Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms-comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review)"

Gynecological Endocrinology

Volumn 29, Issue 12, 2013, Pages 1022-1025

  Beer, André M ^a   Osmers, Rüdiger ^b   Schnitker, Jörg ^c   Bai, Wenpei ^d   Mueck, Alfred O ^e   Meden, Harald ^f  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c Institute for Applied Statistics Dr   (Germany)

^d PEKING UNIVERSITY FIRST HOSPITAL   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f Paracelsus Spital Richterswil   (Switzerland)

Author keywords

Actaea Cimicifuga racemosa; Benefit risk ratio; Black cohosh; Clinical studies; Cochrane report; Menopausal symptoms

Indexed keywords

CIMICIFUGA RACEMOSA EXTRACT; PLACEBO;

CLINICAL STUDY; DRUG EFFICACY; DRUG INDICATION; DRUG QUALITY; DRUG SAFETY; HUMAN; MENOPAUSAL SYNDROME; PRIORITY JOURNAL; REVIEW; RHIZOME; TREATMENT DURATION;

CIMICIFUGA; CONTROLLED CLINICAL TRIALS AS TOPIC; EVIDENCE-BASED MEDICINE; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RISK ASSESSMENT;

EID: 84887240426     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2013.831836     Document Type: Review

References (28)

1. European Medicines Agency: Community Herbal Monograph on Cimicifuga racemosa (L). Nutt., rhizoma. Available from: http://www.ema.europa.eu/docs/en- GB/document-library/Herbal-Community-herbal-monograph/2011/01/WC500100981.pdf [last accessed 14 Mar 2013].
2. European Medicines Agency: Assessment Report on Cimicifuga racemosa (L.) Nutt., rhizoma. Available from: http://www.ema. europa.eu/docs/en-GB/document- library/Herbal-HMPC-assess ment-report/2011/05/WC500106358.pdf [last accessed 14 Mar 2013].
3. European Scientific Cooperative on Phytotherapy. Monographs: Cimicifugae rhizoma Black Cohosh. ESCOP 2011, pp 24.
4. Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms Cochrane Database Syst. Reviews 2012;9:CD007244.
5. Amsterdam JD, Yao Y, Mao JJ, et al. Randomised, double-blind, placebo-controlled trial of Cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause. J Clin Psychopharmacol 2009;29:478-83.
6. Bai W, Henneicke-von Zepelin HH, Wang S, et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas 2007;58:31-41.
7. Bebenek M, Kemmler W, von Stengel S, et al. Effect of exercise and Cimicifuga racemosa (CR BNO 1055) on bone mineral density, 10-year coronary heart disease risk, and menopausal complaints: the randomized controlled Training and Cimicifuga racemosa Erlangen (TRACE) study. Menopause 2010; 17:791-800.
8. Carlisle A, Jessup JV. Effect of black cohosh on biochemical markers of bone remodeling in postmenopausal women [dissertation]. Florida: University of Florida; 2008.
9. Frei-Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas 2005;51: 397-404.
10. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomised controlled trial. Menopause 2009;16: 1156-66.
11. Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001;19:2739-45.
12. Kronenberg F, Warren M, Coleton M, et al. Effect of black cohosh extract on hot flashes and other menopausal symptoms. Poster presentation, 20th Annual Meeting, North American Menopause Society, San Diego, CA; 2009.
13. Lehmann-Willenbrock WE, Riedel HH. Clinical and endocrinologic examinations about therapy of climacteric symptoms following hysterectomy with remaining ovaries [Klinische und endokrinologische Untersuchungen zur Therapie ovarieller Ausfallserscheinungen nach Hysterektomie unter Belassung der Adnexe]. Zentralblat Gynäkol 1988;110:611-8.
14. Nappi RE, Malavasi B, Brundu B, Facchinetti F. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005;20: 30-5.
15. Newton KM, Reed SD, LaCroix AZ, et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Internal Med 2006;145:869-79.
16. Oktem M, Eroglu D, Karahan HB, et al. Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther 2007;24:448-61.
17. Osmers R, Friede M, Liske E, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol 2005;105:1074-83.
18. Pockaj BA, Gallagher JG, Loprinzi CL, et al. Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol 2006;24:2836-41.
19. Stoll W. Phytopharmacon influences atrophic vaginal epithelium: double blind study: cimicifuga versus estrogenic substances [Phytotherapeutikum beeinflubt atrophisches Vaginalepithel: Doppelblindversuch Cimicifuga versus Ö strogenpraparat]. Therapeutikum 1987;1:23-31.
20. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 versus conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003;44:S67-77.
21. Kaiser W, Martin R, Schellenberg R, et al. Cimicifuga racemosa Extrakt Ze 450 bei Wechseljahrbeschwerden: Eine pflanzliche, nichthormonale Alternative. Ars Medici 2008;17: 771-4.
22. Li Y, Cui M, Gao S. Efficacy of Remifemin for control of climacteric symptoms. (Article in Chinese) Progr Obstet Gynecol 2011;20:462-5.
23. American Botanical Council. Black cohosh clinical trial not representative of previous research showing positive results. Austin, TX, 21 December 2006. HerbalEGram, Vol 4. Available from: http://cms.herbalgram.org/ heg/volume4/page47.html [last accessed 14 Mar 2013].
24. Newton KM, Reed SD, Grothaus L, et al. Reprint of The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas 2008;61:181-93; first published in: Maturitas 2005;52:134-46.
25. Oliff H S. Cochrane review finds insufficient evidence to support black cohosh efficacy for menopausal symptoms. American Botanical Council HerbClip HC 101252-466, 15 Feb 2013.
26. Monograph Black cohosh root/Cimicifugawurzelstock. German Commission E, Germany: Bundesanzeiger; 2 Mär 1989.
27. Gagnier JJ, Boon H, for the CONSORT Group, et al. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med 2006;144:364-7.
28. Letters, comments and responses. Alternative treatments of vasomotor symptoms of menopause. Ann Internal Med 2007;147:346-7.