Antiplasmodial, HIV-1 reverse transcriptase inhibitory and cytotoxicity properties of Centratherum punctatum Cass. and its fractions

South African Journal of Botany

Volumn 90, Issue , 2014, Pages 17-19

  Chukwujekwu, J C ^a   Ndhlala, A R ^a   de Kock, C A ^b   Smith, P J ^b   Van Staden, J ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Anti HIV; Antiplasmodial activity; Asteraceae; Centratherum punctatum; Cytotoxicity

Indexed keywords

ENZYME ACTIVITY; ETHANOL; FRACTIONATION; HERB; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION; INHIBITOR; METHANE; PLANT EXTRACT; TOXICITY;

EID: 84887507300     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2013.10.001     Document Type: Article

References (22)

1. Almeida V.L., Oliveira A.B., Chiari E., Boaventura M.A.D. Constituents of Hololepis pedunculata leaves and their trypanocidal activity. Chemistry of Natural Compounds 2006, 42:734-735.
2. Amaya S., Pereira J.A., Borkosky S.A., Valdez J.C., Bardón A., Arena M.E. Inhibition of quorum sensing in Pseudomonas aeruginosa by sesquiterpene Lactones. Phytomedicine 2012, 19:1173-1177.
3. Basco L.K., Mitaku S., Skaltsounis A.L., Ravelomanaintsoa N., Tillequin F., Koch M., Le Bras J. In vitro activities of acridone alkaloids against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 1994, 5:1169-1171.
4. Bevelle C.A., Handy G.A., Segal R.A., Cordell G.A., Farnsworth N.R. Isocentratherin, a cytotoxic germacranolide from Centratherum punctatum (Compositae). Phytochemistry 1981, 20:1605-1607.
5. Bessong P.O., Obi C.L., Andréola M.L., Rojas L.B., Pouysegu L., Igumbor E., Meyer J.J.M., Quideau S., Litvak S. Evaluation of selected South African medicinal plants for inhibitory properties against human immunodeficiency virus type 1 reverse transcriptase and integrase. Journal of Ethnopharmacology 2005, 99:83-91.
6. Burim R.V., Canalle R., Lopes J.L.C., Vichnewski W., Takahashi C.S. Genotoxic action of the sesquiterpene lactone centratherin on mammalian cells in vitro and in vivo. Teratogenesis, Carcinogenesis, and Mutagenesis 2001, 21:383-393.
7. Chukwujekwu J.C., Amoo S.O., Van Staden J. Antimicrobial, antioxidant, mutagenic and antimutagenic activities of Distephanus angulifolius and Ormocarpum trichocarpum. Journal of Ethnopharmacology 2013, 148:975-979.
8. Costa Bieski I.G., Santos F.R., de Oliveira R.M., Espinosa M.M., Macedo M., Albuquerque U.P., de Oliveira Martins D.T. Ethnopharmacology of medicinal plants of the Pantanal Region (Mato Grosso, Brazil). Evidence-Based Complementary and Alternative Medicine 2012, 2012. (Article ID 272749).
9. Copeland R.A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists 2005, Wiley-Intescience, New Jersey.
10. Gbolade A.A., Dzamic A.M., Ristic M.S., Marin P.D. Essential oil composition of Centratherum punctatum from Nigeria. Chemistry of Natural Compounds 2009, 45:118-119.
11. Lobo J.F.R., Castro E.S., Gouvea D.R., Fernandes C.P., de Almeida F.B., de Amorim L.M.F., Burth P., Rocha L., Santos M.G., Harmerski L., Lopes N.P., Pinto A.C. Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines. Brazilian Journal of Pharmacognosy 2012, 22:1295-1300.
12. Makler M.T., Ries J.M., Williams J.A., Bancroft J.E., Piper R.C., Gibbins B.L., Hinrichs D.J. Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. The American Society of Tropical Medicine and Hygiene 1993, 48:739-741.
13. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
14. Ndhlala A.R., Finnie J.F., Van Staden J. In vitro antioxidant properties, HIV-1 reverse transcriptase and acetylcholinesterase inhibitory effects of traditional herbal preparations sold in South Africa. Molecules 2010, 15:6888-6904.
15. Ohno N., McCormick S., Mabry T.J. Centratherin, a new germacranolide from Centratherum punctatum. Phytochemistry 1979, 18:681-682.
16. Pawar N.K., Arumugam N. Leaf extract of Centratherum punctatum exhibits antimicrobial, antioxidant and anti-proliferative properties. Asian Journal of Pharmaceutical and Clinical Research 2011, 4:71-76.
17. Rubinstein L.V., Shoemaker R.H., Paull K.D., Simon R.M., Tosini S., Skehan P., Scudiero D.A., Monks A., Boyd M.R. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay against a diverse panel of human tumor cell lines. Journal of the National Cancer Institute 1990, 82:1113-1118.
18. Sakamoto H.T., Gobbo-Neto L., Cavalheiro A.J., Lopes N.P., Lopes J.L.C. Quantitative HPLC analysis of sesquiterpene lactones and determination of chemotypes in Eremanthus seidelii MacLeish & Schumacher (Asteraceae). Journal of the Brazilian Chemical Society 2005, 16:1396-1401.
19. Spallarossa A., Cesarini S., Ranise A., Bruno O., Schenone S., Colla P.L., Collu G., Sanna G., Secci B., Loddo R. Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 2009, 44:1650-1663.
20. Trager W., Jensen J.B. Human malaria parasite in continuous culture. Science 1976, 193:673-675.
21. Vongvanich N., Kittakopp P., Charoenchai P., Intamas P., Sriklung K., Thebtaranonth Y. Antiplasmodial, antimycobacterial and cytotoxic principles from Camchaya calcarea. Planta Medica 2006, 72:1427-1430.
22. WHO World Malaria Report 2011 (21/05/2013). http://www.who.in0074.