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Volumn 4, Issue 5, 2013, Pages

Proton-dependent gating and proton uptake by Wzx support o-antigen-subunit Antiport across the bacterial inner membrane

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; LIPOOLIGOSACCHARIDE; O ANTIGEN; PROTEOLIPOSOME; PROTON; SODIUM ION; UNCLASSIFIED DRUG; WZX PROTEIN;

EID: 84887168855     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00678-13     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 0033847562 scopus 로고    scopus 로고
    • Establishment of Pseudomonas aeruginosa infection: Lessons from a versatile opportunist
    • Lyczak JB, Cannon CL, Pier GB. 2000. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect. 2:1051-1060.
    • (2000) Microbes Infect , vol.2 , pp. 1051-1060
    • Lyczak, J.B.1    Cannon, C.L.2    Pier, G.B.3
  • 2
    • 84865173458 scopus 로고    scopus 로고
    • Genetic and functional diversity of Pseudomonas aeruginosa lipopolysaccharide
    • Lam JS, Taylor VL, Islam ST, Hao Y, Kocíncová D. 2011. Genetic and functional diversity of Pseudomonas aeruginosa lipopolysaccharide. Front. Microbiol. 2:1-25.
    • (2011) Front. Microbiol , vol.2 , pp. 1-25
    • Lam, J.S.1    Taylor, V.L.2    Islam, S.T.3    Hao, Y.4    Kocíncová, D.5
  • 3
    • 84875910878 scopus 로고    scopus 로고
    • Wzx flippase-mediated membrane translocation of sugar polymer precursors in bacteria
    • Islam ST, Lam JS. 2013. Wzx flippase-mediated membrane translocation of sugar polymer precursors in bacteria. Environ. Microbiol. 15: 1001-1015.
    • (2013) Environ. Microbiol , vol.15 , pp. 1001-1015
    • Islam, S.T.1    Lam, J.S.2
  • 4
    • 79952152673 scopus 로고    scopus 로고
    • Membrane topology mapping of the O-antigen flippase (Wzx), polymerase (Wzy), and ligase (WaaL) from Pseudomonas aeruginosa PAO1 reveals novel domain architectures
    • doi:10.1128/mBio.00189-10
    • Islam ST, Taylor VL, Qi M, Lam JS. 2010. Membrane topology mapping of the O-antigen flippase (Wzx), polymerase (Wzy), and ligase (WaaL) from Pseudomonas aeruginosa PAO1 reveals novel domain architectures. mBio 1(3):e00189-10. doi:10.1128/mBio.00189-10.
    • (2010) MBio , vol.1 , Issue.3
    • Islam, S.T.1    Taylor, V.L.2    Qi, M.3    Lam, J.S.4
  • 5
    • 0032917464 scopus 로고    scopus 로고
    • Effect of wzx (rfbX) mutations on A-band and B-band lipopolysaccharide biosynthesis in Pseudomonas aeruginosa O5
    • Burrows LL, Lam JS. 1999. Effect of wzx (rfbX) mutations on A-band and B-band lipopolysaccharide biosynthesis in Pseudomonas aeruginosa O5. J. Bacteriol. 181:973-980.
    • (1999) J. Bacteriol , vol.181 , pp. 973-980
    • Burrows, L.L.1    Lam, J.S.2
  • 6
    • 84865157678 scopus 로고    scopus 로고
    • A cationic lumen in the Wzx flippase mediates anionic O-antigen subunit translocation in Pseudomonas aeruginosa PAO1
    • Islam ST, Fieldhouse RJ, Anderson EM, Taylor VL, Keates RA, Ford RC, Lam JS. 2012. A cationic lumen in the Wzx flippase mediates anionic O-antigen subunit translocation in Pseudomonas aeruginosa PAO1. Mol. Microbiol. 84:1165-1176.
    • (2012) Mol. Microbiol , vol.84 , pp. 1165-1176
    • Islam, S.T.1    Fieldhouse, R.J.2    Anderson, E.M.3    Taylor, V.L.4    Keates, R.A.5    Ford, R.C.6    Lam, J.S.7
  • 7
    • 0029998771 scopus 로고    scopus 로고
    • An O-antigen processing function for Wzx (RfbX): A promising candidate for O-unit flippase
    • Liu D, Cole RA, Reeves PR. 1996. An O-antigen processing function for Wzx (RfbX): a promising candidate for O-unit flippase. J. Bacteriol. 178: 2102-2107.
    • (1996) J. Bacteriol , vol.178 , pp. 2102-2107
    • Liu, D.1    Cole, R.A.2    Reeves, P.R.3
  • 8
    • 0029037440 scopus 로고
    • Molecular cloning and characterization of the rfc gene of Pseudomonas aeruginosa (serotype O5)
    • de Kievit TR, Dasgupta T, Schweizer H, Lam JS. 1995. Molecular cloning and characterization of the rfc gene of Pseudomonas aeruginosa (serotype O5). Mol. Microbiol. 16:565-574.
    • (1995) Mol. Microbiol , vol.16 , pp. 565-574
    • de Kievit, T.R.1    Dasgupta, T.2    Schweizer, H.3    Lam, J.S.4
  • 9
    • 79957993746 scopus 로고    scopus 로고
    • Dual conserved periplasmic loops possess essential charge characteristics that support a catch-and-release mechanism of O-antigen polymerization by Wzy in Pseudomonas aeruginosa PAO1
    • Islam ST, Gold AC, Taylor VL, Anderson EM, Ford RC, Lam JS. 2011. Dual conserved periplasmic loops possess essential charge characteristics that support a catch-and-release mechanism of O-antigen polymerization by Wzy in Pseudomonas aeruginosa PAO1. J. Biol. Chem. 286: 20600-20605.
    • (2011) J. Biol. Chem , vol.286 , pp. 20600-20605
    • Islam, S.T.1    Gold, A.C.2    Taylor, V.L.3    Anderson, E.M.4    Ford, R.C.5    Lam, J.S.6
  • 11
    • 0031038569 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa B-band O-antigen chain length is modulated by Wzz (Ro1)
    • Burrows LL, Chow D, Lam JS. 1997. Pseudomonas aeruginosa B-band O-antigen chain length is modulated by Wzz (Ro1). J. Bacteriol. 179: 1482-1489.
    • (1997) J. Bacteriol , vol.179 , pp. 1482-1489
    • Burrows, L.L.1    Chow, D.2    Lam, J.S.3
  • 12
    • 0036942209 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa O-antigen chain length is determined before ligation to lipid A core
    • Daniels C, Griffiths C, Cowles B, Lam JS. 2002. Pseudomonas aeruginosa O-antigen chain length is determined before ligation to lipid A core. Environ. Microbiol. 4:883-897.
    • (2002) Environ. Microbiol , vol.4 , pp. 883-897
    • Daniels, C.1    Griffiths, C.2    Cowles, B.3    Lam, J.S.4
  • 13
    • 17644381899 scopus 로고    scopus 로고
    • Functional characterization of WaaL, a ligase associated with linking O-antigen polysaccharide to the core of Pseudomonas aeruginosa lipopolysaccharide
    • Abeyrathne PD, Daniels C, Poon KK, Matewish MJ, Lam JS. 2005. Functional characterization of WaaL, a ligase associated with linking O-antigen polysaccharide to the core of Pseudomonas aeruginosa lipopolysaccharide. J. Bacteriol. 187:3002-3012.
    • (2005) J. Bacteriol , vol.187 , pp. 3002-3012
    • Abeyrathne, P.D.1    Daniels, C.2    Poon, K.K.3    Matewish, M.J.4    Lam, J.S.5
  • 14
    • 34547860486 scopus 로고    scopus 로고
    • WaaL of Pseudomonas aeruginosa utilizes ATP in in vitro ligation of O antigen onto lipid A-core
    • Abeyrathne PD, Lam JS. 2007. WaaL of Pseudomonas aeruginosa utilizes ATP in in vitro ligation of O antigen onto lipid A-core. Mol. Microbiol. 65:1345-1359.
    • (2007) Mol. Microbiol , vol.65 , pp. 1345-1359
    • Abeyrathne, P.D.1    Lam, J.S.2
  • 17
    • 64649085938 scopus 로고    scopus 로고
    • Multidrug efflux transporters in the MATE family
    • Kuroda T, Tsuchiya T. 2009. Multidrug efflux transporters in the MATE family. Biochim. Biophys. Acta 1794:763-768.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 763-768
    • Kuroda, T.1    Tsuchiya, T.2
  • 18
    • 77958596325 scopus 로고    scopus 로고
    • Structure of a cation-bound multidrug and toxic compound extrusion transporter
    • He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G. 2010. Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature 467:991-994.
    • (2010) Nature , vol.467 , pp. 991-994
    • He, X.1    Szewczyk, P.2    Karyakin, A.3    Evin, M.4    Hong, W.X.5    Zhang, Q.6    Chang, G.7
  • 19
    • 28044441589 scopus 로고    scopus 로고
    • Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1
    • Begum A, Rahman MM, Ogawa W, Mizushima T, Kuroda T, Tsuchiya T. 2005. Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1. Microbiol. Immunol. 49:949-957.
    • (2005) Microbiol. Immunol , vol.49 , pp. 949-957
    • Begum, A.1    Rahman, M.M.2    Ogawa, W.3    Mizushima, T.4    Kuroda, T.5    Tsuchiya, T.6
  • 20
    • 0346991732 scopus 로고    scopus 로고
    • An H-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa
    • He GX, Kuroda T, Mima T, Morita Y, Mizushima T, Tsuchiya T. 2004. An H-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. J. Bacteriol. 186: 262-265.
    • (2004) J. Bacteriol , vol.186 , pp. 262-265
    • He, G.X.1    Kuroda, T.2    Mima, T.3    Morita, Y.4    Mizushima, T.5    Tsuchiya, T.6
  • 21
    • 0038647631 scopus 로고    scopus 로고
    • Gene cloning and characterization of VcrM, a Na-coupled multidrug efflux pump, from Vibrio cholerae non-O1
    • Huda MN, Chen J, Morita Y, Kuroda T, Mizushima T, Tsuchiya T. 2003. Gene cloning and characterization of VcrM, a Na-coupled multidrug efflux pump, from Vibrio cholerae non-O1. Microbiol. Immunol. 47:419-427.
    • (2003) Microbiol. Immunol , vol.47 , pp. 419-427
    • Huda, M.N.1    Chen, J.2    Morita, Y.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 22
    • 0038607122 scopus 로고    scopus 로고
    • Evidence that the wzxE gene of Escherichia coli K-12 encodes a protein involved in the transbilayer movement of a trisaccharide-lipid intermediate in the assembly of enterobacterial common antigen
    • Rick PD, Barr K, Sankaran K, Kajimura J, Rush JS, Waechter CJ. 2003. Evidence that the wzxE gene of Escherichia coli K-12 encodes a protein involved in the transbilayer movement of a trisaccharide-lipid intermediate in the assembly of enterobacterial common antigen. J. Biol. Chem. 278:16534-16542.
    • (2003) J. Biol. Chem , vol.278 , pp. 16534-16542
    • Rick, P.D.1    Barr, K.2    Sankaran, K.3    Kajimura, J.4    Rush, J.S.5    Waechter, C.J.6
  • 24
    • 33645454462 scopus 로고    scopus 로고
    • Optimization of membrane protein overexpression and purification using GFP fusions
    • Drew D, Lerch M, Kunji E, Slotboom DJ, de Gier JW. 2006. Optimization of membrane protein overexpression and purification using GFP fusions. Nat. Methods 3:303-313.
    • (2006) Nat. Methods , vol.3 , pp. 303-313
    • Drew, D.1    Lerch, M.2    Kunji, E.3    Slotboom, D.J.4    de Gier, J.W.5
  • 25
    • 84868243529 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (Ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner
    • Eckford PD, Li C, Ramjeesingh M, Bear CE. 2012. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (Ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. J. Biol. Chem. 287:36639-36649.
    • (2012) J. Biol. Chem , vol.287 , pp. 36639-36649
    • Eckford, P.D.1    Li, C.2    Ramjeesingh, M.3    Bear, C.E.4
  • 27
    • 0036134936 scopus 로고    scopus 로고
    • VmrA, a member of a novel class of Na-coupled multidrug efflux pumps from Vibrio parahaemolyticus
    • Chen J, Morita Y, Huda MN, Kuroda T, Mizushima T, Tsuchiya T. 2002. VmrA, a member of a novel class of Na-coupled multidrug efflux pumps from Vibrio parahaemolyticus. J. Bacteriol. 184:572-576.
    • (2002) J. Bacteriol , vol.184 , pp. 572-576
    • Chen, J.1    Morita, Y.2    Huda, M.N.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 28
    • 0035949635 scopus 로고    scopus 로고
    • Na-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium
    • Huda MN, Morita Y, Kuroda T, Mizushima T, Tsuchiya T. 2001. Na-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium. FEMS Microbiol. Lett. 203:235-239.
    • (2001) FEMS Microbiol. Lett , vol.203 , pp. 235-239
    • Huda, M.N.1    Morita, Y.2    Kuroda, T.3    Mizushima, T.4    Tsuchiya, T.5
  • 29
    • 50949102768 scopus 로고    scopus 로고
    • Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob
    • Long F, Rouquette-Loughlin C, Shafer WM, Yu EW. 2008. Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob. Agents Chemother. 52:3052-3060.
    • (2008) Agents Chemother , vol.52 , pp. 3052-3060
    • Long, F.1    Rouquette-Loughlin, C.2    Shafer, W.M.3    Yu, E.W.4
  • 30
    • 0034459552 scopus 로고    scopus 로고
    • NorM of Vibrio parahaemolyticus is an Na-driven multidrug efflux pump
    • Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T. 2000. NorM of Vibrio parahaemolyticus is an Na-driven multidrug efflux pump. J. Bacteriol. 182:6694-6697.
    • (2000) J. Bacteriol , vol.182 , pp. 6694-6697
    • Morita, Y.1    Kataoka, A.2    Shiota, S.3    Mizushima, T.4    Tsuchiya, T.5
  • 31
    • 84862192588 scopus 로고    scopus 로고
    • Accurate de novo structure prediction of large transmembrane protein domains using fragment-assembly and correlated mutation analysis
    • doi: 10.1073/pnas.1120036109
    • Nugent T, Jones DT. 2012. Accurate de novo structure prediction of large transmembrane protein domains using fragment-assembly and correlated mutation analysis. Proc. Natl. Acad. Sci. U. S. A. 109:E1540-E1547. doi: 10.1073/pnas.1120036109.
    • (2012) Proc. Natl. Acad. Sci. U. S. A , vol.109
    • Nugent, T.1    Jones, D.T.2
  • 32
    • 84858133323 scopus 로고    scopus 로고
    • Homology modeling of transporter proteins (carriers and ion channels)
    • In Orry AJW, Abagyan R, Humana Press, New York, NY
    • Ravna AW, Sylte I. 2012. Homology modeling of transporter proteins (carriers and ion channels), p 281-299. In Orry AJW, Abagyan R (ed), Homology modeling: methods and Protocols, vol 857. Humana Press, New York, NY.
    • (2012) Homology Modeling: Methods and Protocols , vol.857 , pp. 281-299
    • Ravna, A.W.1    Sylte, I.2
  • 33
    • 17644392830 scopus 로고    scopus 로고
    • TM-align: A protein structure alignment algorithm based on the TM-score
    • Zhang Y, Skolnick J. 2005. TM-align: a protein structure alignment algorithm based on the TM-score. Nucleic Acids Res. 33:2302-2309.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2302-2309
    • Zhang, Y.1    Skolnick, J.2
  • 34
    • 77958533259 scopus 로고    scopus 로고
    • Structural biology: Last of the multidrug transporters
    • van Veen HW. 2010. Structural biology: last of the multidrug transporters. Nature 467:926-927.
    • (2010) Nature , vol.467 , pp. 926-927
    • van Veen, H.W.1
  • 35
    • 0025877963 scopus 로고
    • Spectral and photophysical studies of benzo[c]xanthene dyes: Dual emission pH sensors
    • Whitaker JE, Haugland RP, Prendergast FG. 1991. Spectral and photophysical studies of benzo[c]xanthene dyes: dual emission pH sensors. Anal. Biochem. 194:330-344.
    • (1991) Anal. Biochem , vol.194 , pp. 330-344
    • Whitaker, J.E.1    Haugland, R.P.2    Prendergast, F.G.3
  • 36
    • 78650297251 scopus 로고    scopus 로고
    • The structural basis of secondary active transport mechanisms
    • Forrest LR, Krämer R, Ziegler C. 2011. The structural basis of secondary active transport mechanisms. Biochim. Biophys. Acta 1807:167-188.
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 167-188
    • Forrest, L.R.1    Krämer, R.2    Ziegler, C.3
  • 37
    • 33746548445 scopus 로고    scopus 로고
    • Identification and functional characterization of a new human kidney-specific H /organic cation antiporter, kidneyspecific multidrug and toxin extrusion 2
    • Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, Ogawa O, Inui KJ. 2006. Identification and functional characterization of a new human kidney-specific H /organic cation antiporter, kidneyspecific multidrug and toxin extrusion 2. J. Am. Soc. Nephrol. 17: 2127-2135.
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 2127-2135
    • Masuda, S.1    Terada, T.2    Yonezawa, A.3    Tanihara, Y.4    Kishimoto, K.5    Katsura, T.6    Ogawa, O.7    Inui, K.J.8
  • 40
    • 84856927958 scopus 로고    scopus 로고
    • Ion binding and internal hydration in the multidrug resistance secondary active transporter NorM investigated by molecular dynamics simulations
    • Vanni S, Campomanes P, Marcia M, Rothlisberger U. 2012. Ion binding and internal hydration in the multidrug resistance secondary active transporter NorM investigated by molecular dynamics simulations. Biochemistry 51:1281-1287.
    • (2012) Biochemistry , vol.51 , pp. 1281-1287
    • Vanni, S.1    Campomanes, P.2    Marcia, M.3    Rothlisberger, U.4
  • 41
    • 14244266607 scopus 로고    scopus 로고
    • Identification of essential amino acid residues of the NorM Na /multidrug antiporter in Vibrio parahaemolyticus
    • Otsuka M, Yasuda M, Morita Y, Otsuka C, Tsuchiya T, Omote H, Moriyama Y. 2005. Identification of essential amino acid residues of the NorM Na /multidrug antiporter in Vibrio parahaemolyticus. J. Bacteriol. 187:1552-1558.
    • (2005) J. Bacteriol , vol.187 , pp. 1552-1558
    • Otsuka, M.1    Yasuda, M.2    Morita, Y.3    Otsuka, C.4    Tsuchiya, T.5    Omote, H.6    Moriyama, Y.7
  • 42
    • 78649365640 scopus 로고    scopus 로고
    • Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli
    • Marolda CL, Li B, Lung M, Yang M, Hanuszkiewicz A, Rosales AR, Valvano MA. 2010. Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli. J. Bacteriol. 192:6160-6171.
    • (2010) J. Bacteriol , vol.192 , pp. 6160-6171
    • Marolda, C.L.1    Li, B.2    Lung, M.3    Yang, M.4    Hanuszkiewicz, A.5    Rosales, A.R.6    Valvano, M.A.7
  • 43
    • 84885445028 scopus 로고    scopus 로고
    • Topological mapping methods for ÷-helical bacterial membrane proteins-an update and a guide
    • doi:10.1002/mbo3.72
    • Islam ST, Lam JS. 2013. Topological mapping methods for ÷-helical bacterial membrane proteins-an update and a guide. MicrobiologyOpen 2:350-364. doi:10.1002/mbo3.72.
    • (2013) MicrobiologyOpen , vol.2 , pp. 350-364
    • Islam, S.T.1    Lam, J.S.2
  • 44
    • 79951630927 scopus 로고    scopus 로고
    • Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli
    • Marolda CL, Li B, Lung M, Yang M, Hanuszkiewicz A, Rosales AR, Valvano MA. 2011. Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli. J. Bacteriol. 193:1291-1292.
    • (2011) J. Bacteriol , vol.193 , pp. 1291-1292
    • Marolda, C.L.1    Li, B.2    Lung, M.3    Yang, M.4    Hanuszkiewicz, A.5    Rosales, A.R.6    Valvano, M.A.7
  • 45
    • 0346734230 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd
    • Xu XJ, Su XZ, Morita Y, Kuroda T, Mizushima T, Tsuchiya T. 2003. Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd. Microbiol. Immunol. 47: 937-943.
    • (2003) Microbiol. Immunol , vol.47 , pp. 937-943
    • Xu, X.J.1    Su, X.Z.2    Morita, Y.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 46
    • 78650075360 scopus 로고    scopus 로고
    • Investigation of cationinteractions in sugar-binding proteins
    • Elumalai P, Rajasekaran M, Liu HL, Chen C. 2010. Investigation of cationinteractions in sugar-binding proteins. Protoplasma 247:13-24.
    • (2010) Protoplasma , vol.247 , pp. 13-24
    • Elumalai, P.1    Rajasekaran, M.2    Liu, H.L.3    Chen, C.4
  • 47
    • 33847317012 scopus 로고    scopus 로고
    • Sequence and structural features of carbohydrate binding in proteins and assessment of predictability using a neural network
    • doi:10.1186/1472-6807-7-1
    • Malik A, Ahmad S. 2007. Sequence and structural features of carbohydrate binding in proteins and assessment of predictability using a neural network. BMC Struct. Biol. 7:1. doi:10.1186/1472-6807-7-1.
    • (2007) BMC Struct. Biol , vol.7 , pp. 1
    • Malik, A.1    Ahmad, S.2
  • 48
    • 84055217548 scopus 로고    scopus 로고
    • Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator
    • Alkhouri B, Denning RA, Kim Chiaw P, Eckford PD, Yu W, Li C, Bogojeski JJ, Bear CE, Viirre RD. 2011. Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator. J. Med. Chem. 54:8693-8701.
    • (2011) J. Med. Chem , vol.54 , pp. 8693-8701
    • Alkhouri, B.1    Denning, R.A.2    Kim, C.P.3    Eckford, P.D.4    Yu, W.5    Li, C.6    Bogojeski, J.J.7    Bear, C.E.8    Viirre, R.D.9
  • 49
    • 59849091513 scopus 로고    scopus 로고
    • Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease
    • Pasyk S, Li C, Ramjeesingh M, Bear CE. 2009. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem. J. 418:185-190.
    • (2009) Biochem. J , vol.418 , pp. 185-190
    • Pasyk, S.1    Li, C.2    Ramjeesingh, M.3    Bear, C.E.4
  • 50
    • 80055082271 scopus 로고    scopus 로고
    • Accelerated profile HMM searches
    • Eddy SR. 2011. Accelerated profile HMM searches. PLOS Comput. Biol. 7:e1002195. http://dx.doi.org/10.1371/journal.pcbi.1002195.
    • (2011) PLOS Comput. Biol , vol.7
    • Eddy, S.R.1
  • 52
    • 84856090271 scopus 로고    scopus 로고
    • PSICOV: Precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments
    • Jones DT, Buchan DW, Cozzetto D, Pontil M. 2012. PSICOV: precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments. Bioinformatics 28:184-190.
    • (2012) Bioinformatics , vol.28 , pp. 184-190
    • Jones, D.T.1    Buchan, D.W.2    Cozzetto, D.3    Pontil, M.4
  • 54
    • 84866158866 scopus 로고    scopus 로고
    • Detecting pore-lining regions in transmembrane protein sequences
    • doi:10.1186/1471-2105-13-169
    • Nugent T, Jones DT. 2012. Detecting pore-lining regions in transmembrane protein sequences. BMC Bioinformatics 13:169. doi:10.1186/1471-2105-13-169.
    • (2012) BMC Bioinformatics , vol.13 , pp. 169
    • Nugent, T.1    Jones, D.T.2
  • 55
    • 77951961719 scopus 로고    scopus 로고
    • How significant is a protein structure similarity with TM-score 0.5?
    • Xu J, Zhang Y. 2010. How significant is a protein structure similarity with TM-score 0.5? Bioinformatics 26:889-895.
    • (2010) Bioinformatics , vol.26 , pp. 889-895
    • Xu, J.1    Zhang, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.