Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats

Reproductive Biology and Endocrinology

Volumn 11, Issue 1, 2013, Pages

  Xia, Fangzhen ^a   Xu, Xiao ^a   Zhai, Hualing ^a   Meng, Ying ^a   Zhang, Huixin ^a   Du, Shichun ^a   Xu, Hui ^a   Wu, Hui ^a   Lu, Yingli ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Hyperinsulinemic euglycemic clamp; Insulin resistance; Isotopic trace; Metabolic kinetics; Orchidectomy

Indexed keywords

GLUCOSE; GLYCEROL; INSULIN; PYRUVIC ACID; TESTOSTERONE; TESTOSTERONE PROPIONATE; TRANSCRIPTION FACTOR FKHR;

ADULT; ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CASTRATION; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN INFUSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; ORCHIECTOMY; TESTOSTERONE BLOOD LEVEL;

RATTUS;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CASTRATION; ESTROGENS; FASTING; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; KINETICS; LIVER; MALE; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE;

EID: 84887773479     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-11-106     Document Type: Article

References (28)

1. Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European male aging study. J Clin Endocrinol Metab 2008, 93(7):2737-2745. 10.1210/jc.2007-1972, 18270261.
2. Shelton JB, Rajfer J. Androgen Deficiency in Aging and Metabolically Challenged Men. Urol Clin N Am 2012, 39(1):63-75.
3. Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab 2011, 96(8):2341-2353. 10.1210/jc.2011-0118, 21646372.
4. Corona G, Monami M, Rastrelli G, Aversa A, Tishova Y, Saad F, Lenzi A, Forti G, Mannucci E, Maggi M. Testosterone and Metabolic Syndrome: A Meta-Analysis Study. J Sex Med 2011, 8(1):272-283. 10.1111/j.1743-6109.2010.01991.x, 20807333.
5. Nigro N, Christ-Crain M. Testosterone treatment in the aging male: myth or reality?. Swiss Med Wkly 2012, 19(142):w13539.
6. Morimoto S, Fernandez-Mejia C, Romero-Navarro G, Morales-Peza N, Díaz-Sánchez V. Testosterone effect on insulin content, messenger ribonucleic acid levels, promoter activity, and secretion in the rat. Endocrinology 2001, 142(4):1442-1447. 10.1210/en.142.4.1442, 11250923.
7. Christoffersen B, Raun K, Svendsen O, Fledelius C, Golozoubova V. Evalution of the castrated male Sprague-Dawley rat as a model of the metabolic syndrome and type 2 diabetes. Int J Obes (Lond) 2006, 30(8):1288-1297. 10.1038/sj.ijo.0803261, 16505834.
8. Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 1982, 31(11):957-963. 10.2337/diacare.31.11.957, 6757014.
9. Zhai H-L, Wu H, Xu H, Weng P, Xia F-Z, Chen Y, Lu Y-L. Trace glucose and lipid metabolism in high androgen and high-fat diet induced polycystic ovary syndrome rats. Reprod Biol Endocrinol 2012, 10:5. 10.1186/1477-7827-10-5, 3278365, 22276997.
10. Guo ZK, Nielson S, Buergera B, Jensen MD. Free fatty acid turnover measured using ultralow doses of [U-13C]palmitate. J Lipid Res 1997, 38(9):1888-1895.
11. Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab 2003, 284(1):E55-E69.
12. STEELE R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 1959, 82(25):420-430.
13. Smith MR. Changes in fat and lean body mass during androgendeprivation therapy for prostate cancer. Urology 2004, 63(4):742-745. 10.1016/j.urology.2003.10.063, 15072892.
14. Inoue T, Zakikhani M, David S, Algire C, Blouin MJ, Pollak M. Effects of Castration on Insulin Levels and Glucose Tolerance in the Mouse Differ From Those in Man. Prostate 2010, 70(15):1628-1635. 10.1002/pros.21198, 20564323.
15. Vermeulen A. Declining androgens with age - an overview. Androgens and the ageing male 1996, 3-14. New York: Parthenon Publishing, Oddens B, Vermeulen A.
16. Vanderschueren D, Jans I, Van Herck E. Time-related increase of biochemical markers of bone turnover in androgen-deficient male rats. Bone Miner 1994, 26(2):123-131. 10.1016/S0169-6009(08)80057-8, 7994184.
17. Erben RG, Erberle J, Stahr K, Goldberg M. Androgen deficiency induces high turnover osteopenia in aged male rats: A sequential histomorphometric study. JBMR 2000, 15(6):1085-1098.
18. Gill RK, Turner RT, Wronski TJ, Bell NH. Orcidectomy markedly reduces the concentration of the three isomers of transforming growth factor B in rat bone and reduction is prevented by testosterone. Endocrinology 1998, 139(2):546-550. 10.1210/en.139.2.546, 9449623.
19. Simon D, Preziosi P, Barrett-Connor E, Roger M, Saint-Paul M, Nahoul K, Papoz L. Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study. Diabetologia 1992, 35(2):173-177. 10.1007/BF00402551, 1547923.
20. Haffner SM, Valdez RA, Mykkänen L, Stern MP, Katz MS. Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 1994, 43(5):599-603. 10.1016/0026-0495(94)90202-X, 8177048.
21. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 2002, 51(9):2734-2741. 10.2337/diabetes.51.9.2734, 12196466.
22. Qureshi K, Abrams GA. Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol 2007, 13(26):3540-3553.
23. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 1996, 98(2):378-385. 10.1172/JCI118803, 507441, 8755648.
24. Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 1991, 254(5031):573-576. 10.1126/science.1948033, 1948033.
25. VAUGHAN M. The production and release of glycerol by adipose tissue incubated in vitro. J Biol Chem 1962, 237:3354-3358.
26. Defronzo RA. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009, 58(4):773-795. 10.2337/db09-9028, 2661582, 19336687.
27. Ferrannini E, Simonson DC, Katz LD, Reichard G, Bevilacqua S, Barrett EJ, Olsson M, DeFronzo RA. The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism 1988, 37(1):79-85. 10.1016/0026-0495(88)90033-9, 3275860.
28. Guo Z, Zhou L. Muscle type-dependent responses to insulin in intramyocellular triglyceride turnover in obese rats. Obes Res 2005, 13(12):2081-2087. 10.1038/oby.2005.258, 16421341.