Low dose of methylmercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells

Journal of Toxicological Sciences

Volumn 38, Issue 6, 2013, Pages 931-935

  Watanabe, Jun ^a   Nakamachi, Tomoya ^a   Ohtaki, Hirokazu ^a   Naganuma, Akira ^b   Shioda, Seiji ^a   Nakajo, Shigeo ^a,c  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

Apoptosis; Caspase; DNA ladder; Methylmercury; Neural progenitor cell

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; METHYLMERCURY; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; Z VAD FMK;

ANIMAL CELL; APOPTOSIS; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DNA FRAGMENTATION; GEL ELECTROPHORESIS; IMMUNOBLOTTING; MOUSE; NEURAL STEM CELL; NONHUMAN; TELENCEPHALON;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; METHYLMERCURY COMPOUNDS; MICE; MICE, INBRED ICR; NEURAL STEM CELLS; TELENCEPHALON; TIME FACTORS;

EID: 84887431544     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.931     Document Type: Article

References (22)

1. Burke, K., Cheng, Y., Li, B., Petrov, A., Joshi, P., Berman, R.F., Reuhl, K.R and DiCicco-Bloom, E. (2006): Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology, 27, 970-981.
2. Castoldi, A.F., Barni, S., Turin, I., Gandini, C. and Manzo, L. (2000): Early acute necrosis, delayed apoptosis and cytoskele- tal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J. Neurosci. Res., 59, 775-787.
3. Fernandes-Alnemri, T., Litwack, G. and Alnemri, E.S. (1994): CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem., 269, 30761-30764.
4. JNftsu, Y.T., Wolter, K.G. and Youle, R.J. (1997): Cytosol-to-mem- brane redistribution of Bax and Bcl-XL during apoptosis. Proc. Nat. Acad. Sci. USA, 94, 3668-3672.
5. Kuo, T.C. and Lin-Shiau, S.Y. (2004): Early acute necrosis and delayed apoptosis induced by methyl mercury in murine peritoneal neutrophils. Basic Clin. Pharmacol. Toxicol., 94, 274-281.
6. Linnet, K.M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T.B., Rodriguez, A., Kotimaa, A., Moilanen, I., Thomsen, PH., Olsen, J. and Jarvelin, M.R. (2003): Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am. J. Psychiatry, 160, 1028-1040.
7. Miura, K., Suzuki, K. and Imura, N. (1978): Effects of methylmercury on mitotic mouse glioma cells. Environ. Res., 17, 453-471.
8. Moore, S.J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D.J., Montgomery, T. and Dean, J.C. (2000): A clinical study of 57 children with fetal anticonvulsant syndromes. J. Med. Genet., 37, 489-497.
9. Nicholson, D.W., Ali, A., Thomberry, N.A., Vaillancourt J.P., Ding C.K., Gallant, M., Gareau, Y., Griffin, P.R., Labelle, M., Lazebnik, Y.A., Munday, N.A., Raju, S.N., Smulson, M.E., Yamin, T., Yu, V.L. and Miller, D.K. (1995): Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43.
10. Ponce, R.A., Kavanagh, T.J., Mottet, N.K., Whittaker, S.G. and Faustman, E.M. (1994): Effects of methyl mercury on the cell cycle of primary rat CNS cells in vitro. Toxicol. Appl. Pharmacol., 127, 83-90.
11. Philip, W.D., Gary, J.M. and Bernard, W. (2004): Mercury expor- sure and child development 14 outcomes. Pediatrics, 113, 1023-1029.
12. Rodier, P.M., Aschner, M. and Sager, P.R. (1984): Mitotic arrest in the developing CNS after prenatal exposure to methylmercury. Neurobehav. Toxicol. Teratol., 6, 379-385.
13. Rogan, W.J., Gladen, B.C., Hung, K.L., Koong, S.L., Shih, L.Y., Tayrlor, J.S., Wu, Y.C., Yang, D., Ragan, N.B. and Hsu, C.C. (1988): Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science, 241, 334-336.
14. Shih, C.M., Ko, W.C., Yang, L.Y., Lin, C.J., Wu, J.S., Lo, T.Y., Wang, S.H. and Chen, C.T. (2005): Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy. Ann. N.Y. Acad. Sci., 1042, 488-496.
15. Stromland, K., Nordin, V., Miller, M., Akerstrom, B. and Gillberg, C. (1994): Autism in thalidomide embryopathy: a population study. Dev. Med. Child Neurol., 36, 351-356.
16. Tamm, C., Duckworth, J., Hermanson, O. and Ceccatelli, S. (2006): High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J. Neurochem., 97, 69-78.
17. Thapar, A., Fowler, T., Rice, F., Scourfield, J., van den Bree, M., Thomas, H., Harold, G. and Hay, D. (2003): Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Am. J. Psychiatry, 160, 1985-1989.
18. Watanabe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S. and Nakajo, S. (2006a): Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C. J. Neurosci. Res., 84, 1645-1655.
19. Watanabe, J., Ohno, F., Shioda, S., Kikuyama, S., Nakaya, K. and Nakajo, S. (2006b): Involvement ofprotein kinase C in the PAC- AP-induced differentiation of neural stem cells into astrocytes. Ann. N.Y. Acad. Sci., 1070, 597-601.
20. Watanabe, J., Nakamachi, T., Ogawa, T., Naganuma, A., Nakamura, M., Shioda, S. and Nakajo, S. (2009): Characterization of Antioxidant Protection of Cultured Neural Progenitor Cells Against Methylmercury Toxicity. J. Toxicol. Sci., 34, 315-325.
21. Xu, M., Yan, C., Tian, Y., Yuan, X. and Shen, X. (2010): Effects of low level of methylmercury on proliferation of cortical progenitor cells. Brain Res., 1359, 272-280.
22. Yolton, K., Dietrich, K., Auinger, P., Lanphear, B.P. and Hornung, R. (2005): Exposure to environmental tobacco smoke and cognitive abilities among U.S. children and adolescents. Environ. Health Perspect., 113, 98-103.