Sprint interval training in hypoxia stimulates glycolytic enzyme activity

Medicine and Science in Sports and Exercise

Volumn 45, Issue 11, 2013, Pages 2166-2174

  Puype, Joke ^a   Van Proeyen, Karen ^a   Raymackers, Jean Marc ^b   Deldicque, Louise ^a   Hespel, Peter ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

anaerobic threshold; endurance performance; High intensity interval training; muscle lactate transporter; phosphofructokinase

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CITRATE SYNTHASE; COTRANSPORTER; GLYCOGEN; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANAEROBIC THRESHOLD; ANOXIA; ARTICLE; BICYCLE; ENDURANCE; ENZYMOLOGY; EXERCISE; EXERCISE TEST; HUMAN; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; QUADRICEPS FEMORIS MUSCLE; YOUNG ADULT;

ADOLESCENT; ADULT; ANAEROBIC THRESHOLD; ANOXIA; BICYCLING; CITRATE (SI)-SYNTHASE; EXERCISE TEST; GLYCOGEN; HUMANS; MALE; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; OXYGEN CONSUMPTION; PHOSPHOFRUCTOKINASES; PHYSICAL CONDITIONING, HUMAN; PHYSICAL ENDURANCE; QUADRICEPS MUSCLE; SYMPORTERS; YOUNG ADULT;

EID: 84887044448     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31829734ae     Document Type: Article

References (40)

1. Abbiss CR, Karagounis LG, Laursen PB, et al. Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. J Appl Physiol. 2011;110(5):1248-55.
2. Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: cellular mechanisms. Physiol Rev. 2008;88(1):287-332.
3. Barnett C, Carey M, Proietto J, Cerin E, Febbraio MA, Jenkins D. Muscle metabolism during sprint exercise in man: influence of sprint training. J Sci Med Sport. 2004;7(3):314-22.
4. Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D. The effects of short-term sprint training on MCT expression in moderately endurance-trained runners. Eur J Appl Physiol. 2006; 96(6):636-43.
5. Burgomaster KA, Cermak NM, Phillips SM, Benton CR, Bonen A, Gibala MJ. Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Am J Physiol Regul Integr Comp Physiol. 2007;292(5):R1970-6.
6. Burgomaster KA, Heigenhauser GJ, Gibala MJ. Effect of shortterm sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance. J Appl Physiol. 2006;100(6):2041-7.
7. Burgomaster KA, Howarth KR, Phillips SM, et al. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 2008; 586(1):151-60.
8. Burgomaster KA, Hughes SC, Heigenhauser GJ, Bradwell SN, Gibala MJ. Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol. 2005;98(6):1985-90.
9. Chen ZP, McConell GK, Michell BJ, Snow RJ, Canny BJ, Kemp BE. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab. 2000;279(5):E1202-6.
10. Clark SA, Chen ZP, Murphy KT, et al. Intensified exercise training does not alter AMPK signaling in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004;286(5):E737-43.
11. den Hoed M, Hesselink MKC, van Kranenburg GPJ, Westerterp KR. Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity. J Appl Physiol. 2008; 105(2):561-8.
12. Dubouchaud H, Butterfield GE, Wolfel EE, Bergman BC, Brooks GA. Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am J Physiol Endocrinol Metab. 2000;278(4):E571-9.
13. Gibala MJ, Little JP, van EM, et al. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006; 575(Pt 3):901-11.
14. Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol. 2009;106(3):929-34.
15. Gladden LB. Lactate metabolism: a new paradigm for the third millennium. J Physiol. 2004;558(Pt 1):5-30.
16. Jacobs I, Esbjornsson M, Sylven C, Holm I, Jansson E. Sprint training effects on muscle myoglobin, enzymes, fiber types, and blood lactate. Med Sci Sports Exerc. 1987;19(4):368-74.
17. Laursen PB, Jenkins DG. The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes. Sports Med. 2002;32(1):53-73.
18. Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1alpha and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2011;300(6):R1303-10.
19. Lowry OH, Passoneau JV. A Flexible System of Enzymatic Analysis. New York: Academic Press, 1972.
20. MacDougall JD, Hicks AL, MacDonald JR, McKelvie RS, Green HJ, Smith KM. Muscle performance and enzymatic adaptations to sprint interval training. J Appl Physiol. 1998;84(6):2138-42.
21. Macpherson RE, Hazell TJ, Olver TD, Paterson DH, Lemon PW. Run sprint interval training improves aerobic performance but not maximal cardiac output. Med Sci Sports Exerc. 2011;43(1):115-22.
22. Melissa L, MacDougall JD, Tarnopolsky MA, Cipriano N, Green HJ. Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. Med Sci Sports Exerc. 1997; 29(2):238-43.
23. Millet GP, Roels B, Schmitt L, Woorons X, Richalet JP. Combining hypoxic methods for peak performance. Sports Med. 2010; 40(1):1-25.
24. Mohr M, Krustrup P, Nielsen JJ, et al. Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development. Am J Physiol Regul Integr Comp Physiol. 2007; 292(4):R1594-602.
25. Perry CG, Heigenhauser GJ, Bonen A, Spriet LL. High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle. Appl Physiol Nutr Metab. 2008;33(6):1112-23.
26. Philp A, Hargreaves M, Baar K. More than a store: regulatory roles for glycogen in skeletal muscle adaptation to exercise. Am J Physiol Endocrinol Metab. 2012;302(11):E1343-51.
27. Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009;418(2):261-75.
28. Saltin B, Nazar K, Costill DL, et al. The nature of the training response; peripheral and central adaptations of one-legged exercise. Acta Physiol Scand. 1976;96(3):289-305.
29. Schmutz S, Dapp C, Wittwer M, et al. A hypoxia complement differentiates the muscle response to endurance exercise. Exp Physiol. 2010;95(6):723-35.
30. Smith KJ, Billaut F. Influence of cerebral and muscle oxygenation on repeated-sprint ability. Eur J Appl Physiol. 2010;109(5): 989-99.
31. Spriet LL, Lindinger MI, McKelvie RS, Heigenhauser GJ, Jones NL. Muscle glycogenolysis and H+ concentration during maximal intermittent cycling. J Appl Physiol. 1989;66(1):8-13.
32. Thomas C, Perrey S, Lambert K, Hugon G, Mornet D, Mercier J. Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fatigue indexes in humans. J Appl Physiol. 2005;98(3):804-9.
33. Van Proeyen K, De Bock K, Hespel P. Training in the fasted state facilitates re-activation of eEF2 activity during recovery from endurance exercise. Eur J Appl Physiol. 2011;111(7):1297-305.
34. Van Proeyen K, Szlufcik K, Nielens H, Ramaekers M, Hespel P. Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J Appl Physiol. 2011;110(1):236-45.
35. Vogt M, Puntschart A, Geiser J, Zuleger C, Billeter R, Hoppeler H. Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol. 2001;91(1): 173-82.
36. 2max and performance with increasing altitude in endurance athletes. Eur J Appl Physiol. 2006;96(4):404-12.
37. Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002;16(10):1151-62.
38. Weyand PG, Lee CS, Martinez-Ruiz R, Bundle MW, Bellizzi MJ, Wright S. High-speed running performance is largely unaffected by hypoxic reductions in aerobic power. J Appl Physiol. 1999; 86(6):2059-64.
39. Yeo WK, Paton CD, Garnham AP, Burke LM, Carey AL, Hawley JA. Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. J Appl Physiol. 2008;105(5):1462-70.
40. Zoll J, Ponsot E, Dufour S, et al. Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts. J Appl Physiol. 2006;100(4):1258-66.