PHACOS, a functionalized bacterial polyester with bactericidal activity against methicillin-resistant Staphylococcus aureus

Biomaterials

Volumn 35, Issue 1, 2014, Pages 14-24

  Dinjaski, Nina ^a   Fernández Gutiérrez, Mar ^b,f   Selvam, Shivaram ^c,d   Parra Ruiz, Francisco J ^b,f   Lehman, Susan M ^c,d   San Román, Julio ^b,f   García, Ernesto ^a,e   García, José L ^a   García, Andrés J ^c,d   Prieto, María Auxiliadora ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS   (Spain)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Antimicrobial polymers; Biofilm; Biomaterial infection; Functionalized polyhydroxyalkanoate; Methicillin resistant Staphylococcus aureus

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTIBACTERIAL PROPERTIES; ANTIMICROBIAL POLYMERS; BACTERICIDAL ACTIVITY; FLUORESCENCE IMAGING; IMPLANT-ASSOCIATED INFECTION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; POLY-HYDROXYALKANOATE;

ADHESION; BACTERIA; BIOFILMS; BIOLOGICAL MATERIALS; CELL CULTURE; MACROPHAGES; POLYMERS;

BIOMATERIALS;

OCTANOIC ACID DERIVATIVE; POLY(3 HYDROXYOCTANOATECO CO HYDROXYHEXANOATE); POLYESTER; POLYETHYLENE TEREPHTHALATE; POLYHYDROXYALKANOIC ACID; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MURINAE;

ANTIMICROBIAL POLYMERS; BIOFILM; BIOMATERIAL INFECTION; FUNCTIONALIZED POLYHYDROXYALKANOATE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BACTERIA; BIOFILMS; CELL ADHESION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS;

EID: 84887055727     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.059     Document Type: Article

References (49)

1. Kiedrowski M.R., Horswill A.R. New approaches for treating staphylococcal biofilm infections. Ann N Y Acad Sci 2011, 1241:104-121.
2. DeLeo F.R., Chambers H.F. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. JClin Invest 2009, 119:2464-2474.
3. Darouiche R.O. Treatment of infections associated with surgical implants. NEngl J Med 2004, 350:1422-1429.
4. Grundmann H., Aires-de-Sousa M., Boyce J., Tiemersma E. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 2006, 368:874-885.
5. Klein E., Smith D.L., Laxminarayan R. Community-associated methicillin-resistant Staphylococcus aureus in outpatients, United States, 1999-2006. Emerg Infect Dis 2009, 15:1925-1930.
6. Cornell R.J., Donaruma L.G. 2-Methacryloxytropones. Intermediates for the synthesis of biologically active polymers. JMed Chem 1965, 8:388-390.
7. Siedenbiedel F., Tiller J.C. Antimicrobial polymers in solution and on surfaces: overview and functional principles. Polymers 2012, 4:46-71.
8. Gomes M.E., Reis R.L. Biodegradable polymers and composites in biomedical applications: from catgut to tissue engineering. Part 1. Available systems and their properties. Int Mater Rev 2004, 49:261-273.
9. Chen G.-Q., Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials 2005, 26:6565-6578.
10. Chen G.-Q. Amicrobial polyhydroxyalkanoates (PHA) based bio- and materials industry. Chem Soc Rev 2009, 38:2434-2446.
11. Steinbüchel A., Valentin H.E. Diversity of bacterial polyhydroxyalkanoic acids. FEMS Microbiol Lett 1995, 128:219-228.
12. Hazer D.B., Kiliçay E., Hazer B. Poly(3-hydroxyalkanoate)s: diversification and biomedical applications. A state of the art review. Mater Sci Eng C 2012, 32:637-647.
13. Escapa I.F., Morales V., Martino V.P., Pollet E., Avérous L., García J.L., et al. Disruption of β-oxidation pathway in Pseudomonas putida KT2442 to produce new functionalized PHAs with thioester groups. Appl Microbiol Biotechnol 2011, 89:1583-1598.
14. Furrer P., Panke S., Zinn M. Efficient recovery of low endotoxin medium-chain-length poly([R]-3-hydroxyalkanoate) from bacterial biomass. JMicrobiol Methods 2007, 69:206-213.
15. Guideline on validation of the Limulus amebocyte lysate test as an end-product endotoxin test for human an animal parenteral drugs, biological products, and medical devices 1987, FDA, Rockville, MD. http://www.gmpua.com/Validation/Method/LAL/FDAGuidelineForTheValidationA .pdf, U.S. Department of Health and Human Services FaDA (Ed.).
16. Moscoso M., García E., López R. Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion. JBacteriol 2006, 188:7785-7795.
17. Sambrook J., Russell D.W. Molecular cloning. A laboratory manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
18. CLSI Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, document M07-A8 2008, Clinical and Laboratory Standards Institute, Wayne, PA.
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. JImmunol Methods 1983, 65:55-63.
20. Wang S.-Y., Lan X.-Y., Xiao J.-H., Yang J.-C., Kao Y.-T., Chang S.-T. Antiinflammatory activity of Lindera erythrocarpa fruits. Phytother Res 2008, 22:213-216.
21. Schmidt H.H.W., Kelm M. Determination of nitrite and nitrate by the Griess reaction. Methods in nitric oxide research 1996, 491-497. Wiley, Chichester, UK. M. Feelisch, J.S. Stamler (Eds.).
22. Kundu K., Knight S.F., Willett N., Lee S., Taylor W.R., Murthy N. Hydrocyanines: a class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and invivo. Angew Chem Int Ed Engl 2009, 48:299-303.
23. p. Guide for the care and use of laboratory animals. Committee on care and use of laboratory animals of the Institute of Laboratory Animal Resources, Commission on life sciences 1985, National Research Council, National Research Council, Bethesda, MD, NIH Publication No. 85-23. United States Department of Health and Human Services PHS, National Institutes of Health (Ed.).
24. Selvam S., Kundu K., Templeman K.L., Murthy N., García A.J. Minimally invasive, longitudinal monitoring of biomaterial-associated inflammation by fluorescence imaging. Biomaterials 2011, 32:7785-7792.
25. Mauclaire L., Brombacher E., Bünger J.D., Zinn M. Factors controlling bacterial attachment and biofilm formation on medium-chain-length polyhydroxyalkanoates (mcl-PHAs). Colloids Surf B Biointerfaces 2010, 76:104-111.
26. Kojima M., Morisaki T., Izuhara K., Uchiyama A., Matsunari Y., Katano M., et al. Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-κB activation. Oncogene 2000, 19:1225-1231.
27. Lin P.W., Myers L.E.S., Ray L., Song S.-C., Nasr T.R., Berardinelli A.J., et al. Lactobacillus rhamnosus blocks inflammatory signaling invivo via reactive oxygen species generation. Free Radic Biol Med 2009, 47:1205-1211.
28. Zimmerli W., Trampuz A., Ochsner P.E. Prosthetic-joint infections. NEngl J Med 2004, 351:1645-1654.
29. Butler M.S., Cooper M.A. Antibiotics in the clinical pipeline in 2011. JAntibiot 2011, 64:413-425.
30. Kuroda K., Caputo G.A. Antimicrobial polymers as synthetic mimics of host-defense peptides. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2013, 5:49-66.
31. Mah T.-F.C., O'Toole G.A. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001, 9:34-39.
32. Harris L.G., Richards R.G. Staphylococci and implant surfaces: a review. Injury 2006, 37:S3-S14.
33. Lejars M., Margaillan A., Bressy C. Fouling release coatings: a nontoxic alternative to biocidal antifouling coatings. Chem Rev 2012, 112:4347-4390.
34. Wang Y., Schanze K.S., Chi E.Y., Whitten D.G. When worlds collide: interactions at the interface between biological systems and synthetic cationic conjugated polyelectrolytes and oligomers. Langmuir 2013, 10.1021/la4012263.
35. Sandoval Á., Arias-Barrau E., Bermejo F., Cañedo L., Naharro G., Olivera E.R., et al. Production of 3-hydroxy-n-phenylalkanoic acids by a genetically engineered strain of Pseudomonas putida. Appl Microbiol Biotechnol 2005, 67:97-105.
36. Ruth K., Grubelnik A., Hartmann R., Egli T., Zinn M., Ren Q. Efficient production of (R)-3-hydroxycarboxylic acids by biotechnological conversion of polyhydroxyalkanoates and their purification. Biomacromolecules 2006, 8:279-286.
37. Lienkamp K., Madkour A.E., Musante A., Nelson C.F., Nüsslein K., Tew G.N. Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach. JAm Chem Soc 2008, 130:9836-9843.
38. Epand R.F., Sarig H., Mor A., Epand R.M. Cell-wall interactions and the selective bacteriostatic activity of a miniature oligo-acyl-lysyl. Biophys J 2009, 97:2250-2257.
39. Raafat D., von Bargen K., Haas A., Sahl H.-G. Insights into the mode of action of chitosan as an antibacterial compound. Appl Environ Microbiol 2008, 74:3764-3773.
40. Gibney K.A., Sovadinova I., Lopez A.I., Urban M., Ridgway Z., Caputo G.A., et al. Poly(ethylene imine)s as antimicrobial agents with selective activity. Macromol Biosci 2012, 12:1279-1289.
41. Otto M. Molecular basis of Staphylococcus epidermidis infections. Semin Immunopathol 2012, 34:201-214.
42. Olofsson A.-C., Hermansson M., Elwing H. NAcetyl-L-cysteine affects growth, extracellular polysaccharide production, and bacterial biofilm formation on solid surfaces. Appl Environ Microbiol 2003, 69:4814-4822.
43. Pérez-Giraldo C., Rodríguez-Benito A., Morán F.J., Hurtado C., Blanco M.T., Gómez-García A.C. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis. JAntimicrob Chemother 1997, 39:643-646.
44. Hernandez M.D., Mansouri M.D., Aslam S., Zeluff B., Darouiche R.O. Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. Infect Control Hosp Epidemiol 2009, 30:190-192.
45. Timofeeva L., Kleshcheva N. Antimicrobial polymers: mechanism of action, factors of activity, and applications. Appl Microbiol Biotechnol 2011, 89:475-492.
46. Zinn M., Witholt B., Egli T. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev 2001, 53:5-21.
47. Wiggam M.I., O'Kane M.J., Harper R., Atkinson A.B., Hadden D.R., Trimble E.R., et al. Treatment of diabetic ketocidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint oemergency management. A randomized controlled study. Diabetes Care 1997, 20:137-152.
48. Reusch R.N. Transmembrane ion transport by polyphosphate/poly-(R)-3-hydroxybutyrate complexes. Biochemistry (Mosc) 2000, 65:280-295.
49. Tortajada M., da Silva F.L., Prieto M.A. Secon-generation functionalized médium-chain-length polyhydroxyalkanoates: th gateway to high-value bioplastic applications. Int Microbiol 2013, 16:1-15.