What Is the Role of Medications in Late Life Depression?

Psychiatric Clinics of North America

Volumn 36, Issue 4, 2013, Pages 597-605

  Kok, Rob M ^a  

^a PARNASSIA PSYCHIATRIC INSTITUTE   (Netherlands)

Author keywords

Antidepressant; Efficacy; Side effects; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; CARBAMAZEPINE; FLUOXETINE; HERBACEOUS AGENT; LAMOTRIGINE; LITHIUM; MOOD STABILIZER; NORTRIPTYLINE; PLACEBO; PSYCHOSTIMULANT AGENT; SEROTONIN UPTAKE INHIBITOR; TERTIARY AMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

AGITATION; ANOREXIA; BIPOLAR DEPRESSION; BLEEDING; CARDIOVASCULAR DISEASE; DEMENTIA; DEPRESSION; DIARRHEA; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG OVERDOSE; DRUG RESPONSE; DRUG SAFETY; DRUG USE; ELECTROCONVULSIVE THERAPY; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPERICUM PERFORATUM; INSOMNIA; LATE LIFE DEPRESSION; MAINTENANCE THERAPY; MAJOR DEPRESSION; MENTAL DETERIORATION; NAUSEA; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; REMISSION; REVIEW; SEDATION; SEXUAL DYSFUNCTION; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESISTANT DEPRESSION; UNSPECIFIED SIDE EFFECT; URINE RETENTION; VITAL SIGN; WEIGHT GAIN; XEROSTOMIA;

ANTIDEPRESSANT; EFFICACY; SIDE EFFECTS; TREATMENT;

AGE FACTORS; AGED; ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 84887607517     PISSN: 0193953X     EISSN: 15583147     Source Type: Journal    
DOI: 10.1016/j.psc.2013.08.006     Document Type: Review

References (37)

1. Barry L.C., Abou J.J., Simen A.A., et al. Under-treatment of depression in older persons. JAffect Disord 2012, 136:789-796.
2. Pinquart M., Duberstein P.R., Lyness J.M. Treatments for later-life depressive conditions: a meta-analytic comparison of pharmacotherapy and psychotherapy. Am J Psychiatry 2006, 163:1493-1501.
3. Gum A.M., Arean P.A., Hunkeler E., et al. Depression treatment preferences in older primary care patients. Gerontologist 2006, 46:14-22.
4. Pollock B.G. Pharmacokinetics and pharmacodynamics in late life. Late-life depression 2004, 185-191. Oxford University Press, New York. S.P. Roose, H.A. Sackeim (Eds.).
5. Roose S.P., Sackheim H.A. Antidepressant medication for the treatment of late-life depression. Late-life depression 2004, 192-202. Oxford University Press, New York. S.P. Roose, H.A. Sackeim (Eds.).
6. Gerson S.C., Plotkin D.A., Jarvik L.F. Antidepressant drug studies, 1964 to 1986: empirical evidence for aging patients. JClin Psychopharmacol 1988, 8:311-322.
7. Kok R.M., Heeren T.J., Nolen W.A. Efficacy of treatment in older depressed patients: a systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. JAffect Disord 2012, 141:103-115.
8. Mittmann N., Herrmann N., Einarson T.R., et al. The efficacy, safety and tolerability of antidepressants in late life depression: a meta-analysis. JAffect Disord 1997, 46:191-217.
9. McCusker J., Cole M., Keller E., et al. Effectiveness of treatments of depression in older ambulatory patients. Arch Intern Med 1998, 158:705-712.
10. Katona C., Livingston G. How well do antidepressants work in older people? A systematic review of number needed to treat. JAffect Disord 2002, 69:47-52.
11. Wilson K., Mottram P., Sivanranthan A., et al. Antidepressant versus placebo for depressed elderly. Cochrane Database Syst Rev 2001, (1). CD000561.
12. Taylor W.D., Doraiswamy P.M. Asystematic review of antidepressant placebo-controlled trials for geriatric depression: limitations of current data and directions for the future. Neuropsychopharmacology 2004, 29:2285-2299.
13. Nelson J.C., Delucchi K., Schneider L.S. Efficacy of second generation antidepressants in late-life depression: a meta-analysis of the evidence. Am J Geriatr Psychiatry 2008, 16:558-567.
14. Sneed J.R., Rutherford B.R., Rindskopf D., et al. Design makes a difference; a meta-analysis of antidepressant response rates in placebo-controlled versus comparator trails in late-life depression. Am J Geriatr Psychiatry 2008, 16:65-73.
15. Williams J.W., Mulrow C.D., Chiquette E., et al. Asystematic review of newer pharmacotherapy's for depression in adults: evidence report summary. Ann Intern Med 2000, 132:743-756.
16. Gildengers A.G., Houck P.R., Mulsant B.H., et al. Course and rate of antidepressant response in the very old. JAffect Disord 2002, 69:177-184.
17. Taylor D., Meader N., Bird V., et al. Pharmacological interventions for people with depression and chronic physical health problems; systematic review and meta-analyses of safety and efficacy. Br J Psychiatry 2011, 198:179-188.
18. Mukai Y., Tampi R.R. Treatment of depression in the elderly: a review of the recent literature on the efficacy of single- versus dual-action antidepressants. Clin Ther 2009, 31:945-961.
19. Anderson I.M. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. JAffect Disord 2000, 58:19-36.
20. Kirsch I., Deacon B.J., Huedo-Medina T.B., et al. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 2008, 5:e45.
21. Bains J., Birks J.S., Dening T.R. The efficacy of antidepressants in the treatment of depression in dementia. Cochrane Database Syst Rev 2002, (4). CD003944.
22. Nelson J.C., Devanand D.P. Asystematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. JAm Geriatr Soc 2011, 59:577-585.
23. Banerjee S., Hellier J., Dewey M., et al. Sertraline or mirtazapine for depression indementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 2011, 378:403-411.
24. Sink K.M., Holden K.F., Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA 2005, 293:596-608.
25. Wilson K., Mottram P. Acomparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: a meta-analysis. Int J Geriatr Psychiatry 2004, 19:754-762.
26. Logan I.C., Witham M.D. Efficacy of treatment for orthostatic hypotension: a systematic review. Age Ageing 2012, 41:587-594.
27. Kok R.M., Nolen W.A., Heeren T.J. Outcome of late-life depression after 3 years of sequential treatment. Acta Psychiatr Scand 2009, 119:274-281.
28. Cooper C., Katona C., Lyketsos K., et al. Asystematic review of treatments for refractory depression in older people. Am J Psychiatry 2011, 168:681-688.
29. Kok R.M., Vink D., Heeren T.J., et al. Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial. JClin Psychiatry 2007, 68:1177-1185.
30. Kok R.M., Heeren T.J., Nolen W.A. Continuing treatment of depression in the elderly: a systematic review and meta-analysis of double-blinded randomized controlled trials with antidepressants. Am J Geriatr Psychiatry 2011, 19:249-255.
31. Alexopoulos G.S., Katz I.R., Reynolds C.F., et al. The expert consensus guideline series. Pharmacotherapy of depressive disorders in older patients. Postgrad Med 2001, 1-86.
32. Bowden C.L. Mood stabilizers. Late-life depression 2004, 211-221. Oxford University Press, New York. S.P. Roose, H.A. Sackeim (Eds.).
33. Sajatovic M., Gildengers A., Al Jurdi R.K., et al. Multisite, open-label, prospective trial of lamotrigine for geriatric bipolar depression: a preliminary report. Bipolar Disord 2011, 13:294-302.
34. Nelson J.C. Stimulants. Late-life depression 2004, 222-231. Oxford University Press, New York. S.P. Roose, H.A. Sackeim (Eds.).
35. Wallace A.E., Kofoed L.L., West A.N. Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients. Am J Psychiatry 1995, 152:929-931.
36. Harrer G., Schmidt U., Kuhn U., et al. Comparison of equivalence between the St.John's Wort extract LoHyp-57 and fluoxetine. Arzneimittelforschung 1999, 49:289-296.
37. Davidson J.R., Crawford C., Ives J.A., et al. Homeopathic treatments in psychiatry: a systematic review of randomized placebo-controlled studies. JClin Psychiatry 2011, 72:795-805.