Hospital-acquired pneumonia in critically ill children: Incidence, risk factors, outcome and diagnosis with insight on the novel diagnostic technique of multiplex polymerase chain reaction

Egyptian Journal of Medical Human Genetics

Volumn 13, Issue 1, 2012, Pages 99-105

  Mansour, Mervat Gamal Eldin ^a   Bendary, Sherin ^b  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Bacterial diagnosis; Hospital acquired pneumonia; M PCR; Outcome; Risk factors

Indexed keywords

ACINETOBACTER; ADULT; ARTICLE; ARTIFICIAL VENTILATION; BACTERIUM CULTURE; BLOOD ANALYSIS; CHILDHOOD DISEASE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENDOTRACHEAL INTUBATION; FEMALE; GASTROESOPHAGEAL REFLUX; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL ADMISSION; HUMAN; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; MORTALITY; MULTIPLEX POLYMERASE CHAIN REACTION; OUTCOME ASSESSMENT; PREDICTIVE VALUE; RISK ASSESSMENT; SEDATION; SENSITIVITY AND SPECIFICITY; TRACHEAL ASPIRATION PROCEDURE;

ACINETOBACTER; BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 84887408145     PISSN: 11108630     EISSN: 20902441     Source Type: Journal    
DOI: 10.1016/j.ejmhg.2012.01.002     Document Type: Article

References (32)

1. Bartlett JG. Hospital-acquired pneumonia: the Merck Manual for healthcare professionals. 2008. http://www.merck.com/mmpe/sec05/ch052/ch052c.html.
2. Alp E., Güven M., Yi{dotless}ldi{dotless}z O., Aygen B., Voss A., Doganay M. Incidence, risk factors and mortality of nosocomial pneumonia in Intensive Care Units: a prospective study. Ann Clin Microbiol Antimicrob 2004, 3:17.
3. Dodek P., Keenan S., Cook D., Heyland D., Jacka M., Hand L. For the Canadian Critical Care Trials Group and the Canadian Critical Care Society. Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med 2004, 141:305-313.
4. Lisboa T., Rello J. Diagnosis of ventilator-associated pneumonia: is there a gold standard and a simple approach?. Curr Opin Infect Dis 2008, 21(2):174-178.
5. Leteurtre S., Martinot A., Duhamel A., et al. Validation of the pediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003, 362:192-197.
6. Alicia N.K., Pamela A.L. Hospital-acquired pneumonia: pathophysiology, diagnosis, and treatment. Surg Clin North Am 2009, 89:439-461.
7. Swoboda S.M., Dixon T., Lipsett P.A. Can the clinical pulmonary infection score impact ICU antibiotic days?. Surg Infect (Larchmt) 2006, 7:331-339.
8. Kumar S., Wang L., Fan J., Kraft A., Bose M.E., Tiwari S., et al. Detection of 11 common viral and bacterial pathogens causing community-acquired pneumonia or sepsis in asymptomatic patients by using a multiplex reverse transcription-PCR assay with manual (enzyme hybridization) or automated (electronic microarray) detection. J Clin Microbiol 2008, 46(9):3063-3072.
9. Kurupati P., Chow C., Kumarasinghe G., Poh C.L. Rapid detection of Klebsiella pneumoniae from blood culture bottles by real-time PCR. J Clin Microbiol 2004, 42(3):1337-1340.
10. Qin X., Emerson J., Stapp J., Stapp L., Abe P., Burns J.L. Use of real-time PCR with multiple targets to identify Pseudomonas aeruginosa and other non-fermenting Gram-negative bacilli from patients with cystic fibrosis. J Clin Microbiol 2003, 1(9):4312-4317.
11. Rosenthal V.D., Maki D.G., Mehta A., Alvarez-Moreno C., Leblebicioglu H., Higuera F. International Nosocomial Infection Control Consortium report, data summary for 2002-2007. Am J Infect Control 2008, 36(9):627-637.
12. Chawla R. Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries. Am J Infect Control 2008, 36(4):S93-S100.
13. Patra P.K., Jayashree M., Singhi S., Ray P., Saxena A.K. Nosocomial pneumonia in a pediatric intensive care unit. Indian Pediatr 2007, 44:511-518.
14. Apfalter P., Stoiser B., Barousch W., Nehr M., Kramer L., Burgmann H. Community-acquired bacteria frequently detected by means of quantitative polymerase chain reaction in nosocomial early-onset ventilator-associated pneumonia. Crit Care Med 2005, 33(7):1492-1498.
15. Osenthal V.D., Maki D.G., Mehta A., Alvarez-Moreno C., Leblebicioglu H., Higuera F. International Nosocomial Infection Control Consortium report, data summary for 2002-2007, issued January 2008. Am J Infect Control 2008, 36(9):627-637.
16. Nithiwathanapong C., Reungrongrat S., Ukarapol N. Prevalence and risk factors of stress-induced gastrointestinal bleeding in critically ill children. World J Gastroenterol 2005, 11(43):6839-6842.
17. Khaled Amro Re-intubation increases ventilator-associated pneumonia in pediatric intensive care unit patients. RMJ 2008, 33(2):145-149.
18. Srinivasan R., Asselin J., Gildengorin G., Kronish J.W., Flori H.R. A prospective study of ventilator-associated pneumonia in children. Pediatrics 2009, 123(4):1108-1115.
19. Martinbiancho J.K., Carvalho P.R.A., Trotta E.D.A., Schweiger A.P., Rau R., Moreira L.B. Evidence of safety of chloral hydrate for prolonged sedation in PICU in a tertiary teaching hospital in southern Brazil. Eur J Clin Pharmacol 2009, 65(12):1253-1258.
20. Cunha B.A. Legionnaires' disease: clinical differentiation from typical and other atypical pneumonias. Infect Dis Clin North Am 2010, 24(1):73-105.
21. Sharma H., Singh D., Pooni P., Mohan U. A study of profile of ventilator-associated pneumonia in children in Punjab. J Trop Pediatr 2009, 55(6):393-395.
22. Augustyn B. Ventilator-associated pneumonia risk factors and prevention. Crit Care Nurse 2007, 27:32-39.
23. Sierra R., Benítez E., León C., Rello J. Prevention and diagnosis of ventilator-associated pneumonia. A survey on current practices in southern Spanish ICUs. Chest 2005, 128:1667-1673.
24. Alp E., Voss A. Ventilator associated pneumonia and infection control. Ann Clin Microbiol Antimicrob 2006, 5(7).
25. Lone R., Shah A., Kadri S.M., Lone S., Faisal S. Nosocomial multi-drug-resistant acinetobacter infections - clinical findings, risk factors and demographic characteristics. Bangladesh J Med Microbiol 2009, 3(1):34-38.
26. Laurent C., Rodriguez-Villalobos H., Rost F., Strale H., Vincent J.L., Deplano A., et al. Intensive care unit outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae controlled by cohorting patients and reinforcing infection control measures. Infect Control Hosp Epidemiol 2008, 29:517-552.
27. Park D.R. The microbiology of ventilator-associated pneumonia. Respir Care 2005, 50(6):742-763.
28. Weigelt J., Itani K., Stevens D., Lau W., Dryden M., Knirsch C. Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections. Antimicrob Agents Chemother 2005, 49:2260-2266.
29. Torres A., Ewig S., Lode H., Carlet J. Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med 2009, 35:9-29.
30. American Thoracic Society Documents Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171:388-416.
31. Strålin K., Korsgaard J., Olcén P. Evaluation of a multiplex PCR for bacterial pathogens applied to bronchoalveolar lavage. ERJ 2006, 28(3):568-575.
32. Hendolin P.H., Markkanen A., Ylikoski J., Wahlfors J. Use of multiplex PCR for simultaneous detection of four bacterial species in middle ear effusions. J Clin Microbiol 1997, 35(11):2854-2858.