Cell-cycle arrest at G2/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines

Neoplasma

Volumn 60, Issue 6, 2013, Pages 620-626

  Cheng, X ^a   Zhou, D ^a   Wei, J ^a   Lin, J ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Anti proliferative; Cell cycle; Colorectal cancer (CRC); G2 M phase; Mitofusin 2(Mfn2)

Indexed keywords

CASPASE 3; CYCLIN B1; MITOFUSIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; MFN2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN;

ADENOVIRUS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DENSITOMETRY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MITOFUSIN 2 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; CELL CYCLE G2 PHASE; CELL DIVISION; COLON; COLORECTAL TUMOR; COMPARATIVE STUDY; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RECTUM; TUMOR CELL CULTURE;

ADENOVIRIDAE; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL PROLIFERATION; COLON; COLORECTAL NEOPLASMS; FLOW CYTOMETRY; G2 PHASE; GTP PHOSPHOHYDROLASES; HUMANS; MITOCHONDRIAL PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECTUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84887522102     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2013_080     Document Type: Article

References (24)

1. LEVIN AA. Patient safety: rejecting the status quo. N C Med J 2005; 66: 91-95.
2. JENKINSON F, STEELE RJ. Colorectal cancer screening-methodology. Surgeon 2010; 8: 164-171. http://dx.doi.org/10.1016/j.surge.2009.10.015
3. SAIF MW, CHU E. Biolog y of colorectal cancer. Cancer J 2010; 16: 196-201. http://dx.doi.org/10.1097/PPO.0b013e3181e076af
4. SHAW P, COSTA J. Molecular biology of colon cancer (review). Anticancer Res 1989; 9: 21-27.
5. CHEN KH, GUO X, MA D, GUO Y, LI Q, et al. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol 2004; 6: 872-883. http://dx.doi.org/10.1038/ncb1161
6. KARBOWSKI M, NORRIS KL, CLELAND MM, JEONG SY, YOULE RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006; 443: 658-662. http://dx.doi.org/10.1038/nature05111
7. KARBOWSKI M, LEE YJ, GAUME B, JEONG SY, FRANK S, et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol 2002; 159: 931-938. http://dx.doi.org/10.1083/jcb.200209124
8. WU L, LI Z, ZHANG Y, ZHANG P, ZHU X, et al. Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells. Mol Cancer Ther 2008; 7: 222-232. http://dx.doi.org/10.1158/1535-7163.MCT-07-0382
9. WANG W, CHENG X, LU J, WEI J, FU G, et al. Mitofusin-2 is a novel direct target of p53. Biochem Biophys Res Commun 2010; 400: 587-592. http://dx.doi.org/10.1016/j.bbrc.2010.08.108
10. WANG W, ZHU F, WANG S, WEI J, JIA C, et al. HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncol Rep 2010; 24: 183-188.
11. JEMAL A, MURRAY T, WARD E, SAMUELS A, TIWARI RC, et al. Cancer statistics, 2005. CA Cancer J Clin 2005; 55: 10-30. http://dx.doi.org/10.3322/canjclin.55.1.10
12. WHITE RL. Colon cancer. Molecular biology of the APC protein. Pathol Biol (Paris) 1997; 45: 240-244.
13. BACH D, PICH S, SORIANO FX, VEGA N, BAUMGARTNER B, et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem 2003; 278: 17190-17197. http://dx.doi.org/10.1074/jbc.M212754200
14. BAGCHI A, MILLS AA. The quest for the 1p36 tumor suppressor. Cancer Res 2008; 68: 2551-2556. http://dx.doi.org/10.1158/0008-5472.CAN-07-2095
15. MORI N, MOROSETTI R, SPIRA S, LEE S, BEN-YEHUDA D, et al. Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia. Blood 1998; 92: 3405-3409.
16. SMEDLEY D, SIDHAR S, BIRDSALL S, BENNETT D, HERLYN M, et al. Characterization of chromosome 1 abnormalities in malignant melanomas. Genes Chromosomes Cancer 2000; 28: 121-125. http://dx.doi.org/10.1002/(SICI)1098-2264(200005)28:1<121::AID-GCC14>3.0.CO;2-O
17. CHEN H, DETMER SA, EWALD AJ, GRIFFIN EE, FRASER SE, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003; 160: 189-200. http://dx.doi.org/10.1083/jcb.200211046
18. GUO X, CHEN KH, GUO Y, LIAO H, TANG J, et al. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res 2007; 101: 1113-1122. http://dx.doi.org/10.1161/CIRCRESAHA.107.157644
19. SHERR CJ. Cancer cell cycles. Science 1996; 274: 1672-1677. http://dx.doi.org/10.1126/science.274.5293.1672
20. MURRAY AW. Recycling the cell cycle: cyclins revisited. Cell 2004; 116: 221-234. http://dx.doi.org/10.1016/S0092-8674(03)01080-8
21. BUCHER N, BRITTEN CD. G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer 2008; 98: 523-528. http://dx.doi.org/10.1038/sj.bjc.6604208
22. STARK GR, TAYLOR WR. Analyzing the G2/M checkpoint. Methods Mol Biol 2004; 280: 51-82.
23. TAMEMOTO H, KADOWAKI T, TOBE K, UEKI K, IZUMI T, et al. Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. J Biol Chem 1992; 267: 20293-20297.
24. CHAMBARD JC, LEFLOCH R, POUYSSEGUR J, LENORMAND P. ERK implication in cell cycle regulation. Bba-Mol Cell Res 2007; 1773: 1299-1310.