Reduced risk of distant recurrence after adjuvant chemotherapy in patients with stage III colon cancer aged 75 years or older

Annals of Oncology

Volumn 24, Issue 11, 2013, Pages 2839-2844

  van Erning, F N ^a   Creemers, G J ^b   De Hingh, I H J T ^b   Loosveld, O J L ^c   Goey, S H ^d   Lemmens, V E P P ^a,e  

^a Eindhoven Cancer Registry   (Netherlands)

^b CATHARINA HOSPITAL   (Netherlands)

^c AMPHIA HOSPITAL   (Netherlands)

^d CPRLab   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Adjuvant chemotherapy; Colon cancer; Elderly; Population based; Risk of recurrence

Indexed keywords

ANTINEOPLASTIC AGENT;

AGE DISTRIBUTION; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CANCER STAGING; COLON CANCER; COLON SURGERY; CONTROLLED STUDY; DISTANT METASTASIS; ELDERLY CARE; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; NETHERLANDS; OVERALL SURVIVAL; POPULATION RESEARCH; PRIORITY JOURNAL; RECURRENCE RISK; RISK FACTOR; RISK REDUCTION; SOCIAL STATUS;

ADJUVANT CHEMOTHERAPY; COLON CANCER; ELDERLY; POPULATION-BASED; RISK OF RECURRENCE;

AGE FACTORS; AGED; AGED, 80 AND OVER; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; NEOPLASM STAGING; NETHERLANDS; PROPORTIONAL HAZARDS MODELS; RECURRENCE; RISK FACTORS; TREATMENT OUTCOME;

EID: 84887094501     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdt334     Document Type: Article

References (26)

1. National Working Group on Gastrointestinal Cancers. Guideline: Colon Cancer. The Netherlands: Comprehensive Cancer Centre 2008.
2. Elferink MA, Wouters MW, Krijnen P et al. Disparities in quality of care for colon cancer between hospitals in the Netherlands. Eur J Surg Oncol 2010; 36(Suppl 1): S64-S73.
3. Andre T, Boni C, Navarro M et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009; 27: 3109-3116.
4. Chau I, Cunningham D. Adjuvant therapy in colon cancer-what, when and how? Ann Oncol 2006; 17: 1347-1359.
5. Twelves C, Wong A, Nowacki MP et al. Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 2005; 352: 2696-2704.
6. Moertel CG, Fleming TR, Macdonald JS et al. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 1995; 122: 321-326.
7. Andre T, Boni C, Mounedji-Boudiaf L et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350: 2343-2351.
8. Kuebler JP, Wieand HS, O'Connell MJ et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007; 25: 2198-2204.
9. Goldberg RM, Tabah-Fisch I, Bleiberg H et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 2006; 24: 4085-4091.
10. Sargent DJ, Goldberg RM, Jacobson SD et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-1097.
11. Sanoff HK, Goldberg RM. Colorectal cancer treatment in older patients. Gastrointest Cancer Res 2007; 1: 248-253.
12. Abraham A, Habermann EB, Rothenberger DA et al. Adjuvant chemotherapy for stage III colon cancer in the oldest old: results beyond clinical guidelines. Cancer 2013; 119: 395-403.
13. Schrag D, Cramer LD, Bach PB et al. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 2001; 93: 850-857.
14. Kahn KL, Adams JL, Weeks JC et al. Adjuvant chemotherapy use and adverse events among older patients with stage III colon cancer. JAMA 2010; 303: 1037-1045.
15. van Steenbergen LN, Rutten HJ, Creemers GJ et al. Large age and hospitaldependent variation in administration of adjuvant chemotherapy for stage III colon cancer in southern Netherlands. Ann Oncol 2010; 21: 1273-1278.
16. Lemmens VE, van Halteren AH, Janssen-Heijnen ML et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol 2005; 16: 767-772.
17. van Steenbergen LN, Lemmens VE, Rutten HJ et al. Increased adjuvant treatment and improved survival in elderly stage III colon cancer patients in The Netherlands. Ann Oncol 2012; 23: 2805-2811.
18. Sanoff HK, Carpenter WR, Sturmer T et al. Effect of adjuvant chemotherapy on survival of patients with stage III colon cancer diagnosed after age 75 years. J Clin Oncol 2012; 30: 2624-2634.
19. Power DG, Lichtman SM. Chemotherapy for the elderly patient with colorectal cancer. Cancer J 2010; 16: 241-252.
20. Manfredi S, Bouvier AM, Lepage C et al. Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population. Br J Surg 2006; 93: 1115-1122.
21. Sargent D, Sobrero A, Grothey A et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 2009; 27: 872-877.
22. Twelves C, Schmoll H, O'Connell M et al. Effect of oxaliplatin-based adjuvant therapy on post-relapse survival (PRS) in patients with stage III colon cancer: a pooled analysis of individual patient data from four randomized controlled trials. J Clin Oncol 2012; 30(suppl; abstr 3523).
23. Laubert T, Habermann JK, Hemmelmann C et al. Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas. BMC Gastroenterol 2012; 12: 24.
24. Abrams TA, Brightly R, Mao J et al. Patterns of adjuvant chemotherapy use in a population-based cohort of patients with resected stage II or III colon cancer. J Clin Oncol 2011; 29: 3255-3262.
25. Hsiao FY, Mullins CD, Onukwugha E et al. Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a 'real world' analysis using Surveillance, Epidemiology, and End Results-Medicare data. J Am Geriatr Soc 2011; 59: 1717-1723.
26. Haller DG, O'Connell M, Cartwright TH et al. Impact of age and medical comorbidity (MC) on adjuvant treatment outcomes for stage III colon cancer (CC): a pooled analysis of individual patient data from four randomized controlled trials. J Clin Oncol 2012; 30(suppl; abstr 3522).