Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms

Microcirculation

Volumn 20, Issue 8, 2013, Pages 736-747

  Tu, Lei ^a   Pan, Chun Shui ^a,b   Wei, Xiao Hong ^a   Yan, Li ^a,b   Liu, Yu Ying ^a,b   Fan, Jing Yu ^b   Mu, Hong Na ^a   Li, Quan ^a,b   Li, Lin ^a   Zhang, Yu ^a   He, Ke ^a   Mao, Xiao Wei ^a   Sun, Kai ^a,b   Wang, Chuan She ^a,b   Yin, Chang Cheng ^a   Han, Jing Yan ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b State Administration of Traditional Chinese Medicine of the People's Republic of China   (China)

Author keywords

ATP 5D; Cardiac function; Energy metabolism; Myocardial structure

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ASTRAGALOSIDE IV; F ACTIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ENERGY; ENERGY METABOLISM; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; IMMUNOFLUORESCENCE; ISCHEMIA; MALE; MODULATION; MOLECULE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REPERFUSION INJURY; STAINING;

ATP 5D; CARDIAC FUNCTION; ENERGY METABOLISM; MYOCARDIAL STRUCTURE;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PROTON-TRANSLOCATING ATPASES; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; TRITERPENES; TROPONIN I;

EID: 84887175318     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/micc.12074     Document Type: Article

References (22)

1. Boden WE, O'Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G, Blaustein AS, Booth DC, Bates ER, Spertus JA, Berman DS, Mancini GB, Weintraub WS, Group CTR. Optimal medical therapy with or without pci for stable coronary disease. N Engl J Med 356: 1503-1516, 2007.
2. Falahati A, Sharkey SW, Christensen D, McCoy M, Miller EA, Murakami MA, Apple FS. Implementation of serum cardiac troponin I as marker for detection of acute myocardial infarction. Am Heart J 137: 332, 1999.
3. Frohlich GM, Meier P, White SK, Yellon DM, Hausenloy DJ. Myocardial reperfusion injury: looking beyond primary pci. Eur Heart J 34: 1714-1722, 2013.
4. Gaballo A, Zanotti F, Papa S. Structures and interactions of proteins involved in the coupling function of the protonmotive F(o)F(1)-ATP synthase. Curr Protein Pept Sci 3: 451-460, 2002.
5. Gui D, Huang J, Guo Y, Chen J, Chen Y, Xiao W, Liu X, Wang N. Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression. Cytokine 61: 970-977, 2013.
6. Gui D, Huang J, Liu W, Guo Y, Xiao W, Wang N. Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways. Apoptosis 18: 409-422, 2013.
7. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 123: 92-100, 2013.
8. 2+, atp, and compartmentation. Circ Res 49: 1119-1128, 1981.
9. Huang C, Wang G, Li H, Xie H, Sun J, Lv H, Lv T. Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma. J Pharm Biomed Anal 40: 788-793, 2006.
10. Korn ED, Carlier MF, Pantaloni D. Actin polymerization and atp hydrolysis. Science 238: 638-644, 1987.
11. Lin SQ, Wei XH, Huang P, Liu YY, Zhao N, Li Q, Pan CS, Hu BH, Chang X, Fan JY, Yang XY, Wang CS, Liu HN, Han JY. Qishenyiqi pills(r) prevents cardiac ischemia-reperfusion injury via energy modulation. Int J Cardiol, pii: S0167-5273(12)01417-9, 2012.
12. Mathers C, Stevens G, Mascarenhas M. Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks. Geneve, Switzerland: World Health Organization, 2009.
13. Ola MS, Nawaz M, Ahsan H. Role of bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351: 41-58, 2011.
14. Piper HM. Energy deficiency, calcium overload or oxidative stress: possible causes of irreversible ischemic myocardial injury. Klin Wochenschr 67: 465-476, 1989.
15. Steenbergen C, Murphy E, Watts JA, London RE. Correlation between cytosolic free calcium, contracture, atp, and irreversible ischemic injury in perfused rat heart. Circ Res 66: 135-146, 1990.
16. 2+-activated force in mechanically skinned skeletal muscle fibres of the rat. Pflügers Archiv 424: 30-38, 1993.
17. Wei XH, Liu YY, Li Q, Yan L, Hu BH, Pan CS, Li ZX, Chang X, Fan JY, Zhao N, Sun K, Huang P, Wang CS, Fan TP, Han JY. Treatment with cardiotonic pills((r)) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation 20: 17-29, 2013.
18. Wen X-D, Qi L-W, Li P, Bao K-D, Yan X-W, Yi L, Li C-Y. Simultaneous determination of calycosin-7-o-β-d-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of danggui buxue tang extract for their pharmacokinetic studies by liquid chromatography-mass spectrometry. J Chromatogr B 865: 99-105, 2008.
19. Wheaton WW, Chandel NS. Hypoxia. 2. Hypoxia regulates cellular metabolism. Am J Physiol Cell Physiol 300: C385-393, 2011.
20. Yin Y, Guan Y, Duan J, Wei G, Zhu Y, Quan W, Guo C, Zhou D, Wang Y, Xi M, Wen A. Cardioprotective effect of danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of h9c2 cardiomyocytes via akt and erk1/2 phosphorylation. Eur J Pharmacol 699: 219-226, 2013.
21. Zhang ZG, Wu L, Wang JL, Yang JD, Zhang J, Li LH, Xia Y, Yao LB, Qin HZ, Gao GD. Astragaloside iv prevents mpp(+)-induced sh-sy5y cell death via the inhibition of bax-mediated pathways and ros production. Mol Cell Biochem 364: 209-216, 2012.
22. Zhao N, Liu YY, Wang F, Hu BH, Sun K, Chang X, Pan CS, Fan JY, Wei XH, Li X, Wang CS, Guo ZX, Han JY. Cardiotonic pills, a compound chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol 298: H1166-1176, 2010.