메뉴 건너뛰기




Volumn 7, Issue 11, 2013, Pages 2602-2605

Acinetobacter baumannii: A brief account of mechanisms of multidrug resistance and current and future therapeutic management

Author keywords

A. baumannii; Colistin; CRAB; MDR Ab

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; COLISTIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DORIPENEM; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; POLYMYXIN B; POLYMYXIN DERIVATIVE; PORIN; PROTEIN PARC; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; SULBACTAM; SULTAMICILLIN; TIGECYCLINE; TOBRAMYCIN; VANCOMYCIN;

EID: 84887357663     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2013/6337.3626     Document Type: Review
Times cited : (62)

References (42)
  • 1
    • 47949089607 scopus 로고    scopus 로고
    • Acinetobacter baumannii: Emergence of a successful pathogen
    • Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. 2008;21(3):538-582.
    • (2008) Clin Microbiol Rev. , vol.21 , Issue.3 , pp. 538-582
    • Peleg, A.Y.1    Seifert, H.2    Paterson, D.L.3
  • 2
    • 4544327051 scopus 로고    scopus 로고
    • Antimicrobial resistance of Acinetobacter spp. in Europe
    • ARPAC Steering Group
    • van Looveren M, Goossens H; ARPAC Steering Group. "Antimicrobial resistance of Acinetobacter spp. in Europe. " Clinical Microbiology and Infection. 2004; 10 (8):684-704.
    • (2004) Clinical Microbiology and Infection. , vol.10 , Issue.8 , pp. 684-704
    • van Looveren, M.1    Goossens, H.2
  • 3
  • 4
    • 0031724845 scopus 로고    scopus 로고
    • Effect of desiccation on the ultrastructural appearances of Acinetobacter baumannii and Acinetobacter lwoffii
    • Houang ET, Sormunen RT, Lai L, Chan CY, Leong AS. Effect of desiccation on the ultrastructural appearances of Acinetobacter baumannii and Acinetobacter lwoffii. J. Clin. Pathol. 1998;51(10):786-8.
    • (1998) J. Clin. Pathol. , vol.51 , Issue.10 , pp. 786-788
    • Houang, E.T.1    Sormunen, R.T.2    Lai, L.3    Chan, C.Y.4    Leong, A.S.5
  • 6
    • 33845248862 scopus 로고    scopus 로고
    • Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center
    • Hujer KM, Hujer AM, Hulten EA, Bajaksouzian S, Adams JM, Donskey CS, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrobial Agents and Chemotherapy. 2006;50(12):4114-123.
    • (2006) Antimicrobial Agents and Chemotherapy. , vol.50 , Issue.12 , pp. 4114-4123
    • Hujer, K.M.1    Hujer, A.M.2    Hulten, E.A.3    Bajaksouzian, S.4    Adams, J.M.5    Donskey, C.S.6
  • 7
    • 35348832399 scopus 로고    scopus 로고
    • Antimicrobial resistance among gram negative bacilli as causes of infections in intensive care unit patients in the United States between 1993 and 2004
    • Lockhart SR, Abramson MA, Beekmann SE, Gallagher G, Riedel S, Diekema DJ, et al. Antimicrobial resistance among gram negative bacilli as causes of infections in intensive care unit patients in the United States between 1993 and 2004. J Clin Microbiol 2007; 45:3352-359.
    • (2007) J Clin Microbiol , vol.45 , pp. 3352-3359
    • Lockhart, S.R.1    Abramson, M.A.2    Beekmann, S.E.3    Gallagher, G.4    Riedel, S.5    Diekema, D.J.6
  • 8
    • 33747625237 scopus 로고    scopus 로고
    • Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa
    • Bonomo RA, Szabo D. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin Infect Dis 2006; 43(Suppl 2):49-56.
    • (2006) Clin Infect Dis , vol.43 , Issue.SUPPL. 2 , pp. 49-56
    • Bonomo, R.A.1    Szabo, D.2
  • 9
    • 33747589695 scopus 로고    scopus 로고
    • Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa
    • Rice LB. Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa. Clin Infect Dis. 2006; 43(Suppl 2):100-05.
    • (2006) Clin Infect Dis. , vol.43 , Issue.SUPPL. 2 , pp. 100-105
    • Rice, L.B.1
  • 10
    • 30344468763 scopus 로고    scopus 로고
    • OXA b-lactamases in Acinetobacter: The story so far
    • Brown S, Amyes S. OXA b-lactamases in Acinetobacter: the story so far. J Antimicrob Chemother. 2006; 57:1-3.
    • (2006) J Antimicrob Chemother. , vol.57 , pp. 1-3
    • Brown, S.1    Amyes, S.2
  • 12
    • 16244406203 scopus 로고    scopus 로고
    • Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: Natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
    • Mussi MA, Limansky AS, Viale AM. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob Agents Chemother. 2005; 49:1432-440.
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 1432-1440
    • Mussi, M.A.1    Limansky, A.S.2    Viale, A.M.3
  • 15
    • 33746585743 scopus 로고    scopus 로고
    • Carbapenem resistance in Acinetobacter baumannii: Mechanisms and epidemiology
    • Poirel L, Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect. 2006;12: 826-36.
    • (2006) Clin Microbiol Infect. , vol.12 , pp. 826-836
    • Poirel, L.1    Nordmann, P.2
  • 16
    • 68049099988 scopus 로고    scopus 로고
    • Carbapenem resistance in Acinetobacter baumannii: The molecular epidemic features of an emerging problem in health care facilities
    • Zarrilli R, Giannouli M, Tomasone F, Triassi M, Tsakris A. Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities. J Infect Dev Ctries. 2009; 3(5):335-41.
    • (2009) J Infect Dev Ctries. , vol.3 , Issue.5 , pp. 335-341
    • Zarrilli, R.1    Giannouli, M.2    Tomasone, F.3    Triassi, M.4    Tsakris, A.5
  • 17
    • 0027389658 scopus 로고
    • Effect of sulbactam on infections caused by imipenem-resistant Acinetobacter calcoaceticus biotype anitratus
    • Urban C, Go E, Mariano N, Berger BJ, Avraham I, Rubin D, et al. Effect of sulbactam on infections caused by imipenem-resistant Acinetobacter calcoaceticus biotype anitratus. J Infect Dis. 1993; 167(2):448-51.
    • (1993) J Infect Dis. , vol.167 , Issue.2 , pp. 448-451
    • Urban, C.1    Go, E.2    Mariano, N.3    Berger, B.J.4    Avraham, I.5    Rubin, D.6
  • 18
    • 0035150797 scopus 로고    scopus 로고
    • Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactam
    • Jellison TK, Mckinnon PS, Rybak MJ. Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactam. Pharmacotherapy. 2001; 21(2):142-48.
    • (2001) Pharmacotherapy. , vol.21 , Issue.2 , pp. 142-148
    • Jellison, T.K.1    McKinnon, P.S.2    Rybak, M.J.3
  • 19
    • 0141723346 scopus 로고    scopus 로고
    • Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: Risk factors and outcome with ampicillin-sulbactam treatment
    • Smolyakov R, Borer A, Riesenberg K, Schlaeffer F, Alkan M, Porath A, et al. Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment. J Hosp Infect. 2003; 54(1):32-38.
    • (2003) J Hosp Infect. , vol.54 , Issue.1 , pp. 32-38
    • Smolyakov, R.1    Borer, A.2    Riesenberg, K.3    Schlaeffer, F.4    Alkan, M.5    Porath, A.6
  • 20
    • 67349169225 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of tigecycline and comparators against bacterial isolates collected as part of the TEST study in Europe (2004-2007)
    • Norskov-Lauritsen N, Marchandin H, Dowzicky MJ. Antimicrobial susceptibility of tigecycline and comparators against bacterial isolates collected as part of the TEST study in Europe (2004-2007). Int J Antimicrob Agents. 2009; 34(2):121-30.
    • (2009) Int J Antimicrob Agents. , vol.34 , Issue.2 , pp. 121-130
    • Norskov-Lauritsen, N.1    Marchandin, H.2    Dowzicky, M.J.3
  • 23
    • 24744456341 scopus 로고    scopus 로고
    • Infections with Colistin baumannii Central Nervous System Multidrug-Resistant Acinetobacter
    • Katragkou A, Roilides E. Infections with Colistin baumannii Central Nervous System Multidrug-Resistant Acinetobacter J. Clin. Microbiol. 2005, 43(9):4916-917.
    • (2005) J Clin. Microbiol. , vol.43 , Issue.9 , pp. 4916-4917
    • Katragkou, A.1    Roilides, E.2
  • 24
    • 62749144463 scopus 로고    scopus 로고
    • Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
    • Gounden R, Bamford C, van Zyl-Smit R, Cohen K, Maartens G. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections. BMC Infect Dis, 2009; 9:26.
    • (2009) BMC Infect Dis , vol.9 , pp. 26
    • Gounden, R.1    Bamford, C.2    van Zyl-Smit, R.3    Cohen, K.4    Maartens, G.5
  • 25
    • 34247129544 scopus 로고    scopus 로고
    • Aerosolized tobramycin in the treatment of ventilator-associated pneumonia: A pilot study
    • Hallal A, Cohn SM, Namias N, Habib F, Baracco G, Manning RJ, et al. Aerosolized tobramycin in the treatment of ventilator-associated pneumonia: a pilot study. Surg Infect Larchmt, 2007; 8(1):73-82.
    • (2007) Surg Infect Larchmt , vol.8 , Issue.1 , pp. 73-82
    • Hallal, A.1    Cohn, S.M.2    Namias, N.3    Habib, F.4    Baracco, G.5    Manning, R.J.6
  • 26
    • 4143120992 scopus 로고    scopus 로고
    • Multidrug-resistant Acinetobacter infections: An emerging challenge to clinicians
    • Jain R, Danziger LH. Multidrug-resistant Acinetobacter infections: an emerging challenge to clinicians. Ann. Pharmacother, 2004;38:1449-459.
    • (2004) Ann. Pharmacother , vol.38 , pp. 1449-1459
    • Jain, R.1    Danziger, L.H.2
  • 27
    • 62749144052 scopus 로고    scopus 로고
    • Management of meningitis due to antibiotic-resistant Acinetobacter species
    • Kim BN, Peleg AY, Lodise TP, Lipman J, Li J, Nation R, et al. Management of meningitis due to antibiotic-resistant Acinetobacter species. Lancet Infect Dis. 2009;9(4):245-55.
    • (2009) Lancet Infect Dis. , vol.9 , Issue.4 , pp. 245-255
    • Kim, B.N.1    Peleg, A.Y.2    Lodise, T.P.3    Lipman, J.4    Li, J.5    Nation, R.6
  • 30
    • 34250861565 scopus 로고    scopus 로고
    • Ade ABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex
    • Ruzin A, Keeney D, Bradford PA. Ade ABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J Antimicrob Chemother. 2007; 59:1001-004.
    • (2007) J Antimicrob Chemother. , vol.59 , pp. 1001-1004
    • Ruzin, A.1    Keeney, D.2    Bradford, P.A.3
  • 31
    • 42549108748 scopus 로고    scopus 로고
    • Acinetobacter baumannii: Epidemiology, Anti-microbial Resistance, and Treatment Options
    • Maragakis LL, Perl TM. Acinetobacter baumannii: Epidemiology, Anti-microbial Resistance, and Treatment Options. Clinical Infectious Diseases. 2008; 46: 1254-263.
    • (2008) Clinical Infectious Diseases. , vol.46 , pp. 1254-1263
    • Maragakis, L.L.1    Perl, T.M.2
  • 32
    • 34250171728 scopus 로고    scopus 로고
    • Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii
    • Peleg AY, Adams J, Paterson DL. Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother 2007; 51:2065-069.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2065-2069
    • Peleg, A.Y.1    Adams, J.2    Paterson, D.L.3
  • 33
    • 35848952749 scopus 로고    scopus 로고
    • Combination carbapenem-sulbactam therapy for critically ill patients with multidrug-resistant Acinetobacter baumannii bacteremia: Four case reports and an in vitro combination synergy study
    • Nov
    • Lee NY, Wang CL, Chuang YC, Yu WL, Lee HC, Chang CM, et al. Combination carbapenem-sulbactam therapy for critically ill patients with multidrug-resistant Acinetobacter baumannii bacteremia: four case reports and an in vitro combination synergy study. Pharmacotherapy. 2007 Nov;27(11):1506-511.
    • (2007) Pharmacotherapy. , vol.27 , Issue.11 , pp. 1506-1511
    • Lee, N.Y.1    Wang, C.L.2    Chuang, Y.C.3    Yu, W.L.4    Lee, H.C.5    Chang, C.M.6
  • 34
    • 33747874139 scopus 로고    scopus 로고
    • Rifampicin/imipenem combination in the treatment of carbapenem-resistant Acinetobacterbaumannii infections
    • Saballs M, Pujol M, Tubau F, Peña C, Montero A, Domínguez MA, et al. Rifampicin/imipenem combination in the treatment of carbapenem-resistant Acinetobacterbaumannii infections. J Antimicrob Chemother. 2006;58(3):697-700.
    • (2006) J Antimicrob Chemother. , vol.58 , Issue.3 , pp. 697-700
    • Saballs, M.1    Pujol, M.2    Tubau, F.3    Peña, C.4    Montero, A.5    Domínguez, M.A.6
  • 36
    • 84876209645 scopus 로고    scopus 로고
    • Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains
    • O'Hara JA, Ambe LA, Casella LG, Townsend BM, Pelletier MR, Ernst RK, et al. Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains. Antimicrob Agents Chemother. 2013;57(5):2103-108.
    • (2013) Antimicrob Agents Chemother. , vol.57 , Issue.5 , pp. 2103-2108
    • O'Hara, J.A.1    Ambe, L.A.2    Casella, L.G.3    Townsend, B.M.4    Pelletier, M.R.5    Ernst, R.K.6
  • 37
    • 0037301438 scopus 로고    scopus 로고
    • Metallo-beta-lactamase inhibitors: Could they give old antibacterials new life? Curr
    • Toney JH. Metallo-beta-lactamase inhibitors: could they give old antibacterials new life? Curr. Opin. Investig. Drugs. 2003;4:115-16.
    • (2003) Opin. Investig. Drugs. , vol.4 , pp. 115-116
    • Toney, J.H.1
  • 38
    • 0037330532 scopus 로고    scopus 로고
    • Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes
    • Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD. Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. Chem Biol. 2003;10(2):189-96.
    • (2003) Chem Biol. , vol.10 , Issue.2 , pp. 189-196
    • Boehr, D.D.1    Draker, K.A.2    Koteva, K.3    Bains, M.4    Hancock, R.E.5    Wright, G.D.6
  • 39
    • 33646251815 scopus 로고    scopus 로고
    • Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
    • Piddock LJ. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev. 2006;19(2):382-402.
    • (2006) Clin Microbiol Rev. , vol.19 , Issue.2 , pp. 382-402
    • Piddock, L.J.1
  • 40
    • 14544282377 scopus 로고    scopus 로고
    • Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?
    • Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol. 2005;3(3):238-50.
    • (2005) Nat Rev Microbiol. , vol.3 , Issue.3 , pp. 238-250
    • Brogden, K.A.1
  • 41
    • 0033737068 scopus 로고    scopus 로고
    • Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii
    • Giacometti AO, Cirioni MS, Del Prete F, Barchiesi AM, Paggi E, Petrelli, et al. Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii. J Antimicrob Chemother. 2000;46:807-10.
    • (2000) J Antimicrob Chemother. , vol.46 , pp. 807-810
    • Giacometti, A.O.1    Cirioni, M.S.2    Del Prete, F.3    Barchiesi, A.M.4    Paggi, E.5    Petrelli6
  • 42
    • 84862677946 scopus 로고    scopus 로고
    • Colistin resistance of Acinetobacter baumannii: Clinical reports, mechanisms and antimicrobial strategies
    • Cai Y, Chai D, Wang R, Liang B, Bai N. Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies. J Antimicrob Chemother. 2012;67 (7):1607-615.
    • (2012) J Antimicrob Chemother. , vol.67 , Issue.7 , pp. 1607-1615
    • Cai, Y.1    Chai, D.2    Wang, R.3    Liang, B.4    Bai, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.