Spontaneous Cardiomyopathy in Young Sprague-Dawley Rats:Evaluation of Biological and Environmental Variability

Toxicologic Pathology

Volumn 41, Issue 8, 2013, Pages 1126-1136

  Chanut, Franck ^a   Kimbrough, Carie ^b   Hailey, Rick ^b   Berridge, Brian ^b   Hughes Earle, Angela ^b   Davies, Rhiannon ^a   Roland, Kimberly ^b   Stokes, Alan ^b   Casartelli, Alessandro ^c   York, Malcolm ^a   Jordan, Holly ^b   Crivellente, Federica ^c   Cristofori, Patrizia ^a   Thomas, Heath ^b   Klapwijk, Jan ^a   Adler, Rick ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c Aptuit Inc   (United States)

Author keywords

cardiac troponin I; cardiomyopathy; rat husbandry; safety assessment; Sprague Dawley rats; toxicology studies

Indexed keywords

CARDIAC TROPONIN I; CARDIOMYOPATHY; RAT HUSBANDRY; SAFETY ASSESSMENT.; SPRAGUE-DAWLEY RATS; TOXICOLOGY STUDIES;

ANIMALS; BIOMEDICAL RESEARCH; CARDIOMYOPATHIES; HEART; HISTOCYTOCHEMISTRY; MALE; MYOCARDIUM; NECROSIS; RATS; RATS, SPRAGUE-DAWLEY; RODENT DISEASES; TOXICITY TESTS; TROPONIN I;

TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; HEART LEFT VENTRICLE; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HYPOTHESIS; INFLAMMATORY INFILTRATE; MALE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROGRESSIVE CARDIOMYOPATHY; PROTEIN BLOOD LEVEL; RAT; RISK ASSESSMENT; SPRAGUE DAWLEY RAT;

EID: 84887592652     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623313478692     Document Type: Article

References (21)

1. Aldeman G. A. (2010). Cardiology Essentials in Clinical Practice, p. 158. Springer, London.
2. Berridge B. R. Pettit S. Walker D. B. Jaffe A. S. Schultze A. E. Herman E. Reagan W. J. Lipshultz S. E. Apple F. S. York M. J. (2009). A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am Heart J 158, 21–9.
3. Braundwal E. Antman E. M. Beasley J. W. Califf R. M. Cheitlin M. D. Hochman J. S. Jones R. H. Kereiakes D. Kupersmith J. Levin T. N. Pepine C. J. Schaeffer J. W. Smith E. E. Steward D. E. Theroux P. (2000). ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: Executive summary and recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Unstable Angina). Circulation 102, 1193–209.
4. Burek J. D. (1978). Cardiovascular system. In Pathology of Aging Rats, pp. 75–94. CRC Press, West Palm Beach, FL.
5. Clements P. Brady S. York M. Berridge B. Mikaelian I. Nicklaus R. Gandhi M. Roman I. Stamp C. Davies D. McGill P. Williams T. Pettit S. Walker D., ILSI HESI Cardiac Troponins Working Group Turton J. (2010). Time course characterization of serum cardiac troponins. Heart fatty acid binding protein and morphologic findings with isoproterenol-induced myocardial injury in the Rat. Toxicol Pathol 38, 703–14.
6. Fairweather F. A. (1967). Cardiovascular disease in rats. In Pathology of Laboratory Rats and Mice (Citchin E. Roe F. J. C., eds.), pp. 213–28. Blackwell Scientific, Oxford, Edinburgh, UK.
7. Greaves P. (2011). Cardiovascular system. In Histopathology of Preclinical Toxicity Studies (Greaves P., ed.), pp. 263–324. Elsevier, Amsterdam, The Netherlands.
8. Herman E. Knapton A. Rosen E. Zhang J. Estis J. Agee S. J. Lu Q. A. Todd J. A. Lipshultz S. E. (2011). Baseline serum cardiac troponin I concentrations in Sprague-Dawley, spontaneous hypertensive, wistar, wistar-kyoto, and Fisher rats as determined with an ultrasensitive immunoassay. Toxicol Pathol 39, 653–63.
9. Jokinen M. P. Lieuallen W. G. Boyle M. C. Johnson C. L. Malarkey D. E. Nyska A. (2011). Morphologic aspects of rodent cardiotoxicity in a retrospective evaluation of national toxicology program studies. Toxicol Pathol 39, 850–60.
10. Jokinen M. P. Lieuallen W. G. Johnson C. L. Dunnick J. Nyska A. (2005). Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems. The National Toxicology Program experience. Cardiovasc Toxicol 5, 227–44.
11. Keenan M. K. Hughes-Earle A. R. Maleeff B. E. Thomas H. C. Adler R. R. Cristofori P. G. Klapwijk J. C. (2010). Industry survey of approaches to examination and terminology of spontaneous changes in the Heart of Young Rats. Toxicol Pathol 38, 995–98.
12. Kemi M. Keenan K. P. Mccoy C. Hoe C. Soper K. A. Ballam G. C. Van Zwieten M. J. (2000). The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats. Toxicol Pathol 28, 285–96.
13. O’Brien P. J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245, 206–18.
14. P.J., O'Brien, D.D.C., Smith, T.J., Knechtel, M.A., Marchak, I., Pruimboom-Brees, D.J., Brees, D.P., Spratt, F.J., Archer, P., Butler, A.N., Potter, J.P., Provost, J., Richard, P.A., Snyder, W.J., Reagan, Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals, Lab Anim, (2006), 40, 153-171
15. Ruben Z. Arceo R. J. Bishop S. P. Elwell M. R. Kerns W. D. Mesfin G. M. Sandusky G. E. Van Vleet J. F. (2000). Non-proliferative lesions of the heart and vasculature in rats. In Guides for Toxicologic Pathology, pp. 1–10. STP/ARP/AFIP, Washington, DC.
16. Schultze A. E. Carpenter K. H. Wians F. H. Agee S. J. Minyard J. Lu Q. A. Todd J. Konrad R. J. (2009). Longitudinal studies of cardiac troponin-I concentrations in serum from male sprague dawley rats: Baseline reference ranges and effects of handling and placebo dosing on biological variability. Toxicol Pathol 37, 754–60.
17. A.E., Schultze, B.W., Main, D.G., Hall, W.P., Hoffman, H.-Y.C., Lee, B.L., Ackermann, M.L., Pritt, H.W., Smith, A comparison of mortality and cardiac biomarker response between three outbred stocks of Sprague Dawley rats treated with isoproterenol, Toxicol Pathol, (2011), 39
18. Walker D. B. (2006). Serum chemical biomarkers of cardiac injury for nonclinical safety testing. Toxicol Pathol 34, 94–104.
19. Wallace K. B. Hausner E. Herman E. Holt G. D. Macgregor J. T. Metz A. L. Murphy E. Rosenblum I. Y. Sistare F. D. York M. J. (2004). Serum troponins as biomarkers of drug-induced cardiac toxicity. Toxicol Pathol 32, 106–21.
20. Yamori Y. Okomoto K. (1976). Japanese spontaneously hypertensive rat (SHR). Clin Exp Pharmacol Physiol Suppl 3, 1–4.
21. York M. Scudamore C. Brady S. Chen C. Wilson S. Curtis M. Evans G. Griffiths W. Whayman M. Williams T. Turton J. (2007). Characterization of troponin responses in isoproterenol-induced cardiac injury in the hanover Wistar Rat. Toxicol Pathol 35, 606–17.