Evaluation of a Liquid Dispenser for Assay Development and Enzymology in 1536-Well Format

Journal of Laboratory Automation

Volumn 18, Issue 3, 2013, Pages 245-250

  Butendeich, Heike ^a   Pierret, Noëlle M ^a   Numao, Shin ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

assay development; biochemical assay; enzyme kinetics; high throughput screen; lab automation; liquid dispenser

Indexed keywords

ASSAY DEVELOPMENT; BIOCHEMICAL ASSAY; BIOCHEMICAL EXPERIMENTS; CONCENTRATION GRADIENTS; HIGH-THROUGHPUT SCREENING; HIGH-THROUGHPUT SCREENS; LAB AUTOMATION; MULTIPLE COMPONENTS;

ENZYME KINETICS; EXPERIMENTS; FLUIDICS; LIQUIDS;

DISPENSERS;

ARTICLE; BIOCHEMISTRY; CONCENTRATION (PARAMETERS); CONTROL SYSTEM; DENSITY GRADIENT; ENZYME ACTIVITY; ENZYME KINETICS; ENZYMOLOGY; EQUIPMENT DESIGN; FLUORESCENCE; HIGH THROUGHPUT SCREENING; LABORATORY AUTOMATION; LABORATORY DEVICE; LIQUID DISPENSER; MICROTITER PLATE ASSAY; PROCESS DEVELOPMENT; SYSTEM ANALYSIS;

ASSAY DEVELOPMENT; BIOCHEMICAL ASSAY; ENZYME KINETICS; HIGH-THROUGHPUT SCREEN; LAB AUTOMATION; LIQUID DISPENSER;

ENZYMES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 84887499962     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068212472184     Document Type: Article

References (8)

1. Macarron R.,Banks M. N.,Bojanic D.,Burns D. J.,Cirovic D. A.,Garyantes T.,Green D. V.,Hertzberg R. P.,Janzen W. P.,Paslay J. W.,Schopfer U.,Sittampalam G. S.Impact of High-Throughput Screening in Biomedical Research.Nat. Rev. Drug Discov. 2011;10:188-195.
2. Mageean C. J.,Büttner F. H.Miniaturisation of a High Throughput Screening Assay Comparing Air Displacement and Capillary-Based Nanolitre Transfer Technologies.Comb. Chem. High Throughput Screen. 2010;13:229-241.
3. Boston, MA: PerkinElmer; 2003:.
4. Mayr L. M.,Bojanic D.Novel Trends in High-Throughput Screening.Curr. Opin. Pharmacol. 2009;9:580-588.
5. Zhang J.,Chung T.,Oldenbourg K.A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.J. Biomol. Screen. 1999;4:67-73.
6. Leytus S. P.,Patterson W. L.,Mangel W. F.New Class of Sensitive and Selective Substrates for Serine Proteinases: Amino Acid and Dipeptide Derivatives of Rhodamine.Biochem. J. 1983;215:253-260.
7. Lebakken C. S.,Riddle S. M.,Singh U.,Frazee J.,Eliason H. C.,Gao Y.,Reichling L. J.,Marks B. D.,Vogel K. W.Development and Applications of a Broad-Coverage, TR-FRET-Based Kinase Binding Assay Platform.J. Biomol. Screen. 2009;14:924-935.
8. Niles W. D.,Coassin P. J.Piezo- and Solenoid Valve-Based Liquid Dispensing for Miniaturized Assays.Assay Drug Dev. Technol. 2005;3:189-202.