Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: A reappraisal

The Scientific World Journal

Volumn 2013, Issue , 2013, Pages

  Nardone, Raffaele ^a,b   Höller, Yvonne ^a   Storti, Monica ^b   Christova, Monica ^c   Tezzon, Frediano ^b   Golaszewski, Stefan ^a   Trinka, Eugen ^a   Brigo, Francesco ^b,d  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b FRANZ TAPPEINER HOSPITAL   (Italy)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; GLUTAMIC ACID; ACETYLCHOLINESTERASE; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC RECEPTOR;

ALCOHOL ABSTINENCE; BASAL AMYGDALA; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; CONFABULATION; EXCITOTOXICITY; EXECUTIVE FUNCTION; EXPERIMENTAL MODEL; FOREBRAIN; HIPPOCAMPUS; HUMAN; KNOWLEDGE; LONG TERM MEMORY; MALNUTRITION; MEMORY DISORDER; NEUROANATOMY; NEUROPSYCHOLOGY; NONHUMAN; REVIEW; RODENT MODEL; SPATIAL MEMORY; THIAMINE DEFICIENCY; WORKING MEMORY; ANIMAL; BIOSYNTHESIS; DIENCEPHALON; DOWN REGULATION; KORSAKOFF PSYCHOSIS; METABOLISM; PATHOLOGY; WERNICKE ENCEPHALOPATHY;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINE O-ACETYLTRANSFERASE; DIENCEPHALON; DOWN-REGULATION; HIPPOCAMPUS; HUMANS; KORSAKOFF SYNDROME; RECEPTORS, CHOLINERGIC; THIAMINE DEFICIENCY; WERNICKE ENCEPHALOPATHY;

EID: 84887499952     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2013/309143     Document Type: Review

References (95)

1. Kopelman M. D., Thomson A. D., Guerrini I., Marshall E. J., The korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol and Alcoholism 2009 44 2 148 154 2-s2.0-61449257436 10.1093/alcalc/agn118
2. Victor M., Adams R. D., Collins G. H., Wernicke-Korsakoff Syndrome and Related Neurologic Disorders due to Alcoholism and Malnutrition 1989 Philadelphia, Pa, USA FA Davies Company
3. Vetreno R. P., Anzalone S. J., Savage L. M., Impaired, spared, and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands. Neurobiology of Learning and Memory 2008 90 1 237 244 2-s2.0-44649114535 10.1016/j.nlm.2008.04.001
4. Harper C. G., Kril J. J., Neuropathology of alcoholism. Alcohol and Alcoholism 1990 25 2-3 207 216 2-s2.0-0025364553 (Pubitemid 20215751)
5. Parsons O. A., Nixon S. J., Neurobehavioral sequelae of alcoholism. Neurologic Clinics 1993 11 1 205 218 2-s2.0-0027417175 (Pubitemid 23063096)
6. Harper C. G., Giles M., Finlay-Jones R., Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. Journal of Neurology Neurosurgery and Psychiatry 1986 49 4 341 345 2-s2.0-0022639125 (Pubitemid 16116131)
7. Harper C., The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? Journal of Neuropathology and Experimental Neurology 1998 57 2 101 110 2-s2.0-0031881598 (Pubitemid 28084272)
8. Torvik A., Lindboe C. F., Rogde S., Brain lesions in alcoholics: a neuropathological study with clinical correlations. Journal of the Neurological Sciences 1982 56 2-3 233 248 2-s2.0-0019903774 (Pubitemid 12002346)
9. Alexander-Kaufman K., Harper C., Wilce P., Matsumoto I., Cerebellar vermis proteome of chronic alcoholic individuals. Alcoholism 2007 31 8 1286 1296 2-s2.0-34447330194 10.1111/j.1530-0277.2007.00437.x (Pubitemid 47063130)
10. Joyce E. M., Aetiology of alcoholic brain damage: alcoholic neurotoxicity or thiamine malnutrition? British Medical Bulletin 1994 50 1 99 114 2-s2.0-0028297454 (Pubitemid 24097034)
11. Bowden S. C., Separating cognitive impairment in neurologically asymptomatic alcoholism from wernicke-korsakoff syndrome: is the neuropsychological distinction justified? Psychological Bulletin 1990 107 3 355 366 2-s2.0-0025428222
12. Lishman W. A., Alcoholic dementia: a hypothesis. The Lancet 1986 1 8491 1184 1186 2-s2.0-0022608006 (Pubitemid 16122425)
13. Lishman W. A., Alcohol and the brain. British Journal of Psychiatry 1990 156 635 644 2-s2.0-0025250247 (Pubitemid 20147547)
14. Smith D. M., Atkinson R. M., Alcoholism and dementia. International Journal of the Addictions 1995 30 13-14 1843 1869 2-s2.0-0028875185
15. Oscar-Berman M., Kirkley S. M., Gansler D. A., Couture A., Comparisons of Korsakoff and Non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. Alcoholism 2004 28 4 667 675 2-s2.0-1942454455 10.1097/01.ALC.0000122761.09179.B9 (Pubitemid 38506903)
16. Kopelman M. D., Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients. Neuropsychologia 1989 27 4 437 460 2-s2.0-0024601430 (Pubitemid 19109616)
17. Butters N., Granholm E., Salmon D. P., Grant I., Wolfe J., Episodic and semantic memory: a comparison of amnesic and demented patients. Journal of Clinical and Experimental Neuropsychology 1987 9 5 479 497 2-s2.0-0023424981
18. Dirksen C. L., Howard J. A., Cronin-Golomb A., Oscar-Berman M., Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff's syndrome, patients with Parkinson's disease, and patients with rupture and repair of the anterior communicating artery. Neuropsychiatric Disease and Treatment 2006 2 3 327 339 2-s2.0-33750033692 10.2147/nedt.2006.2.3.327 (Pubitemid 44566708)
19. Gansler D. A., Harris G. J., Oscar-Berman M., Streeter C., Lewis R. F., Ahmed I., Achong D., Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: a pilot SPECT study. Journal of Studies on Alcohol 2000 61 1 32 37 2-s2.0-0033987179 (Pubitemid 30005056)
20. Fama R., Pfefferbaum A., Sullivan E. V., Visuoperceptual learning in alcoholic Korsakoff syndrome. Alcoholism 2006 30 4 680 687 2-s2.0-33645349571 10.1111/j.1530-0277.2006.00085.x
21. McGlinchey-Berroth R., Cermak L. S., Carrillo M. C., Armfield S., Gabrieli J. D. E., Disterhoft J. F., Impaired delay eyeblink conditioning in amnesic Korsakoff's patients and recovered alcoholics. Alcoholism 1995 19 5 1127 1132 2-s2.0-0028801236 10.1111/j.1530-0277.1995.tb01590.x
22. Butters N., Cermak L. S., Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia 1980 New York, NY, USA Academic Press
23. Meudell P. A., Mayes A. R., Neary D., Oborne D. J., Gruneberg M. M., Eiser J. R., Is amnesia caused by a consolidation impairment? Research in Psychology and Medicine 1979 1 London, UK Academic Press 323 330
24. Moscovitch M., Cermak L. S., Multiple dissociations of function in amnesia. Human Memory and Amnesia 1982 Hillsdale, NJ, USA Lawrence Erlbaum 337 370
25. Baddeley A. D., Warrington E. K., Amnesia and the distinction between long- and short-term memory. Journal of Verbal Learning and Verbal Behavior 1970 9 2 176 189 2-s2.0-0001644260
26. Huppert F. A., Piercy M., The role of trace strength in recency and frequency judgements by amnesic and control subjects. The Quarterly Journal of Experimental Psychology 1978 30 2 347 354 2-s2.0-0017965807
27. Postma A., Van Asselen M., Keuper O., Wester A. J., Kessels R. P. C., Spatial and temporal order memory in Korsakoff patients. Journal of the International Neuropsychological Society 2006 12 3 327 336 2-s2.0-33745643782 10.1017/S1355617706060449 (Pubitemid 43970898)
28. Warrington E. K., Weiskrantz L., Amnesic syndrome: consolidation or retrieval? Nature 1970 228 5272 628 630 2-s2.0-0014945681 10.1038/228628a0
29. Gilboa A., Alain C., Stuss D. T., Melo B., Miller S., Moscovitch M., Mechanisms of spontaneous confabulations: a strategic retrieval account. Brain 2006 129 6 1399 1414 2-s2.0-33745063666 10.1093/brain/awl093 (Pubitemid 43999373)
30. Schnider A., Spontaneous confabulation and the adaptation of thought to ongoing reality. Nature Reviews Neuroscience 2003 4 8 662 671 2-s2.0-0142104951 10.1038/nrn1179 (Pubitemid 37280161)
31. Fotopoulou A., Conway M. A., Solms M., Confabulation: motivated reality monitoring. Neuropsychologia 2007 45 10 2180 2190 2-s2.0-34247562742 10.1016/j.neuropsychologia.2007.03.003 (Pubitemid 46678111)
32. Schliebs R., Arendt T., The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. Journal of Neural Transmission 2006 113 11 1625 1644 2-s2.0-33750445930 10.1007/s00702-006-0579-2 (Pubitemid 44657659)
33. Savage L. M., Roland J., Klintsova A., Selective septohippocampal: but not forebrain amygdalar: cholinergic dysfunction in diencephalic amnesia. Brain Research 2007 1139 1 210 219 2-s2.0-33847295123 10.1016/j.brainres.2006.12.083
34. McKinney M., Jacksonville M.C., Brain cholinergic vulnerability: relevance to behavior and disease. Biochemical Pharmacology 2005 70 8 1115 1124 2-s2.0-24944524929 10.1016/j.bcp.2005.05.019 (Pubitemid 41317506)
35. Wainer B. H., Levey A. I., Rye D. B., Mesulam M. M., Mufson E. J., Cholinergic and non-cholinergic septohippocampal pathways. Neuroscience Letters 1985 54 1 45 52 2-s2.0-0021944259 (Pubitemid 15126757)
36. Arendt T., Bruckner M. K., Bigl V., Marcova L., Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease. Journal of Comparative Neurology 1995 351 2 189 222 2-s2.0-0028945009 10.1002/cne.903510203
37. Cullen K. M., Halliday G. M., Caine D., Kril J. J., The nucleus basalis (Ch4) in the alcoholic Wernicke-Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients. Journal of Neurology Neurosurgery and Psychiatry 1997 63 3 315 320 2-s2.0-0030850997 (Pubitemid 27412372)
38. De Rosa E., Hasselmo M. E., Muscarinic cholinergic neuromodulation reduces proactive interference between stored odor memories during associative learning in rats. Behavioral Neuroscience 2000 114 1 32 41 2-s2.0-0034059980 10.1037//0735-7044.114.1.32 (Pubitemid 30131584)
39. Boegman R. J., Jhamandas K., Cockhill J., Differential effect of excitotoxins in the basal forebrain on choline acetyltransferase activity in the cortex and amygdala. Annals of the New York Academy of Sciences 1992 648 254 255 2-s2.0-0026674516
40. Wenk G. L., Willard L. B., The neural mechanisms underlying cholinergic cell death within the basal forebrain. International Journal of Developmental Neuroscience 1998 16 7-8 729 735 2-s2.0-0032463256 10.1016/S0736-5748(98)00081-1 (Pubitemid 29151761)
41. Hartikka J., Hefti F., Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes. Journal of Neuroscience 1988 8 8 2967 2985 2-s2.0-0023787394
42. Lauterborn J. C., Tran T. M. D., Isackson P. J., Gall C. M., Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus. NeuroReport 1993 5 3 273 276 2-s2.0-0027769873 (Pubitemid 24026252)
43. Acsády L., Pascual M., Rocamora N., Soriano E., Freund T. F., Nerve growth factor but not neurotrophin-3 is synthesized by hippocampal GABAergic neurons that project to the medial septum. Neuroscience 2000 98 1 23 31 2-s2.0-0342657274 10.1016/S0306-4522(00)00091-9 (Pubitemid 30349140)
44. Berger-Sweeney J., Heckers S., Mesulam M.-M., Wiley R. G., Lappi D. A., Sharma M., Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. Journal of Neuroscience 1994 14 7 4507 4519 2-s2.0-0028301626 (Pubitemid 24200569)
45. Heckers S., Ohtake T., Wiley R. G., Lappi D. A., Geula C., Mesulam M.-M., Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor. Journal of Neuroscience 1994 14 3 I 1271 1289 2-s2.0-0028346917 (Pubitemid 24081922)
46. Woolf N. J., Jacobs R. W., Butcher L. L., The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease. Neuroscience Letters 1989 96 3 277 282 2-s2.0-0024576043 (Pubitemid 19026693)
47. Wang Y.-Q., Bian G.-L., Bai Y., Cao R., Chen L.-W., Identification and kainic acid-induced up-regulation of low-affinity p75 neurotrophin receptor (p75NTR) in the nigral dopamine neurons of adult rats. Neurochemistry International 2008 53 3-4 56 62 2-s2.0-48349086088 10.1016/j.neuint.2008.06.007
48. Zhao N., Zhong C., Wang Y., Zhao Y., Gong N., Zhou G., Xu T., Hong Z., Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage. Neurobiology of Disease 2008 29 2 176 185 2-s2.0-38149092393 10.1016/j.nbd.2007.08.014
49. Pires R. G. W., Pereira S. R. C., Oliveira-Silva I. F., Franco G. C., Ribeiro A. M., Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome. Behavioural Brain Research 2005 162 1 11 21 2-s2.0-19444376187 10.1016/j.bbr.2005.02.032 (Pubitemid 40726276)
50. Nakagawasai O., Tadano T., Hozumi S., Tan-No K., Niijima F., Kisara K., Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency. Brain Research Bulletin 2000 52 3 189 196 2-s2.0-0034060762 10.1016/S0361-9230(00)00248-3 (Pubitemid 30261508)
51. Nakagawasai O., Tadano T., Hozumi S., Taniguchi R., Tan-No K., Esashi A., Niijima F., Kisara K., Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. Life Sciences 2001 69 10 1181 1191 2-s2.0-0035958619 10.1016/S0024-3205(01)01206-1 (Pubitemid 32722083)
52. Roland J. J., Savage L. M., The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia. Neuroscience 2009 160 1 32 41 2-s2.0-63649100987 10.1016/j.neuroscience.2009.02. 044
53. Todd K. G., Butterworth R. F., Mechanisms of selective neuronal cell death due to thiamine deficiency. Annals of the New York Academy of Sciences 1999 893 404 411 2-s2.0-0033401857 (Pubitemid 30038116)
54. Szutowicz A., Bielarczyk H., Gul S., Ronowska A., Pawełczyk T., Jankowska-Kulawy A., Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. Metabolic Brain Disease 2006 21 2-3 149 161 2-s2.0-33750433463
55. Nakagawasai O., Behavioral and neurochemical alterations following thiamine deficiency in rodents: relationship to functions of cholinergic neurons. Yakugaku Zasshi 2005 125 7 549 554 2-s2.0-25144513147 10.1248/yakushi.125.549 (Pubitemid 41350654)
56. Holowach J., Kauffman F., Ikossi M. G., Thomas C., McDougal D. B. Jr., The effects of a thiamine antagonist, pyrithiamine, on levels of selected metabolic intermediates and on activities of thiamine-dependent enzymes in brain and liver. Journal of Neurochemistry 1968 15 7 621 631 2-s2.0-0014314006
57. Langlais P. J., Zhang S.-X., Savage L. M., Neuropathology of thiamine deficiency: an update on the comparative analysis of human disorders and experimental models. Metabolic Brain Disease 1996 11 1 19 37 2-s2.0-0029880676 10.1007/BF02080929 (Pubitemid 26101010)
58. Watanabe I., Pyrithiamine-induced acute thiamine-deficient encephalopathy in the mouse. Experimental and Molecular Pathology 1978 28 3 381 394 2-s2.0-0018147759 (Pubitemid 8357250)
59. Witt E. D., Neuroanatomical consequences of thiamine deficiency: a comparative analysis. Alcohol and Alcoholism 1985 20 2 201 221 2-s2.0-0022258557 (Pubitemid 15013237)
60. Troncoso J. C., Johnston M. V., Hess K. M., Griffin J. W., Price D. L., Model of Wernicke's encephalopathy. Archives of Neurology 1981 38 6 350 354 2-s2.0-0019447494 (Pubitemid 11070204)
61. Vetreno R. P., Hall J. M., Savage L. M., Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment. Neurobiology of Learning and Memory 2011 96 4 596 608 2-s2.0-82355161488 10.1016/j.nlm.2011.01.003
62. Butterworth R. F., Heroux M., Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes. Journal of Neurochemistry 1989 52 4 1079 1084 2-s2.0-0024502089 (Pubitemid 19085929)
63. Pitkin S. R., Savage L. M., Aging potentiates the acute and chronic neurological symptoms of pyrithiamine-induced thiamine deficiency in the rodent. Behavioural Brain Research 2001 119 2 167 177 2-s2.0-0035857803 10.1016/S0166-4328(00)00350-8 (Pubitemid 32101458)
64. Pitkin S. R., Savage L. M., Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. Behavioural Brain Research 2004 148 1-2 93 105 2-s2.0-0347626246 10.1016/S0166-4328(03) 00208-0 (Pubitemid 37543659)
65. Savage L. M., Chang Q., Gold P. E., Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing. Learning and Memory 2003 10 4 242 246 2-s2.0-0042971961 10.1101/lm.60003 (Pubitemid 37013062)
66. Roland J. J., Mark K., Vetreno R. P., Savage L. M., Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia. Brain Research 2008 1234 116 127 2-s2.0-52049110725 10.1016/j.brainres.2008.07.090
67. Anzalone S., Vetreno R. P., Ramos R. L., Savage L. M., Cortical cholinergic abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat. European Journal of Neuroscience 2010 32 5 847 858 2-s2.0-77956398513 10.1111/j.1460-9568.2010. 07358.x
68. Reed L. J., Lasserson D., Marsden P., Stanhope N., Stevens T., Bello F., Kingsley D., Colchester A., Kopelman M. D., FDG-PET findings in the Wernicke-Korsakoff syndrome. Cortex 2003 39 4-5 1027 1045 2-s2.0-0242300685 (Pubitemid 37351080)
69. Mair R. G., Lacourse D. M., Radio-frequency lesions of the thalamus produce delayed-nonmatching-to-sample impairments comparable to pyrithiamine-induced encephalopathy in rats. Behavioral Neuroscience 1992 106 4 634 645 2-s2.0-0026778104 10.1037/0735-7044.106.4.634
70. Burk J. A., Mair R. G., Thalamic Amnesia reconsidered: excitotoxic lesions of the intralaminar nuclei, but not the mediodorsal nucleus, disrupt placed delayed matching-to- sample performance in rats (Rattus norvegicus). Behavioral Neuroscience 1998 112 1 54 67 2-s2.0-0031931467 10.1037/0735-7044. 112.1.54 (Pubitemid 28106754)
71. Walsh T. J., Herzog C. D., Gandhi C., Stackman R. W., Wiley R. G., Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits. Brain Research 1996 726 1-2 69 79 2-s2.0-0030575306 10.1016/S0006-8993(96)00271-5 (Pubitemid 26292232)
72. Chang Q., Gold P. E., Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Hippocampus 2004 14 2 170 179 2-s2.0-1842729461 10.1002/hipo.10160 (Pubitemid 38477104)
73. Todd K. G., Butterworth R. F., In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy. Methods 2001 23 1 55 61 2-s2.0-0034842747 10.1006/meth.2000.1105 (Pubitemid 32846016)
74. Hazell A. S., Butterworth R. F., Hakim A. M., Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency. Journal of Neurochemistry 1993 61 3 1155 1158 2-s2.0-0027228515 (Pubitemid 23241260)
75. Langlais P. J., Zhang S. X. Z., Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. Journal of Neurochemistry 1993 61 6 2175 2182 2-s2.0-0027488030 10.1111/j.1471-4159.1993.tb07457.x (Pubitemid 23354076)
76. Zhang S. X., Weilersbacher G. S., Henderson S. W., Corso T., Olney J. W., Langlais P. J., Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. Journal of Neuropathology and Experimental Neurology 1995 54 2 255 267 2-s2.0-0028964458
77. Todd K. G., Butterworth R. F., Evaluation of the role of NMDA-mediated excitotoxicity in the selective neuronal loss in experimental Wernicke encephalopathy. Experimental Neurology 1998 149 1 130 138 2-s2.0-0031889545 10.1006/exnr.1997.6677 (Pubitemid 28091022)
78. Gibson G. E., Zhang H., Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration. Neurochemistry International 2002 40 6 493 504 2-s2.0-0036176566 10.1016/S0197-0186(01)00120-6 (Pubitemid 34159150)
79. McKinney M., Brain cholinergic vulnerability: relevance to behavior and disease. Biochemical Pharmacology 2005 70 8 1115 1124 2-s2.0-24944524929 10.1016/j.bcp.2005.05.019 (Pubitemid 41317506)
80. Harper C., The neurotoxicity of alcohol. Human and Experimental Toxicology 2007 26 3 251 257 2-s2.0-33947405607 10.1177/0960327107070499 (Pubitemid 46456803)
81. Mair W. G. P., Warrington E. K., Weiskrantz L., Memory disorder in Korsakoff's psychosis: a neuropathological and neuropsychological investigation of two cases. Brain 1979 102 4 749 783 2-s2.0-0018575595 (Pubitemid 10205611)
82. Mayes A. R., Meudell P. R., Mann D., Pickering A., Location of lesions in Korsakoff's syndrome: neuropsychological and neuropathological data on two patients. Cortex 1988 24 3 367 388 2-s2.0-0023705530
83. Jacobson R. R., Lishman W. A., Cortical and diencephalic lesions in Korsakoff's syndrome: a clinical and CT scan study. Psychological Medicine 1990 20 1 63 75 2-s2.0-0025305616 (Pubitemid 20089616)
84. Sullivan E. V., Pfefferbaum A., Neuroimaging of the Wernicke-Korsakoff syndrome. Alcohol and Alcoholism 2009 44 2 155 165 2-s2.0-61449185505 10.1093/alcalc/agn103
85. Pfefferbaum A., Sullivan E. V., Mathalon D. H., Lim K. O., Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcoholism 1997 21 3 521 529 2-s2.0-0031011614 (Pubitemid 27217197)
86. Ratti M. T., Bo P., Giardini A., Soragna D., Chronic alcoholism and the frontal lobe: which executive functions are impaired? Acta Neurologica Scandinavica 2002 105 4 276 281 2-s2.0-0036110016 10.1034/j.1600-0404.2002. 0o315.x (Pubitemid 34407230)
87. Langlais P. J., Mair R. G., Protective effects of the glutamate antagonist MK-801 on pyrithiamine-induced lesions and amino acid changes in rat brain. Journal of Neuroscience 1990 10 5 1664 1674 2-s2.0-0025426344
88. Langlais P. J., Savage L. M., Thiamine deficiency in rats produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter. Behavioural Brain Research 1995 68 1 75 89 2-s2.0-0028930149 10.1016/0166-4328(94)00162-9
89. Harding A., Halliday G., Caine D., Kril J., Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 2000 123 1 141 154 2-s2.0-0033985319 (Pubitemid 30037976)
90. Markowitsch H. J., Diencephalic amnesia: a reorientation towards tracts? Brain Research Reviews 1988 13 4 351 370 2-s2.0-0024226609 (Pubitemid 19024353)
91. Savage L. M., Hall J. M., Vetreno R. P., Anterior thalamic lesions alter both hippocampaldependent behavior and hippocampal acetylcholine release in the rat. Learning and Memory 2011 18 12 751 758 2-s2.0-81755181069 10.1101/lm.023887.111
92. Nardone R., Bergmann J., De Blasi P., Kronbichler M., Kraus J., Caleri F., Tezzon F., Ladurner G., Golaszewski S., Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study. Journal of Neural Transmission 2010 117 3 385 391 2-s2.0-77952427477 10.1007/s00702-009-0347-1
93. McEntee W. J., Mair R. G., Memory enhancement in Korsakoff's psychosis by clonidine: further evidence for a noradrenergic deficit. Annals of Neurology 1980 7 5 466 470 2-s2.0-0018856249 (Pubitemid 10073127)
94. Martin P. R., Adinoff B., Lane E., Stapleton J. M., Bone G. A. H., Weingartner H., Linnoila M., Eckardt M. J., Fluvoxamine treatment of alcoholic amnestic disorder. European Neuropsychopharmacology 1995 5 1 27 33 2-s2.0-0028930892 10.1016/0924-977X(94)00129-Y
95. Halliday G. M., Ellis J., Harper C., The locus coeruleus and memory: a study of chronic alcoholics with and without the memory impairment of Korsakoff's psychosis. Brain Research 1992 598 1-2 33 37 2-s2.0-0027051922 10.1016/0006-8993(92)90164-5 (Pubitemid 23013041)