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Volumn 155, Issue 1-2, 2013, Pages 43-46

Acute myeloid leukemia and novel biological treatments: Monoclonal antibodies and cell-based gene-modified immune effectors

Author keywords

Acute myeloid leukemia (AML); Chimeric antigen receptor (CAR); Cytokine induced killer (CIK) cells; Gene therapy; Immunotherapy; Monoclonal antibody (mAb)

Indexed keywords

ANTINEOPLASTIC AGENT; BLINATUMOMAB; CD135 ANTIGEN; CD33 ANTIGEN; CD44V6 ANTIGEN; CSL 360; CYTOTOXIC AGENT; DT 388 IL3; GEMTUZUMAB OZOGAMICIN; IMC EB10; LEUKEMIA ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 84887820522     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2013.09.013     Document Type: Review
Times cited : (18)

References (41)
  • 1
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H., Estey E.H., Amadori S., Appelbaum F.R., Buchner T., Burnett A.K., et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6
  • 2
    • 84868129082 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel
    • Creutzig U., van den Heuvel-Eibrink M.M., Gibson B., Dworzak M.N., Adachi S., de Bont E., et al. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood 2012, 120:3187-3205.
    • (2012) Blood , vol.120 , pp. 3187-3205
    • Creutzig, U.1    van den Heuvel-Eibrink, M.M.2    Gibson, B.3    Dworzak, M.N.4    Adachi, S.5    de Bont, E.6
  • 3
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997, 3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 4
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert K., Takenaka K., Lechman E.R., Waldron L., Nilsson B., van Galen P., et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 2011, 17:1086-1093.
    • (2011) Nat Med , vol.17 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3    Waldron, L.4    Nilsson, B.5    van Galen, P.6
  • 5
    • 80054037204 scopus 로고    scopus 로고
    • Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates
    • FitzGerald D.J., Wayne A.S., Kreitman R.J., Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Res 2011, 71:6300-6309.
    • (2011) Cancer Res , vol.71 , pp. 6300-6309
    • FitzGerald, D.J.1    Wayne, A.S.2    Kreitman, R.J.3    Pastan, I.4
  • 6
    • 79952282655 scopus 로고    scopus 로고
    • Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells
    • Majeti R. Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene 2011, 30:1009-1019.
    • (2011) Oncogene , vol.30 , pp. 1009-1019
    • Majeti, R.1
  • 8
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
    • Hamann P.R., Hinman L.M., Hollander I., Beyer C.F., Lindh D., Holcomb R., et al. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem 2002, 13:47-58.
    • (2002) Bioconjug Chem , vol.13 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3    Beyer, C.F.4    Lindh, D.5    Holcomb, R.6
  • 9
    • 51649089123 scopus 로고    scopus 로고
    • Gemtuzumab-ozogamicin in combination with fludarabine, cytarabine, idarubicin (FLAI-GO) as induction therapy in CD33-positive AML patients younger than 65 years
    • Candoni A., Martinelli G., Toffoletti E., Chiarvesio A., Tiribelli M., Malagola M., et al. Gemtuzumab-ozogamicin in combination with fludarabine, cytarabine, idarubicin (FLAI-GO) as induction therapy in CD33-positive AML patients younger than 65 years. Leuk Res 2008, 32:1800-1808.
    • (2008) Leuk Res , vol.32 , pp. 1800-1808
    • Candoni, A.1    Martinelli, G.2    Toffoletti, E.3    Chiarvesio, A.4    Tiribelli, M.5    Malagola, M.6
  • 10
    • 77957711298 scopus 로고    scopus 로고
    • Preliminary results of Southwest Oncology Group Study S0106: an international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia
    • Petersdorf S., Kopecky K., Stuart R.K. Preliminary results of Southwest Oncology Group Study S0106: an international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia. Blood 2009, 114(abstr 790):326.
    • (2009) Blood , vol.114 , Issue.ABSTR 790 , pp. 326
    • Petersdorf, S.1    Kopecky, K.2    Stuart, R.K.3
  • 11
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study
    • Castaigne S., Pautas C., Terre C., Raffoux E., Bordessoule D., Bastie J.N., et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet 2012, 379:1508-1516.
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terre, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.N.6
  • 12
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • Burnett A.K., Russell N.H., Hills R.K., Kell J., Freeman S., Kjeldsen L., et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol 2012, 30:3924-3931.
    • (2012) J Clin Oncol , vol.30 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Kell, J.4    Freeman, S.5    Kjeldsen, L.6
  • 13
    • 84875423224 scopus 로고    scopus 로고
    • Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group
    • Kaspers G.J., Zimmermann M., Reinhardt D., Gibson B.E., Tamminga R.Y., Aleinikova O., et al. Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group. J Clin Oncol 2013, 31:599-607.
    • (2013) J Clin Oncol , vol.31 , pp. 599-607
    • Kaspers, G.J.1    Zimmermann, M.2    Reinhardt, D.3    Gibson, B.E.4    Tamminga, R.Y.5    Aleinikova, O.6
  • 14
    • 84871491706 scopus 로고    scopus 로고
    • Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp M.S., Gokbuget N., Zugmaier G., Degenhard E., Goebeler M.E., Klinger M., et al. Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 2012, 120:5185-5187.
    • (2012) Blood , vol.120 , pp. 5185-5187
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3    Degenhard, E.4    Goebeler, M.E.5    Klinger, M.6
  • 15
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
    • Aigner M., Feulner J., Schaffer S., Kischel R., Kufer P., Schneider K., et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia 2013, 27:1107-1115.
    • (2013) Leukemia , vol.27 , pp. 1107-1115
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3    Kischel, R.4    Kufer, P.5    Schneider, K.6
  • 16
    • 84859899567 scopus 로고    scopus 로고
    • Acute myeloid leukemia stem cells and CD33-targeted immunotherapy
    • Walter R.B., Appelbaum F.R., Estey E.H., Bernstein I.D. Acute myeloid leukemia stem cells and CD33-targeted immunotherapy. Blood 2012, 119:6198-6208.
    • (2012) Blood , vol.119 , pp. 6198-6208
    • Walter, R.B.1    Appelbaum, F.R.2    Estey, E.H.3    Bernstein, I.D.4
  • 17
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan C.T., Upchurch D., Szilvassy S.J., Guzman M.L., Howard D.S., Pettigrew A.L., et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia 2000, 14:1777-1784.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3    Guzman, M.L.4    Howard, D.S.5    Pettigrew, A.L.6
  • 18
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L., Lee E.M., Ramshaw H.S., Busfield S.J., Peoppl A.G., Wilkinson L., et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell 2009, 5:31-42.
    • (2009) Cell Stem Cell , vol.5 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3    Busfield, S.J.4    Peoppl, A.G.5    Wilkinson, L.6
  • 20
    • 39749148257 scopus 로고    scopus 로고
    • Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia
    • Frankel A., Liu J.S., Rizzieri D., Hogge D. Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia. Leuk Lymphoma 2008, 49:543-553.
    • (2008) Leuk Lymphoma , vol.49 , pp. 543-553
    • Frankel, A.1    Liu, J.S.2    Rizzieri, D.3    Hogge, D.4
  • 21
    • 77649225962 scopus 로고    scopus 로고
    • Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells
    • Stein C., Kellner C., Kugler M., Reiff N., Mentz K., Schwenkert M., et al. Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells. Br J Haematol 2010, 148:879-889.
    • (2010) Br J Haematol , vol.148 , pp. 879-889
    • Stein, C.1    Kellner, C.2    Kugler, M.3    Reiff, N.4    Mentz, K.5    Schwenkert, M.6
  • 23
    • 33646432479 scopus 로고    scopus 로고
    • IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples
    • Piloto O., Nguyen B., Huso D., Kim K.T., Li Y., Witte L., et al. IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples. Cancer Res 2006, 66:4843-4851.
    • (2006) Cancer Res , vol.66 , pp. 4843-4851
    • Piloto, O.1    Nguyen, B.2    Huso, D.3    Kim, K.T.4    Li, Y.5    Witte, L.6
  • 24
    • 84862020736 scopus 로고    scopus 로고
    • Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia
    • Hofmann M., Grosse-Hovest L., Nubling T., Pyz E., Bamberg M.L., Aulwurm S., et al. Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia. Leukemia 2012, 26:1228-1237.
    • (2012) Leukemia , vol.26 , pp. 1228-1237
    • Hofmann, M.1    Grosse-Hovest, L.2    Nubling, T.3    Pyz, E.4    Bamberg, M.L.5    Aulwurm, S.6
  • 25
    • 44049104095 scopus 로고    scopus 로고
    • Graft-versus-host disease after donor leukocyte infusions: presentation and management
    • Frey N.V., Porter D.L. Graft-versus-host disease after donor leukocyte infusions: presentation and management. Best Pract Res Clin Haematol 2008, 21:205-222.
    • (2008) Best Pract Res Clin Haematol , vol.21 , pp. 205-222
    • Frey, N.V.1    Porter, D.L.2
  • 26
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G., Waks T., Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U S A 1989, 86:10024-10028.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 27
    • 84885845993 scopus 로고    scopus 로고
    • Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells
    • Maher J. Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells. ISRN Oncol 2012, 2012:278093.
    • (2012) ISRN Oncol , vol.2012 , pp. 278093
    • Maher, J.1
  • 29
    • 77952420345 scopus 로고    scopus 로고
    • Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
    • Peinert S., Prince H.M., Guru P.M., Kershaw M.H., Smyth M.J., Trapani J.A., et al. Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther 2010, 17:678-686.
    • (2010) Gene Ther , vol.17 , pp. 678-686
    • Peinert, S.1    Prince, H.M.2    Guru, P.M.3    Kershaw, M.H.4    Smyth, M.J.5    Trapani, J.A.6
  • 30
    • 84887825923 scopus 로고    scopus 로고
    • Co-expression of a suicide gene in CAR-redirected T cells enables the safe targeting of CD44v6 for leukemia and myeloma eradication
    • Casucci M., Nicolis di Robilant B., Falcone L., Camisa B., Genovese P., Gentner B., et al. Co-expression of a suicide gene in CAR-redirected T cells enables the safe targeting of CD44v6 for leukemia and myeloma eradication. Blood ASH 2013.
    • (2013) Blood ASH
    • Casucci, M.1    Nicolis di Robilant, B.2    Falcone, L.3    Camisa, B.4    Genovese, P.5    Gentner, B.6
  • 31
    • 34247571007 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study
    • Rupp U., Schoendorf-Holland E., Eichbaum M., Schuetz F., Lauschner I., Schmidt P., et al. Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study. Anti-cancer drugs 2007, 18:477-485.
    • (2007) Anti-cancer drugs , vol.18 , pp. 477-485
    • Rupp, U.1    Schoendorf-Holland, E.2    Eichbaum, M.3    Schuetz, F.4    Lauschner, I.5    Schmidt, P.6
  • 32
    • 77951691641 scopus 로고    scopus 로고
    • Cytokine-induced NK-like T cells: from bench to bedside
    • Linn Y.C., Hui K.M. Cytokine-induced NK-like T cells: from bench to bedside. J Biomed Biotechnol 2010, 2010:435745.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 435745
    • Linn, Y.C.1    Hui, K.M.2
  • 33
    • 34548801834 scopus 로고    scopus 로고
    • Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study
    • Introna M., Borleri G., Conti E., Franceschetti M., Barbui A.M., Broady R., et al. Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study. Haematologica 2007, 92:952-959.
    • (2007) Haematologica , vol.92 , pp. 952-959
    • Introna, M.1    Borleri, G.2    Conti, E.3    Franceschetti, M.4    Barbui, A.M.5    Broady, R.6
  • 34
    • 84876177658 scopus 로고    scopus 로고
    • A Phase II study of sequential administration of DLI and Cytokine Induced Killer (CIK) cells in patients with hematologic malignancies relapsing after allogeneic hematopoietic stem cell transplantation: preliminary results
    • Introna M., Algarotti A., Micò C., Grassi A., Pievani A., Borleri G., et al. A Phase II study of sequential administration of DLI and Cytokine Induced Killer (CIK) cells in patients with hematologic malignancies relapsing after allogeneic hematopoietic stem cell transplantation: preliminary results. Blood (ASH Annual Meeting Abstracts) 2011, 118:657.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 657
    • Introna, M.1    Algarotti, A.2    Micò, C.3    Grassi, A.4    Pievani, A.5    Borleri, G.6
  • 35
    • 78649899281 scopus 로고    scopus 로고
    • Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors
    • Marin V., Pizzitola I., Agostoni V., Attianese G.M., Finney H., Lawson A., et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica 2010, 95:2144-2152.
    • (2010) Haematologica , vol.95 , pp. 2144-2152
    • Marin, V.1    Pizzitola, I.2    Agostoni, V.3    Attianese, G.M.4    Finney, H.5    Lawson, A.6
  • 36
    • 84876163922 scopus 로고    scopus 로고
    • Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
    • Tettamanti S., Marin V., Pizzitola I., Magnani C.F., Giordano Attianese G.M., Cribioli E., et al. Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. Br J Haematol 2013, 161:389-401.
    • (2013) Br J Haematol , vol.161 , pp. 389-401
    • Tettamanti, S.1    Marin, V.2    Pizzitola, I.3    Magnani, C.F.4    Giordano Attianese, G.M.5    Cribioli, E.6
  • 37
    • 84875138464 scopus 로고    scopus 로고
    • Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
    • Hackett P.B., Largaespada D.A., Switzer K.C., Cooper L.J. Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. Transl Res 2013, 161:265-283.
    • (2013) Transl Res , vol.161 , pp. 265-283
    • Hackett, P.B.1    Largaespada, D.A.2    Switzer, K.C.3    Cooper, L.J.4
  • 38
    • 77950501752 scopus 로고    scopus 로고
    • Safer CARS
    • Heslop H.E. Safer CARS. Mol Ther 2010, 18:661-662.
    • (2010) Mol Ther , vol.18 , pp. 661-662
    • Heslop, H.E.1
  • 40
    • 34748881184 scopus 로고    scopus 로고
    • Redirected activity of human antitumor chimeric immune receptors is governed by antigen and receptor expression levels and affinity of interaction
    • Turatti F., Figini M., Balladore E., Alberti P., Casalini P., Marks J.D., et al. Redirected activity of human antitumor chimeric immune receptors is governed by antigen and receptor expression levels and affinity of interaction. J Immunother 2007, 30:684-693.
    • (2007) J Immunother , vol.30 , pp. 684-693
    • Turatti, F.1    Figini, M.2    Balladore, E.3    Alberti, P.4    Casalini, P.5    Marks, J.D.6
  • 41
    • 33947633597 scopus 로고    scopus 로고
    • T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
    • Hombach A.A., Schildgen V., Heuser C., Finnern R., Gilham D.E., Abken H. T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunol 2007, 178:4650-4657.
    • (2007) J Immunol , vol.178 , pp. 4650-4657
    • Hombach, A.A.1    Schildgen, V.2    Heuser, C.3    Finnern, R.4    Gilham, D.E.5    Abken, H.6


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