Measuring dopaminergic function in the 6-OHDA-lesioned rat: A comparison of PET and microdialysis

EJNMMI Research

Volumn 3, Issue 1, 2013, Pages 1-11

  Walker, Matthew D ^a   Dinelle, Katherine ^a   Kornelsen, Rick ^a   Lee, Anna ^a   Farrer, Matthew J ^a   Stoessl, A Jon ^a   Sossi, Vesna ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

6 OHDA lesion; Dopamine synthesis; FDOPA; Microdialysis; Parkinson's disease; PET

Indexed keywords

6 FLUORODOPA F 18; DIHYDROTETRABENAZINE; DIHYDROTETRABENAZINE C 11; DOPAMINE; LEVODOPA; OXIDOPAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CANNULA; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; DENERVATION; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; DOPAMINE METABOLISM; DOPAMINERGIC ACTIVITY; IMAGING SOFTWARE; INTERMETHOD COMPARISON; MALE; METABOLITE; MICRODIALYSIS; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 84887266989     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/2191-219X-3-69     Document Type: Article

References (40)

1. Garnett ES, Firnau G, Nahmias C: Dopamine visualized in the basal ganglia of living man. Nature 1983, 305:137-138.
2. Gjedde A, Reith J, Dyve S, Leger G, Guttman M, Diksic M, Evans A, Kuwabara H: Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci USA 1991, 88:2721-2725.
3. Kumakura Y, Cumming P: PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches. Neuroscientist 2009, 15:635-650.
4. Martin WRW, Palmer MR, Patlak CS, Calne DB: Nigrostriatal function in humans studied with positron emission tomography. Ann Neurol 1989, 26:535-542.
5. Holden JE, Doudet D, Endres CJ, Chan GLY, Morrison KS, Vingerhoets FJG, Snow BJ, Pate BD, Sossi V, Buckley KR, Ruth TJ: Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase. J Nucl Med 1997, 38:1568-1574.
6. Sossi V, Doudet DJ, Holden JE: A reversible tracer analysis approach to the study of effective dopamine turnover. J Cereb Blood Flow Metab 2001, 21:469-476.
7. Sharma SK, Ebadi M: Distribution kinetics of F-18-DOPA in weaver mutant mice. Mol Brain Res 2005, 139:23-30.
8. Sharma SK, El-ReFaey H, Ebadi M: Complex-1 activity and F-18-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q(10). Brain Res Bull 2006, 70:22-32.
9. Kyono K, Takashima T, Katayama Y, Kawasaki T, Zochi R, Gouda M, Kuwahara Y, Takahashi K, Wada Y, Onoe H, Watanabe Y: Use of [18F]FDOPA-PET for in vivo evaluation of dopaminergic dysfunction in unilaterally 6-OHDA-lesioned rats. EJNMMI Res 2011, 1:25.
10. Walker MD, Dinelle K, Kornelsen R, McCormick S, Mah C, Holden JE, Farrer MJ, Stoessl AJ, Sossi V: In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [18F]FDOPA PET. J Cereb Blood Flow Metab 2013, 33:59-66.
11. Masuo Y, Pelaprat D, Scherman D, Rostene W: [H-3]Dihydrotetrabenazine, a new marker for the visualization of dopaminergic denervation in the rat striatum. Neurosci Lett 1990, 114:45-50.
12. Sossi V, Holden JE, Topping GJ, Camborde ML, Kornelsen RA, McCormick SE, Greene J, Studenov AR, Ruth TJ, Doudet DJ: In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD. J Cereb Blood Flow Metab 2007, 27:1407-1415.
13. Benveniste H: Brain microdialysis. J Neurochem 1989, 52:1667-1679.
14. Darvesh AS, Carroll RT, Geldenhuys WJ, Gudelsky GA, Klein J, Meshul CK, Van der-Schyf CJ: In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery. Expert Opin Drug Discov 2011, 6:109-127.
15. Ungerstedt U: Microdialysis-principles and applications for studies in animals and man. J Intern Med 1991, 230:365-373.
16. Del-Amo EM, Urtti A, Yliperttula M: Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 2008, 35:161-174.
17. Deep P, Gjedde A, Cumming P: On the accuracy of an [18F]FDOPA compartmental model: evidence for vesicular storage of [18F] fluorodopamine in vivo. J Neurosci Methods 1997, 76:157-165.
18. Peter D, Liu Y, Sternini C, De-Giorgio R, Brecha N, Edwards RH: Differential expression of two vesicular monoamine transporters. J Neurosci 1995, 15:6179-6188.
19. Okada M, Nakao R, Hosoi R, Zhang MR, Fukumura T, Suzuki K, Inoue O: Microdialysis with radiometric monitoring of L-[beta-(11)C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate. J Cereb Blood Flow Metab 2011, 31:124-131.
20. Westerink BH: Sequence and significance of dopamine metabolism in the rat brain. Neurochem Int 1985, 7:221-227.
21. Ungerstedt U: 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 1968, 5:107-110.
22. Schwarting RKW, Huston JP: Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae. Prog Neurobiol 1996, 49:215-266.
23. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. San Diego: Academic; 1997.
24. Kelly PH, Iversen SD: Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor-activity in rats. Eur J Pharmacol 1976, 40:45-56.
25. Kim JS, Lee JS, Im KC, Kim SJ, Kim SY, Lee DS, Moon DH: Performance measurement of the microPET focus 120 scanner. J Nucl Med 2007, 48:1527-1535.
26. McLellan CA, Doudet DJ, Brucke T, Aigner TG, Cohen RM: New rapid analysis method demonstrates differences in 6-(F-18)fluoro-L-dopa plasma input curves with and without carbidopa and in hemi-MPTP lesioned monkeys. Appl Radiat Isot 1991, 42:847-854.
27. Rubins DJ, Melega WP, Lacan G, Way B, Plenevaux A, Luxen A, Cherry SR: Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain. Neuroimage 2003, 20:2100-2118.
28. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL: Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 1996, 16:834-840.
29. Topping GJ, Dinelle K, Kornelsen R, McCormick S, Holden JE, Sossi V: Positron emission tomography kinetic modeling algorithms for small animal dopaminergic system imaging. Synapse 2010, 64:200-208.
30. Patlak CS, Blasberg RG: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 1985, 5:584-590.
31. Levin JR, Serlin RC, Seaman MA: A controlled, powerful multiple-comparison strategy for several situations. Psychol Bull 1994, 115:153-159.
32. Robinson TE, Whishaw IQ: Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats. Brain Res 1988, 450:209-224.
33. Hume SP, Opacka-Juffry J, Myers R, Ahier RG, Ashworth S, Brooks DJ, Lammertsma AA: Effect of L-dopa and 6-hydroxydopamine lesioning on [11C]raclopride binding in rat striatum, quantified using PET. Synapse 1995, 21:45-53.
34. Tsukada H, Lindner KJ, Hartvig P, Tani Y, Bjurling P, Kihlberg T, Westerberg G, Watanabe Y, Langstrom B: Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[beta-11C]dopa turnover in the rat striatum with infusion of L-tyrosine. J Neural Transm Gen Sect 1994, 95:1-15.
35. Curran EJ, Albin RL, Becker JB: Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre-and postsynaptic dopamine function. J Neurosci 1993, 13:3864-3877.
36. Douglas R, Kellaway L, Mintz M, Van-Wageningen G: The crossed nigrostriatal projection decussates in the ventral tegmental decussation. Brain Res 1987, 418:111-121.
37. Gonzalez-Hernandez T, Barroso-Chinea P, Rodriguez M: Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the rat. Mov Disord 2004, 19:1029-1042.
38. Breit S, Martin A, Lessmann L, Cerkez D, Gasser T, Schulz JB: Bilateral changes in neuronal activity of the basal ganglia in the unilateral 6-hydroxydopamine rat model. J Neurosci Res 2008, 86:1388-1396.
39. Schwarting RK, Huston JP: The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol 1996, 50:275-331.
40. Dinelle K, Walker MD, McCormick S, Kornelsen R, Sossi V: Age related changes in the dopaminergic system of the Sprague-Dawley rat measured via positron emission tomography [abstract]. J Nucl Med 2013, 54(Suppl 2):249.