Rapid access to spirocyclic oxindole alkaloids: Application of the asymmetric palladium-catalyzed [3 + 2] trimethylenemethane cycloaddition

Journal of the American Chemical Society

Volumn 135, Issue 44, 2013, Pages 16720-16735

  Trost, Barry M ^a   Bringley, Dustin A ^a,b   Zhang, Ting ^a,b   Cramer, Nicolai ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; BICYCLIC RING SYSTEM; DIASTEREO- AND ENANTIOSELECTIVITY; INTRAMOLECULAR MICHAEL ADDITION; QUANTITATIVE YIELDS; RADICAL CYCLIZATIONS; SECONDARY METABOLITES; TRIMETHYLENEMETHANE;

CHEMISTRY; SYNTHESIS (CHEMICAL);

ADDITION REACTIONS;

ALKALOID; ANTHELMINTIC AGENT; MARCFORTINE B; MARCFORTINE C; NATURAL PRODUCT; OXINDOLE; PALLADIUM; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CARBOXYLATION; CATALYSIS; CHIRALITY; CYCLIZATION; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; MICHAEL ADDITION; NONHUMAN; OXIDATION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ALKALOIDS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INDOLE ALKALOIDS; INDOLES; INDOLIZINES; METHANE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PALLADIUM; SPIRO COMPOUNDS;

EID: 84887786064     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja409013m     Document Type: Article

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