Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior

Metabolic Brain Disease

Volumn 28, Issue 4, 2013, Pages 563-570

  Wayhs, Carlos Alberto Yasin ^a,b   Mescka, Caroline Paula ^a,b   Vanzin, Camila Simioni ^a,b   Ribas, Graziela Schmitt ^b   Guerreiro, Gilian ^a,b   Nin, Maurício Schüler ^c   Manfredini, Vanusa ^d   Barros, Helena Maria Tannhauser ^c   Vargas, Carmen Regla ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^d UNIPAMPA   (Brazil)

Author keywords

Brain; Comet assay; Depression; Diabetes; Lipid damage; Oxidative stress

Indexed keywords

CLONAZEPAM; DNA; GLUCOSE; HUMAN INSULIN; INSULIN; LIPID; MALONALDEHYDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; DNA DAMAGE; DRUG BRAIN LEVEL; DRUG EFFECT; FORCED SWIMMING TEST; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; HIPPOCAMPUS; IN VIVO STUDY; INSULIN TREATMENT; LIPID BRAIN LEVEL; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; PREFRONTAL CORTEX; RAT; STREPTOZOCIN DIABETES;

ANIMALIA; RATTUS;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CLONAZEPAM; DEPRESSION; DIABETES MELLITUS, EXPERIMENTAL; DNA DAMAGE; GABA MODULATORS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84887217832     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-013-9397-z     Document Type: Article

References (49)

1. Barber M, Kasturi BS, Austin ME, Patel KP, MohanKumar SM, MohanKumar PS (2003) Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin. Brain Res 964(1):128-135
2. Bhatia S, Shukla R, Venkata Madhu S, Kaur Gambhir J, Madhava Prabhu K (2003) Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem 36(7):557-562
3. Biessels GJ, Gispen WH (2005) The impact of diabetes on cognition: what can be learned from rodent models? Neurobiol Aging 26(Suppl 1):36-41. doi: 10.1016/j.neurobiolaging.2005.08.015
4. Blasi C, Jeanrenaud B (1993) Insulin resistance syndrome: defective GABA neuromodulation as a possible hereditary pathogenetic factor (the 'GABA hypothesis'). Med Hypotheses 40(4):197-206
5. Bouwman V, Adriaanse MC, Van 't Riet E, Snoek FJ, Dekker JM, Nijpels G (2010) Depression, anxiety and glucose metabolism in the general dutch population: the new Hoorn study. PLoS One 5(4):e9971. doi: 10.1371/journal.pone. 0009971
6. Brands AM, Biessels GJ, de Haan EH, Kappelle LJ, Kessels RP (2005) The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care 28(3):726-735
7. Ceretta LB, Reus GZ, Stringari RB, Ribeiro KF, Zappellini G, Aguiar BW, Pfaffenseller B, Lersh C, Kapczinski F, Quevedo J (2012) Imipramine treatment reverses depressive-like behavior in alloxan-diabetic rats. Diabetes Metab Res Rev 28(2):139-144
8. Ceriello A (2003) New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care 26(5):1589-1596
9. da Silva Haeser A, Sitta A, Barschak AG, Deon M, Barden AT, Schmitt GO, Landgraff S, Gomez R, Barros HM, Vargas CR (2007) Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. Brain Res 1154:137-143. doi: 10.1016/j.brainres.2007.03.088
10. Esterbauer H (1993) Cytotoxicity and genotoxicity of lipid-oxidation products. Am J Clin Nutr 57(5 Suppl):779S-785S, discussion 785S-786S
11. Figlewicz DP, Szot P (1991) Insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha 1-adrenergic activity in the rat hippocampus. Brain Res 550(1):101-107
12. Figlewicz DP, Ikeda H, Hunt TR, Stein LJ, Dorsa DM, Woods SC, Porte D Jr (1986) Brain insulin binding is decreased in Wistar Kyoto rats carrying the 'fa' gene. Peptides 7(1):61-65
13. Gomez R, Barros HM (2000) Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats. Pharmacol Biochem Behav 66(2):329-335
14. Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ, Safren SA (2008) Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31(12):2398-2403. doi: 10.2337/dc08-1341
15. Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, Collins A, Smith A, Speit G, Thybaud V, Tice RR (2003) Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop. Mutagenesis 18(1):45-51
16. Hilakivi-Clarke LA, Wozniak KM, Durcan MJ, Linnoila M (1990) Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression. Physiol Behav 48(3):429-433
17. Holmes CS, Richman LC (1985) Cognitive profiles of children with insulin-dependent diabetes. J Dev Behav Pediatr 6(6):323-326
18. Karatepe M (2004) Simultaneous determination of ascorbic acid and free malondialdehyde in human serum by HPLC-UV. LCGC North Am 22(5):362-365
19. Kocic R, Pavlovic D, Kocic G (2007) Impact of intensive insulin treatment on the development and consequences of oxidative stress in insulin-dependent diabetes mellitus. Vojnosanit Pregl 64(9):623-628
20. Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM (2006) Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am J Physiol Heart Circ Physiol 290(5):H1777-H1787. doi: 10.1152/ajpheart.01087.2005
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265-275
22. Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE (2000) Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23(7):934-942
23. Manfredini V, Biancini GB, Vanzin CS, Dal Vesco AM, Cipriani F, Biasi L, Tremea R, Deon M, Peralba Mdo C, Wajner M, Vargas CR (2010) Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients. Cell Biochem Funct 28(5):360-366. doi: 10.1002/cbf.1654
24. Marks JL, Maddison J, Eastman CJ (1988) Subcellular localization of rat brain insulin binding sites. J Neurochem 50(3):774-781
25. Matsumoto H, Rhoads DE (1990) Specific binding of insulin to membranes from dendrodendritic synaptosomes of rat olfactory bulb. J Neurochem 54(1):347-350
26. Mijnhout GS, Scheltens P, Diamant M, Biessels GJ, Wessels AM, Simsek S, Snoek FJ, Heine RJ (2006) Diabetic encephalopathy: a concept in need of a definition. Diabetologia 49(6):1447-1448. doi: 10.1007/s00125-006-0221-8
27. Morishita S (2009) Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review. Hum Psychopharmacol 24(3):191-198. doi: 10.1002/hup.1015
28. Nadin SB, Vargas-Roig LM, Ciocca DR (2001) A silver staining method for single-cell gel assay. J Histochem Cytochem 49(9):1183-1186
29. Naudi A, Jove M, Ayala V, Cassanye A, Serrano J, Gonzalo H, Boada J, Prat J, Portero-Otin M, Pamplona R (2012) Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress. Exp Diabetes Res 2012:696215. doi: 10.1155/2012/696215
30. Pan HZ, Zhang H, Chang D, Li H, Sui H (2008) The change of oxidative stress products in diabetes mellitus and diabetic retinopathy. Br J Ophthalmol 92(4):548-551. doi: 10.1136/bjo.2007.130542
31. Ramanathan M, Jaiswal AK, Bhattacharya SK (1998) Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology (Berl) 135(4):361-367
32. Robles GI, Singh-Franco D (2009) A review of exenatide as adjunctive therapy in patients with type 2 diabetes. Drug Des Dev Ther 3:219-240
33. Rudolph U, Mohler H (2006) GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol 6(1):18-23. doi: 10.1016/j.coph.2005.10.003
34. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr (1992) Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13(3):387-414
35. Sima AA, Kamiya H, Li ZG (2004) Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes. Eur J Pharmacol 490(1-3):187-197. doi: 10.1016/j.ejphar.2004.02.056
36. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175(1):184-191
37. Speit G, Hartmann A (1995) The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). Mutagenesis 10(6):555-559
38. Styskal J, Van Remmen H, Richardson A, Salmon AB (2012) Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med 52(1):46-58. doi: 10.1016/j.freeradbiomed. 2011.10.441
39. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35(3):206-221
40. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44-84. doi: 10.1016/j.biocel.2006.07.001
41. Wan Q, Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF, Wang YT (1997) Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature 388(6643):686-690. doi: 10.1038/41792
42. Wayhs CA, Manfredini V, Sitta A, Deon M, Ribas G, Vanzin C, Biancini G, Ferri M, Nin M, Barros HM, Vargas CR (2010a) Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect. Metab Brain Dis 25(3):297-304. doi: 10.1007/s11011-010-9211-0
43. Wayhs CA, Manfredini V, Sitta A, Deon M, Ribas GS, Vanzin CS, Biancini GB, Nin MS, Barros HM, Vargas CR (2010b) Effects of insulin and clonazepam on DNA damage in diabetic rats submitted to the forced swimming test. Mutat Res 703(2):187-190. doi: 10.1016/j.mrgentox.2010.08.017
44. Wei LT, Matsumoto H, Rhoads DE (1990) Release of immunoreactive insulin from rat brain synaptosomes under depolarizing conditions. J Neurochem 54(5):1661-1665
45. Wiernsperger NF (2003) Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab 29(6):579-585
46. Wilcox BJ, Corp ES, Dorsa DM, Figlewicz DP, Greenwood MR, Woods SC, Baskin DG (1989) Insulin binding in the hypothalamus of lean and genetically obese Zucker rats. Peptides 10(6):1159-1164
47. Young IS, Woodside JV (2001) Antioxidants in health and disease. J Clin Pathol 54(3):176-186
48. Zhao WQ, Alkon DL (2001) Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177(1-2):125-134
49. Zhao W, Chen H, Xu H, Moore E, Meiri N, Quon MJ, Alkon DL (1999) Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 274(49):34893-34902