The substitute brain and the potential of the gel model

Annals of Neurosciences

Volumn 20, Issue 3, 2013, Pages 118-122

  Pomfret, Roland ^a   Miranpuri, Gurwattan ^a   Sillay, Karl ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Agarose gel; Brain infusion; Catheter; History; In vitro model; Overview; Protocol

Indexed keywords

AGAROSE; LIPOPROTEIN;

CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CONCENTRATION RESPONSE; ELASTICITY; ELECTROPHORESIS; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; POROSITY; PRESSURE; PROTEIN ISOLATION; PURIFICATION; REVIEW; VALIDITY;

EID: 84887199765     PISSN: 09727531     EISSN: 09763260     Source Type: Journal    
DOI: 10.5214/ans.0972.7531.200309     Document Type: Review

References (20)

1. Chen ZJ, Gillies GT, Broaddus WC, et al. A realistic brain tissue phantom for intra-parenchymal infusion studies. Journal of Neurosurgery. 2004; 101(2): 314-22.
2. Chen ZJ, Broaddus WC, Viswanathan RR, et al. Intraparenchymal drug delivery via positive-pressure infusion: Experimental and modeling studies of poroelasticity in brain phantom gels. Ieee Transactions on Bio-medical Engineering. 2002; 49(2): 85-96.
3. Raghavan R, Mikaelian S, Brady M et al. Fluid infusions from catheters into elastic tissue: I. Azimuthally symmetric back-flow in homogeneous media. Physics in Medicine and Biology. 2010; 55(1): 281-304.
4. Margolis S. Separation and size determination of human serum lipoproteins by agarose gel filtration. Journal of Lipid Research. 1967; 8(5): 501.
5. Arlinghaus RB, Kaczmarczyk W, Polatnick J. Electrophoretic characterization of foot-and-mouth disease virus-specific ribo-nucleic acid. J Virol. 1969; 4(5): 712-8.
6. Fujii T, Yano T, Kumagai H, et al. Scaling analysis of the concentration dependence on elasticity of agarose gel. Bioscience Biotechnology and Biochemistry. 2000; 64(8): 1618-1622.
7. Jilla YD, Gillies GT, Broaddus WC, et al. Univ. Virginia Sch. Eng. Appl. Sci., Charlottes-ville, Tech. Rep. UVA/640 419/MANE99/103, 1999.
8. Chen ZJ, Fillmore HL, Prabhu SS, et al. Univ. Virginia Sch. Eng. Appl. Sci., Charlottes-ville, Tech. Rep. UVA/640 419/MAE00/104, 2000.
9. Ahmed AJ, Gillies GT, Broaddus WC, et al. Catheter drag force measurements using a gel model of the brain. Univ. Virginia Sch. Eng. Appl. Sci., Charlottesville, Tech. Rep. UVA/640 419/MAE00/102, 2000.
10. Howard MA, Abkes BA, Ollendieck MC, et al. Measurement of the force required to move a neurosurgical probe through in vivo human brain tissue. Ieee Transactions on Biomedical Engineering. 1999; 46(7):891-894.
11. Gillies GT, Allison SW, Tissue BM. Positive pressure infusion of fluorescent n anoparticles as a probe of the structure of brain phantom gelatins. Nanotechnology. 2002; 13(4): 484-6.
12. Gillies GT, Wilhelm TD, Humphrey JAC, et al. A spinal cord surrogate with nanoscale porosity for in vitro simulations of restorative neurosurgical techniques. Nano-technology. 2002; 13(5): 587-91.
13. Prabhu SS, Broaddus WC, Gillies GT, et al. Distribution of macromolecular dyes in brain using positive pressure infusion: A model for direct controlled delivery of therapeutic agents. Surgical Neurology. 1998; 50(4): 367-75.
14. Sillay K, Schomberg D, Hinchman A, et al. Benchmarking the ERG valve tip and MRI Interventions Smart Flow neurocatheter convection-enhanced delivery system's performance in a gel model of the brain: employing infusion protocols proposed for gene therapy for Parkinson's disease. Journal of Neural Engineering. 2012; 9(2): 026009.
15. White E, Bienemann A, Malone J, et al. An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery. Journal of Neuroscience Methods. 2011; 199(1): 87-97.
16. Casanova F, Carney PR, Sarntinoranont M. Influence of Needle Insertion Speed on Backflow for Convection-Enhanced Delivery. Journal of Biomechanical Engineering-Transactions of the Asme. 2012; 134(4): 8.
17. Sindhwani N, Ivanchenko O, Lueshen E, et al. Methods for Determining Agent Concentration Profiles in Agarose Gel During Convection-Enhanced Delivery. Ieee Transactions on Biomedical Engineering. 2011; 58(3): 626-32.
18. Linninger AA, Somayaji MR, Mekarski M, et al. Prediction of convection-enhanced drug delivery to the human brain. Journal of Theoretical Biology. 2008; 250(1): 125-38.
19. Linninger AA, Somayaji MR, Zhang LB, et al. Rigorous mathematical modeling techniques for optimal delivery of macro-molecules to the brain. Ieee Transactions on Biomedical Engineering. 2008; 55(9): 2303-13.
20. Yin D, Forsayeth J, Bankiewicz KS. Optimized cannula design and placement for convection-enhanced delivery in rat stria-tum. Journal of Neuroscience Methods. 2010; 187(1): 46-51.