Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats

Neuroscience Letters

Volumn 556, Issue , 2013, Pages 93-98

  Câmara, Carlos C ^a,b   Ramos, Heitor F ^a   da Silva, Alan P ^a   Araújo, Celina V ^a   Gomes, Antoniela S ^a   Vale, Mariana L ^a   Barbosa, André Luiz R ^a   Ribeiro, Ronaldo A ^a   Brito, Gerly A C ^a   Costa, Carlos Maurício C ^a   Oriá, Reinaldo B ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b Federal Rural University of the Semi Arid   (Brazil)

Author keywords

Cytokine; Gabapentin; Inflammation; Neuropathic pain; Sciatic nerve

Indexed keywords

GABAPENTIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MYELOPEROXIDASE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; INFLAMMATION; MACROPHAGE MIGRATION; MALE; NERVE COMPRESSION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PAW EDEMA; PERIPHERAL INFLAMMATORY RESPONSE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

CYTOKINE; GABAPENTIN; INFLAMMATION; NEUROPATHIC PAIN; SCIATIC NERVE;

ADMINISTRATION, ORAL; AMINES; ANALGESICS; ANIMALS; CELL MOVEMENT; CONSTRICTION, PATHOLOGIC; CYCLOHEXANECARBOXYLIC ACIDS; CYTOKINES; EDEMA; GAMMA-AMINOBUTYRIC ACID; INFLAMMATION; MALE; MOTOR ACTIVITY; NEURALGIA; PERITONEAL CAVITY; RATS; RATS, WISTAR; SCIATIC NERVE;

EID: 84887352602     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.10.010     Document Type: Article

References (35)

1. Alves N.D., de Castro-Costa C.M., de Carvalho A.M., Santos F.J., Silveira D.G. Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. Arq. Neuropsiquiatr. 1999, 57:916-920.
2. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33:87-107.
3. Beuche W., Friede R.L. The role of non-resident cells in Wallerian degeneration. J. Neurocytol. 1984, 13:767-796.
4. Bruck W. The role of macrophages in Wallerian degeneration. Brain Pathol. 1997, 7:741-752.
5. Constantinescu C.S., Goodman D.B., Hilliard B., Wysocka M., Cohen J.A. Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products. Neurosci. Lett. 2000, 287:171-174.
6. de Souza G.E., Ferreira S.H. Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity. Agents Actions 1985, 17:97-103.
7. De la O-Arciniega M., Diaz-Reval M.I., Cortes-Arroyo A.R., Dominguez-Ramirez A.M., Lopez-Munoz F.J. Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury. Pharmacol. Biochem. Behav. 2009, 92:457-464.
8. George A., Kleinschnitz C., Zelenka M., Brinkhoff J., Stoll G., Sommer C. Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein. Exp. Neurol. 2004, 188:187-191.
9. George A., Marziniak M., Schafers M., Toyka K.V., Sommer C. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain 2000, 88:267-275.
10. Guenard V., Dinarello C.A., Weston P.J., Aebischer P. Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel. J. Neurosci. Res. 1991, 29:396-400.
11. Guindon J., Walczak J.S., Beaulieu P. Recent advances in the pharmacological management of pain. Drugs 2007, 67:2121-2133.
12. Gustafsson H., Flood K., Berge O.G., Brodin E., Olgart L., Stiller C.O. Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. Exp. Neurol. 2003, 182:427-434.
13. Hahm T.S., Ahn H.J., Bae C.D., Kim H.S., Lim S.W., Cho H.S., Lee S.M., Sim W.S., Kim J.A., Gwak M.S., Choi S.J. Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. J. Korean Med. Sci. 2009, 24:146-151.
14. Hendrich J., Van Minh A.T., Heblich F., Nieto-Rostro M., Watschinger K., Striessnig J., Wratten J., Davies A., Dolphin A.C. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:3628-3633.
15. Hota D., Bansal V., Pattanaik S. Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find. Exp. Clin. Pharmacol. 2007, 29:443-446.
16. Hurley R.W., Chatterjea D., Rose F.M., Taylor C.P., Hammond D.L. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia. Anesthesiology 2002, 97:1263-1273.
17. Kayser V., Christensen D. Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. Pain 2000, 88:53-60.
18. LaBuda C.J., Little P.J. Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J. Neurosci. Methods 2005, 144:175-181.
19. Liefner M., Siebert H., Sachse T., Michel U., Kollias G., Bruck W. The role of TNF-alpha during Wallerian degeneration. J. Neuroimmunol. 2000, 108:147-152.
20. Lima-Junior R.C., Figueiredo A.A., Freitas H.C., Melo M.L., Wong D.V., Leite C.A., Medeiros R.P., Marques-Neto R.D., Vale M.L., Brito G.A., Oria R.B., Souza M.H., Cunha F.Q., Ribeiro R.A. Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation. Cancer Chemother. Pharmacol. 2012, 69:931-942.
21. Lindholm D., Heumann R., Meyer M., Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 1987, 330:658-659.
22. Liu L.Y., Zheng H., Xiao H.L., She Z.J., Zhao S.M., Chen Z.L., Zhou G.M. Comparison of blood-nerve barrier disruption and matrix metalloprotease-9 expression in injured central and peripheral nerves in mice. Neurosci. Lett. 2008, 434:155-159.
23. McGeeney B.E. Pharmacological management of neuropathic pain in older adults: an update on peripherally and centrally acting agents. J. Pain Symptom Manage. 2009, 38:S15-S27.
24. Mixcoatl-Zecuatl T., Flores-Murrieta F.J., Granados-Soto V. The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. Eur. J. Pharmacol. 2006, 531:87-95.
25. Nadeau S., Filali M., Zhang J., Kerr B.J., Rivest S., Soulet D., Iwakura Y., de Rivero Vaccari J.P., Keane R.W., Lacroix S. Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1{beta} and TNF: implications for neuropathic pain. J. Neurosci. 2011, 31:12533-12542.
26. O'Connor A.B., Dworkin R.H. Treatment of neuropathic pain: an overview of recent guidelines. Am. J. Med. 2009, 122:S22-S32.
27. Pirke K.M., Broocks A., Wilckens T., Marquard R., Schweiger U. Starvation-induced hyperactivity in the rat: the role of endocrine and neurotransmitter changes. Neurosci. Biobehav. Rev. 1993, 17:287-294.
28. Qin Y., Cheng C., Wang H., Shao X., Gao Y., Shen A. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochem. Res. 2008, 33:1077-1084.
29. Rao M.L., Clarenbach P., Vahlensieck M., Kratzschmar S. Gabapentin augments whole blood serotonin in healthy young men. J. Neural Transm. 1988, 73:129-134.
30. Sacerdote P., Franchi S., Moretti S., Castelli M., Procacci P., Magnaghi V., Panerai A.E. Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain. J. Neuroimmune Pharmacol. 2013, 8:202-211.
31. Shubayev V.I., Myers R.R. Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res. 2000, 855:83-89.
32. Sommer C., Lalonde A., Heckman H.M., Rodriguez M., Myers R.R. Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J. Neuropathol. Exp. Neurol. 1995, 54:635-643.
33. Temporin K., Tanaka H., Kuroda Y., Okada K., Yachi K., Moritomo H., Murase T., Yoshikawa H. Interleukin-1 beta promotes sensory nerve regeneration after sciatic nerve injury. Neurosci. Lett. 2008, 440:130-133.
34. Vargas M.E., Barres B.A. Why is Wallerian degeneration in the CNS so slow?. Annu. Rev. Neurosci. 2007, 30:153-179.
35. Zanella J.M., Burright E.N., Hildebrand K., Hobot C., Cox M., Christoferson L., McKay W.F. Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model. Spine (Phila Pa 1976) 2008, 33:227-234.