Homeopathic treatments in psychiatry: A systematic review of randomized placebo-controlled studies

Journal of Clinical Psychiatry

Volumn 72, Issue 6, 2011, Pages 795-805

  Davidson, Jonathan R T ^a   Crawford, Cindy ^b   Ives, John A ^b   Jonas, Wayne B ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b SAMUELI INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; CHRONIC FATIGUE SYNDROME; CLINICAL EFFECTIVENESS; FIBROMYALGIA; HOMEOPATHY; HUMAN; INSOMNIA; JET LAG; MENTAL DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSYCHOSOMATIC DISORDER; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SNORING; STRESS; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANXIETY; HOMEOPATHY; HUMANS; MENTAL DISORDERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SAMPLE SIZE; STRESS, PSYCHOLOGICAL; TREATMENT OUTCOME;

EID: 79959620424     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.10r06580     Document Type: Review

References (62)

1. Freeman MP, Fava M, Lake J, et al. Complementary and alternative medicine in major depressive disorder: the American Psychiatric Association Task Force report. J Clin Psychiatry. 2010;71(6):669-681. doi:10.408/JCP.10cs05959blu PubMed
2. Freeman MP, Mischoulon D, Tedeschini E, et al. Complementary and alternative medicine for major depressive disorder: a meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants. J Clin Psychiatry. 2010;71(6):682-688. doi:10.408/JCP.10r05976blu PubMed
3. Linde K, Clausius N, Ramirez G, et al. Are the clinical effects of homeopathy placebo effects? a meta-analysis of placebo-controlled trials. Lancet. 1997;350(9081):834-843. doi:10.1016/S0140-6736(97)0293-9 PubMed (Pubitemid 27404344)
4. Jonas WB, Kaptchuk TJ, Linde K. A critical overview of homeopathy. Ann Intern Med. 2003;138(5):393-399. PubMed
5. Linde K, Melchart D. Randomized controlled trials of individualized homeopathy: a state-of-the-art review. J Altern Complement Med. 1998;4(4):371-388. doi:10.1089/acm.198.4.371 PubMed (Pubitemid 128542945)
6. Ernst E. Homeopathy: what does the "best" evidence tell us? Med J Aust. 2010;192(8):458-460. PubMed
7. Lewith G. The conundrum of homeopathy: a commentary on Rutten ALB & Stolper CF (2009). J Eval Clin Pract. 2009;15(6):1236-1237. doi:10.1/j.1365- 2753.209.01261.x PubMed
8. Cucherat M, Haugh MC, Gooch M, et al; Homeopathic Medicines Research Advisory Group. Evidence of clinical efficacy of homeopathy: a meta-analysis of clinical trials. Eur J Clin Pharmacol. 2000;56(1):27-33. doi:10.107/s028050716 PubMed (Pubitemid 30317778)
9. Shang A, Huwiler-Müntener K, Nartey L, et al. Are the clinical effects of homoeopathy placebo effects? comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet. 2005;366(9487):726-732. doi:10.1016/S0140-6736(05)6717-2 PubMed (Pubitemid 41207234)
10. Lüdtke R, Rutten ALB. The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. J Clin Epidemiol. 2008;61(12):1197-1204. doi:10.1016/j.jclinepi.208.06.015 PubMed
11. Heirs M, Dean ME. Homeopathy for attention deficit/hyperactivity disorder or hyperkinetic disorder. Cochrane Database Syst Rev. 2007;4:CD005648. doi:10102/14651858.CD05648.pub2.
12. Pilkington K, Kirkwood G, Rampes H, et al. Homeopathy for depression: a systematic review of the research evidence. Homeopathy. 2005;94(3):153-163. doi:10.1016/j.homp.205.04.03 PubMed (Pubitemid 40916915)
13. Pilkington K, Kirkwood G, Rampes H, et al. Homeopathy for anxiety and anxiety disorders: a systematic review of the research. Homeopathy. 2006;95(3):151-162. doi:10.1016/j.homp.206.05.05 PubMed (Pubitemid 44173027)
14. McCarney RW, Warner J, Fisher P, et al. Homeopathy for dementia. Cochrane Database Syst Rev. 2003;1:CD003803. doi:102/14651858.CD03803. 〉
15. Perry R, Terry R, Ernst E. A systematic review of homoeopathy for the treatment of fibromyalgia. Clin Rheumatol. 2010;29(5):457-464. doi:10.107/s1067-09-1361-2 PubMed
16. De Silva V, El-Metwally A, Ernst E, et al; Arthritis Research Campaign Working Group on Complementary and Alternative Medicines. Evidence for the efficacy of complementary and alternative medicines in the management of fibromyalgia: a systematic review. Rheumatology (Oxf). 2010;49(6):1063-1068. doi:10.1093/rheumatology/keq025 PubMed
17. Cooper KL, Relton C. Homeopathy for insomnia: a systematic review of research evidence. Sleep Med Rev. 2010;14(5):329-337. doi:10.1016/j.smrv.209.1. 05 PubMed
18. Jacobs J, Crothers D. Who sees homoeopaths? a study of patients' characteristics in a homeopathic family practice. Br Homeopath J. 1991;80(1):57-58. doi:10.1016/S07-0785(05)80428-4
19. Davidson JRT, Rampes H, Eisen M, et al. Psychiatric disorders in primary care patients receiving complementary medical treatments. Compr Psychiatry. 1998;39(1):16-20. doi:10.1016/S010-40X(98)9027-X PubMed (Pubitemid 28051668)
20. SIGN Network. A Guideline Developer's Handbook. Edinburgh, Scotland: SIGN; 2001. http://www.sign.ac.uk/pdf/sign50.pdf. Accessed March 8, 2011.
21. Jacobs BP, Gundling K. Introduction. In: The ACP Evidence-Based Guide to Complementary and Alternative Medicine. Philadelphia, PA: ACP Press; 2009. http://wdn.ipublishcentral.net/acp/viewinside/25931038387829. Accessed March 7, 2011.
22. Hedges L, Olkin I. Statistical Methods for Meta-Analysis. London, England: Harcourt Brace Jovanovich; 1985.
23. NNT Calculator. Evidence Based Emergency Medicine Web site. http://www.ebem.org/nntcalculator.html. Accessed August 19, 2010.
24. Bonne O, Shemer Y, Gorali Y, et al. A randomized, double-blind, placebocontrolled study of classical homeopathy in generalized anxiety disorder. J Clin Psychiatry. 2003;64(3):282-287. doi:10.408/JCP.v64n0309 PubMed (Pubitemid 36457325)
25. Ngobese JC. The Relative Efficacy of Homeopathic Simillimum Treatment as Compared to Psychological Counseling (Cognitive Therapy and Behavioral Therapy) in the Management of Generalized Anxiety Disorder [minidissertation]. Durban, South Africa: Durban University of Technology; 2006. http://ir.dut.ac.za/handle/ 10321/26. Accessed April 19, 2010.
26. Baker DG, Myers SP, Howden I, et al. The effects of homeopathic Argentum nitricum on test anxiety. Complement Ther Med. 2003;11(2):65-71. doi:10.1016/S0965-29(03)059-1 PubMed
27. McCutcheon LE. Treatment of anxiety with a homeopathic remedy. J Appl Nutr. 1996;48(1&2):2-6. http://homeoinst.org/node/358 (Pubitemid 26320205)
28. Traub G. The Influence of Homeopathic Medicines on Thought Interference, Nervousness and Anxiety in University Students Under Examination Conditions [M. Tech thesis]. Johannesburg, South Africa: Technikon Witwatersrand; March 2000. http://ujdigispace.uj.ac.za:8080/dspace/ handle/10210/2580. Accessed Jun 21, 2010.
29. Vaithilingam H. The Effectiveness of Homoeopathic Simillimum in the Treatment of Job Burnout in the Human Services Field [minidissertation]. Durban, South Africa: Durban University of Technology; 2005. http://ir.dut.ac.za/ bitstream/handle/10321/20/Vaithilingam-2005. pdf?sequence=7. Accessed June 21, 2010.
30. Lipman D, Sexton G, Schlesser J. A randomized double-blind placebo-controlled evaluation of the safety and efficacy of a natural over-the-counter (OTC) medication in the management of snoring. Sleep Breath. 1999;3(2):53-56. doi:10.107/s1325-9-053-0 PubMed
31. Naudé DF, Stephanie Couchman IM, Maharaj A. Chronic primary insomnia: efficacy of homeopathic simillimum. Homeopathy. 2010;99(1):63-68. doi:10.1016/j.homp.209.1.01 PubMed
32. Maharaj A. The Efficacy of Homoeopathic Simillimum in the Treatment of Chronic Primary Insomnia [M. Tech thesis]. Durban, South Africa: Durban Institute of Technology; 2005. http://ir.dut.ac.za/bitstream/ handle/10321/52/Maharaj-2005.pdf?sequence-5. Accessed June 21, 2010.
33. Kumar K. No Jet Lag Scientific Test. www.nojetlag.com/jetlag6.html. Accessed February 9, 2010.
34. La Pine MP, Malcomson FN, Torrance JM, et al. Night shift: can a homeopathic remedy alleviate shift lag? Dimens Crit Care Nurs. 2006;25(3):130-136. doi:10.1097/03465-206050-015 PubMed
35. Kolia-Adam N, Solomon E, Bond J, et al. The efficacy of Coffea cruda on insomnia: a double-blind trial. Simillimum. 2008;21:91-99.
36. Kolia-Adam N. The Efficacy of Coffea cruda 200cH on Insomnia [mini-dissertation]. Johannesburg, South Africa: Technikon Witwatersrand; 2010. http://152.106.6.200:8080/dspace/bitstream/10210/3070/1/Kolia-Adam. pdf. Accessed June 21, 2010.
37. Chapman EH, Angelica J, Spitalny G, et al. Results from a study of the homeopathic treatment of PMS. J Am Inst Homeo. 1994;87:14-21.
38. Yakir M, Kreitler S, Brzezinski A, et al. Effects of homeopathic treatment in women with premenstrual syndrome: a pilot study. Br Homeopath J. 2001;90(3):148-153. doi:10.1054/homp.19.0491 PubMed
39. Laister C-A. The efficacy of homoeopathic simillimum in the treatment of premenstrual syndrome (PMS). http://ir.dut.ac.za/bitstream/ handle/10321/383/ Laister-2008.pdf?sequence=4, accessed June 21, 2010.
40. Kirtland KA. The Efficacy of Folliculinum in the Treatment of Premenstrual Tension [thesis]. Durban, South Africa: Technikon Natal; 1994.
41. Jacobs J, Williams A-L, Girard C, et al. Homeopathy for attention-deficit/ hyperactivity disorder: a pilot randomized-controlled trial. J Altern Complement Med. 2005;11(5):799-806. doi:10.1089/acm.205.1.79 PubMed (Pubitemid 41739353)
42. Frei H, Everts R, von Ammon K, et al. Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial. Eur J Pediatr. 2005;164(12):758-767. doi:10.107/s0431-05-1735-7 PubMed (Pubitemid 41609477)
43. Strauss LC. The efficacy of a homeopathic preparation in the management of attention deficit hyperactivity disorder. Biomed Ther. 2000;18(2):197-201.
44. Cole CL. The Efficacy of Selenium homaccord in the Management of Attention Deficit Hyperactivity Disorder [dissertation]. Johannesburg, South Africa: Technikon Witwatersrand, 1998; 1-73.
45. Chapman EH, Weintraub RJ, Milburn MA, et al. Homeopathic treatment of mild traumatic brain injury: a randomized, double-blind, placebo-controlled clinical trial. J Head Trauma Rehabil. 1999;14(6):521-542. doi:10.1097/019- 19120-02 PubMed (Pubitemid 30027261)
46. Fisher P. An experimental double-blind clinical trial method in homeopathy: use of a limited range of remedies to treat fibrositis. Br Homeopath J. 1986;75(3):142-147. doi:10.1016/S07-0785(86)809-6 (Pubitemid 16030142)
47. Fisher P, Greenwood A, Huskisson EC, et al. Effect of homeopathic treatment on fibrositis (primary fibromyalgia). BMJ. 1989;299(6695):365-366. doi:10.136/bmj.29.695.365 PubMed (Pubitemid 19186693)
48. Awdry R. Homeopathy may help ME. Int J Altern Complement Med. 1996;14:12-16.
49. Weatherley-Jones E, Nicholl JP, Thomas KJ, et al. A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. J Psychosom Res. 2004;56(2):189-197. doi:10.1016/S02-39(03)037-5 PubMed (Pubitemid 38317470)
50. Bell IR, Lewis DA 2nd, Brooks AJ, et al. Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo. Rheumatology (Oxford). 2004;43(5):577-582. doi:10.1093/rheumatology/ keh1 PubMed (Pubitemid 38628186)
51. Saul W. The Effectiveness of Homoeopathic Simillimum Treatment in Chronic Fatigue Syndrome (CFS) [M. Tech thesis]. Durban, Johannesburg, South Africa: Technikon Natal; 2005. http://ir.dut.ac.za/bitstream/ handle/10321/44/Saul-2005. pdf?sequence=16. Accessed June 21, 2010.
52. Colquhoun D. Re-analysis of clinical trial of homoeopathic treatment in fibrositis. Lancet. 1990;336(8712):441-442. doi:10.1016/0140-6736(90)91989-N PubMed (Pubitemid 20252480)
53. Fisher P, Huskisson EC, Turner P, et al. Homoeopathic treatment of fibrositis. Lancet. 1990;336(8720):954. doi:10.1016/0140-6736(90)9234-E PubMed (Pubitemid 20351234)
54. Bell IR, Howerter A, Jackson N, et al. Effects of homeopathic medicines on polysomnographic sleep of young adults with histories of coffee-related insomnia [published online ahead of print July 27, 2010]. Sleep Med. doi:10.1016/j.slep.2010.03.013 PubMed
55. Aaron LA, Buchwald D. A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med. 2001;134(9 Pt 2):868-881. PubMed
56. Häuser W, Bernardy K, Uçeyler N, et al. Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis. JAMA. 2009;301(2):198-209. doi:10.101/jama.208.94 PubMed
57. Häuser W, Bernardy K, Uçeyler N, et al. Treatment of fibromyalgia syndrome with gabapentin and pregabalin - a meta-analysis of randomized controlled trials. Pain. 2009;145(1-2):69-81. doi:10.1016/j.pain.209. 05.014 PubMed
58. Relton C, Smith C, Raw J, et al. Healthcare provided by a homeopath as an adjunct to usual care for fibromyalgia (FMS): results of a pilot randomised controlled trial. Homeopathy. 2009;98(2):77-82. doi:10.1016/j.homp.208.12.04 PubMed
59. Bell IR, Lewis DA 2nd, Schwartz GE, et al. Electroencephalographic cordance patterns distinguish exceptional clinical responders with fibromyalgia to individualized homeopathic medicines. J Altern Complement Med. 2004;10(2):285-299. doi:10.1089/107530432306275 PubMed (Pubitemid 38525734)
60. Bell IR, Lewis DA 2nd, Lewis SE, et al. EEG alpha sensitization in individualized homeopathic treatment of fibromyalgia. Int J Neurosci. 2004;114(9):1195-1220. doi:10.1080/0207450490475724 PubMed (Pubitemid 39213954)
61. Grabia S, Ernst E. Homeopathic aggravations: a systematic review of randomised, placebo-controlled clinical trials. Homeopathy. 2003;92(2):92-98. doi:10.1016/ (Pubitemid 36505178)
62. Grabia S, Ernst E. Homeopathic aggravations: a systematic review of randomised, placebo-controlled clinical trials. Homeopathy. 2003;92(2):92-98. doi:10.1016/S1475-4916(03)07-9 PubMed (Pubitemid 36505178)