. Bergstrand CG, Czar B. 1956. Demonstration of a new protein fraction in serum from the human fetus. Scand J Clin Lab Invest 8:174.
7. Bruix J, Sherman M. 2005. Practice guidelines committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology 42:1208-1236.
8. Brunetto MR, Moriconi F, Bonino F, Lau GK, Farci P, Yurdaydin C, Piratvisuth T, Luo K, Wang Y, Hadziyannis S, Wolf E, McCloud P, Batrla R, Marcellin P. 2009. Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology 49:1141-1150.
9. Brunetto MR, Oliveri F, Colombatto P, Moriconi F, Ciccorossi P, Coco B, Romagnoli V, Cherubini B, Moscato G, Maina AM, Cavallone D, Bonino F. 2010. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology 139:483-490.
10. Chan HL. 2012. Identifying hepatitis B carriers at low risk for hepatocellular carcinoma. Gastroenterology 142:1057-1060.
11. Chan HL, Wong VW, Wong GL, Tse CH, Chan HY, Sung JJ. 2010. A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B. Hepatology 52:1232-1241.
12. Chan HL, Thompson A, Martinot-Peignoux M, Piratvisuth T, Cornberg M, Brunetto MR, Tillmann HL, Kao JH, Jia JD, Wedemeyer H, Locarnini S, Janssen HL, Marcellin P. 2011. Hepatitis B surface antigen quantification: Why and how to use it in 2011-A core group report. J Hepatol 55:1121-1131.
13. Cheema AW, Hirschtritt T, Van Thiel DH. 2004. Markedly elevated alpha-fetoprotein levels without hepatocellular carcinoma. Hepatogastroenterology 51:1676-1678.
14. Chen DS, Sung JL. 1979. Relationship of hepatitis B surface antigen to serum alpha-fetoprotein in nonmalignant diseases of the liver. Cancer 44:984-992.
15. Chu CW, Hwang SJ, Luo JC, Lai CR, Tsay SH, Li CP, Wu JC, Chang FY, Lee SD. 2001. Clinical, virological, and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C. J Clin Gastroenterol 32:240-244.
16. Di Bisceglie AM, Hoofnagle JH. 1989. Elevations in serum alpha-fetoprotein levels in patients with chronic hepatitis B. Cancer 64:2117-2120.
17. Ebara M, Ohto M, Shinagawa T, Sugiura N, Kimura K, Matsutani S, Morita M, Saisho H, Tsuchiya Y, Okuda K. 1986. Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis. A study in 22 patients. Gastroenterology 90:289-298.
18. Elftherious N, Heathcote J, Thomas HC, Sherlock S. 1977. Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. J Clin Pathol 30:704-708.
19. Hosaka T, Suzuki F, Kobayashi M, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Akuta N, Suzuki Y, Saitoh S, Arase Y, Ikeda K, Kobayashi M, Kumada H. 2010. HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy. Liver Int 30:1461-1470.
20. Hu KQ, Esrailian E, Thompson K, Chase R, Kyulo N, Hassen M, Abdelhalim F, Hillebrand DJ, Runyon BA. 2002. Hepatic steatosis is associated with disease progression of chronic hepatitis C: A large cohort study in the United States. Hepatology 36:349A.
21. Hu KQ, Kyulo N, Lim N, Elhazin B, Hillebrand DJ, Bock T. 2004. Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma. Am J Gastroenterol 99:860-865.
22. Ikeda K, Arase Y, Kawamura Y, Yatsuji H, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Saitoh S, Suzuki F, Suzuki Y, Kumada H. 2009. Necessities of interferon therapy in elderly patients with chronic hepatitis C. Am J Med 122:479-486.
23. Jaroszewicz J, Calle Serrano B, Wursthorn K, Deterding K, Schlue J, Raupach R, Flisiak R, Bock CT, Manns MP, Wedemeyer H, Cornberg M. 2010. Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective. J Hepatol 52:514-522.
24. Johnson PJ. 2001. The role of serum alpha-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma. Clin Liv Dis 5:145-159.
25. Kew MC, Purves LR, Bersohn I. 1973. Serum alpha-fetoprotein levels in acute viral hepatitis. Gut 14:939-942.
26. Kimura T, Rokuhara A, Sakamoto Y, Yagi S, Tanaka E, Kiyosawa K, Maki N. 2002. Sensitive enzyme immunoassay for hepatitis B virus core-related antigens and their correlation to virus load. J Clin Microbiol 40:439-445.
27. Kimura T, Ohno N, Terada N, Rokuhara A, Matsumoto A, Yagi S, Tanaka E, Kiyosawa K, Ohno S, Maki N. 2005. Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem 280:21713-21719.
28. Kobayashi M, Arase Y, Ikeda K, Tsubota A, Suzuki Y, Saitoh S, Kobayashi M, Suzuki F, Akuta N, Someya T, Matsuda M, Sato J, Kumada H. 2002. Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C. J Gastroenterol 37:35-39.
29. Kumada T, Toyoda H, Tada T, Kiriyama S, Tanikawa M, Hisanaga Y, Kanamori A, Niinomi T, Yasuda S, Andou Y, Yamamoto K, Tanaka J. 2013. Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: A propensity score analysis. J Hepatol 58:427-433.
30. Liaw YF. 2011. Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: A review. Hepatology 54:E1-E9.
31. Martinot-Peignoux M, Lada O, Cardoso AC, Lapalus M, Boyer N, Ripault MP, Asselah T, Marcellin P. 2010. Quantitative HBsAg: A new specific marker for the diagnosis of HBsAg inactive carriage. Hepatology 52:992A.
32. Martinot-Peignoux M, Carvalho-Filho R, Lapalus M, Netto-Cardoso AC, Lada O, Batrla R, Krause F, Asselah T, Marcellin P. 2013. Hepatitis B surface antigen serum level is associated with fibrosis severity in treatment-naïve, E antigen-positive patients. J Hepatol 58:1089-1095.
33. Moucari R, Mackiewicz V, Lada O, Ripault MP, Castelnau C, Martinot-Peignoux M, Dauvergne A, Asselah T, Boyer N, Bedossa P, Valla D, Vidaud M, Nicolas-Chanoine MH, Marcellin P. 2009. Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology 49:1151-1157.
34. Nguyen T, Thompson AJ, Bowden S, Croagh C, Bell S, Desmond PV, Levy M, Locarnini SA. 2010. Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia. J Hepatol 52:508-513.
35. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Endo Y, Nagataki S. 1993. Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 328:1802-1806.
36. Seto WK, Wong DK, Fung J, Ip PP, Yuen JC, Hung IF, Lai CL, Yuen MF. 2012. High hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis B. PLoS ONE 7:e43087.
37. Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Morita M, Saisho H, Tsuchiya Y, Saotome N, Karasawa E, Miki M. 1984. Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography. A study in 51 patients. Gastroenterology 86:495-502.
38. Silver HK, Gold P, Shuster J, Javitt NB, Freedman SO, Finlayson ND. 1974. Alpha 1-fetoprotein in chronic liver disease. N Engl J Med 291:506-508.
39. Suzuki F, Miyakoshi H, Kobayashi M, Kumada H. 2009. Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients. J Med Virol 81:27-33.
40. Tseng TC, Liu CJ, Yang HC, Su TH, Wang CC, Chen CL, Kuo SF, Liu CH, Chen PJ, Chen DS, Kao JH. 2012. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology 142:1140-1149.
41. Viola LA, Barrison IG, Coleman JC, Paradinas FJ, Fluker JL, Evans BA, Murray-Lyon IM. 1981. Natural history of liver disease in chronic hepatitis B surface antigen carriers. Survey of 100 patients from Great Britain. Lancet 2:1156-1159.
42. Wong DK, Tanaka Y, Lai CL, Mizokami M, Fung J, Yuen MF. 2007. Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J Clin Microbiol 45:3942-3947.
43. Yao FY. 2003. Dramatic reduction of the alpha-fetoprotein level after lamivudine treatment of patients with chronic hepatitis B virus infection and cirrhosis. J Clin Gastroenterol 36:440-442.