Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: A vaccine candidate for human intestinal schistosomiasis

Human Vaccines and Immunotherapeutics

Volumn 9, Issue 11, 2013, Pages 2342-2350

  Curti, Elena ^a,b,f   Kwityn, Clifford ^a,b   Zhan, Bin ^a,b   Gillespie, Portia ^a,b   Brelsford, Jill ^c   Deumic, Vehid ^c   Plieskatt, Jordan ^c   Rezende, Wanderson C ^a,b   Tsao, Eric ^d   Kalampanayil, Bose ^d   Hotez, Peter J ^a,b,e   Bottazzi, Maria Elena ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d AERAS   (United States)

^e RICE UNIVERSITY   (United States)

^f Beckman Coulter Inc   (United States)

Author keywords

Neglected tropical diseases; Pichia Pastoris; Recombinant protein; Schistosoma mansoni; Schistosomiasis; Sm TSP 2; Vaccine

Indexed keywords

RECOMBINANT PROTEIN; RECOMBINANT VACCINE; TSP 2 PROTEIN; UNCLASSIFIED DRUG; HELMINTH PROTEIN; PARASITE ANTIGEN; TETRASPANIN; TSP-2 PROTEIN, SCHISTOSOMA MANSONI; VACCINE;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR SPACE; FERMENTATION TECHNIQUE; INTESTINAL SCHISTOSOMIASIS; MOLECULAR CLONING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REPRODUCIBILITY; SCALE UP; SCHISTOSOMIASIS; ANIMAL; BIOSYNTHESIS; BIOTECHNOLOGY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHARMACEUTICS; PICHIA; PROCEDURES; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

ANIMALS; ANTIGENS, HELMINTH; BIOTECHNOLOGY; GENE EXPRESSION; HELMINTH PROTEINS; PICHIA; RECOMBINANT PROTEINS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TECHNOLOGY, PHARMACEUTICAL; TETRASPANINS; VACCINES;

EID: 84887428083     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25787     Document Type: Article

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