Longitudinal studies of cardiac troponin-I concentrations in Serum from male sprague dawley rats: baseline reference ranges and effects of handling and placebo dosing on biological variability

Toxicologic Pathology

Volumn 37, Issue 6, 2009, Pages 754-760

  Schultze, A Eric ^a   Carpente, Kent H ^a   Wians, Frank H ^b   Agee, Sara J ^c   Minyard, Jennifer ^c   Lu, Quynh Anh ^c   Todd, John ^c   Konrad, Robert J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c SINGULEX INC   (United States)

Author keywords

Cardiac troponin concentration; Cardiotoxicity; CTnI; Rat; Rat husbandry; Reference ranges; Toxicology studies

Indexed keywords

PLACEBO; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CARDIOTOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE MARKER; DOG; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; HUMAN; IMMUNOASSAY; LONGITUDINAL STUDY; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; LONGITUDINAL STUDIES; MALE; MYOCARDIUM; PLACEBOS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SODIUM CHLORIDE; STATISTICS, NONPARAMETRIC; TOXICITY TESTS; TROPONIN I;

ANIMALIA; CANIS FAMILIARIS; RATTUS; RATTUS NORVEGICUS;

EID: 70749108457     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309343777     Document Type: Article

References (18)

1. Adamcová, M., Simůnek, T., Kaiserová, H., Popelová, O., Sterba, M., Potá-cová, A., Vávrová, J., Maláková, J., and Gersl, V. (2007). In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity. Toxicology 237, 218-28.
2. Antman, E., Bassand, J. P., Klein, W., Ohman, M., Sendon, J. L. L., Rydén, L., Simoons, M., and Tendera, M. (2000). Myocardial infarction redefined-a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction: The Joint European Society of Cardiology/American College of Cardiology Committee. J Am Coll Cardiol 36, 959-69.
3. Apple, F. S., Murakami, M. M., Ler, R., Walker, D., and York, M., for the HESI Technical Committee of Biomarkers Working Group on Cardiac Troponins (2008). Analytical characteristics of commercial cardiac troponin I and T immunoassays in serum from rats, dogs, and monkeys with induced acute myocardial injury. Clin Chem 54, 1982-89.
4. Berridge, B. R., Pettit, S., Walker, D. B., Jaffe, A. S., Schultze, A. E., Herman, E., Reagan, W. J., Lipshultz, S. E., Apple, F. S., and York, M. J. (2009). A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am Heart J 158, 21-29.
5. Bundgaard, C., Jørgensen, M., and Mørk, A. (2007). An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents. J Pharmacol Toxicol Methods 55, 214-23.
6. Fokkema, M. R., Herrmann, Z., J, F. A., and Moecks, J. (2006). Reference change values for brain natriuretic peptides revisited. Clin Chem 52, 1602-3.
7. Mitra, M. S., Donthamsetty, S., White, B., and Mehendale, H. M. (2008). High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity. Toxicol Appl Pharmacol 231, 413-22.
8. NACB Writing Group, Wu, A. H. B., Jaffe, A. S., Apple, F. S., Jesse, R. L., Francis, G. L., Morrow, D. A., Newby, L. K., Ravkilde, J., Tang, W. H., Christenson, R. H.; NACB Ccommittee, Cannon, C. P., and Storrow, A. B. (2007). National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin Chem 53:2086-96.
9. Nolan, T. E., Loughnane, M., and Jacobson, A. (2008). Tethered infusion and withdrawal in lab animals. ALN Magazine July/August.
10. O'Brien P. J. (2006). Blood cardiac troponin in toxic myocardial injury: archetype of a translational safety biomarker. Expert Rev Mol Diagn 6, 685-702.
11. O'Brien, P. J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245, 206-18.
12. O'Brien, P. J., Smith, D. E., Knechtel, T. J., Marchak, M. A., Pruimboom-Brees, I., Brees, D. J., Spratt, D. P., Archer, F. J., Butler, P., Potter, A. N., Provost, J. P., Richard, J., Snyder, P. A., and Reagan, W. J. (2006). Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Lab Anim 40, 153-71.
13. Schultze, A. E., Konrad, R. J., Credille, K. M., Lu, Q. A., and Todd, J. (2008). Ultrasensitive cross-species measurement of cardiac troponin-I using the Erenna immunoassay system. Toxicol Pathol 36, 777-82.
14. Thygesen, K., Alpert, J. S., White, H. D., et al. and the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. (2007). Universal definition of myocardial infarction. Circulation 116, 2634-53.
15. Todd, J., Freese, B., Lu, A., Held, D., Morey, J., Livingston, R., and Goix, P. (2007). Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem 53, 1990-95.
16. Wu, A. H., Fukushima, N., Puskas, R., Todd, J., and Goix, P. (2006). Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector. Clin Chem 52, 2157-59.
17. Wu, A. H., Lu, Q. A., Todd, J., Moecks, J., and Wians, F. (2009). Short-and long-term biological variation in cardiac troponin I with a highsensitivity assay: Implications for clinical practice. Clin Chem 55, 52-58.
18. York, M., Scudamore, C., Brady, S., Chen, C., Wilson, S., Curtis, M., Evans, G., Griffiths, W., Whayman, M., Williams, T., and Turton, J. (2007). Characterization of troponin responses in isoproterenol-induced cardiac injury in the Hanover Wistar rat. Toxicol Pathol 35, 606-17.