Dissipative particle dynamics studies of doxorubicin-loaded micelles assembled from four-arm star triblock polymers 4AS-PCL- b -PDEAEMA- b -PPEGMA and their pH-release mechanism

Journal of Physical Chemistry B

Volumn 117, Issue 43, 2013, Pages 13688-13697

  Nie, Shu Yu ^a   Sun, Yao ^a   Lin, Wen Jing ^a   Wu, Wen Sheng ^a,b   Guo, Xin Dong ^a   Qian, Yu ^a   Zhang, Li Juan ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b ZHAOQING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DISSIPATIVE PARTICLE DYNAMICS; ENCAPSULATION CAPACITY; ETHYL METHACRYLATES; OPTIMIZED SYSTEM; POLY(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE (PEG-MMA); SOLUBILITY PARAMETERS; THREE-LAYER STRUCTURES; TRIBLOCK POLYMERS;

DRUG PRODUCTS; MOLECULES; MORPHOLOGY; PH; POLYETHYLENE GLYCOLS; STARS;

MICELLES;

ANTINEOPLASTIC AGENT; DOXORUBICIN; METHACRYLIC ACID DERIVATIVE; POLYESTER;

ARTICLE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; MICELLE; MOLECULAR DYNAMICS; PARTICLE SIZE; PH; SOLUBILITY; SURFACE PROPERTY;

ANTINEOPLASTIC AGENTS; DOXORUBICIN; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHACRYLATES; MICELLES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PARTICLE SIZE; POLYESTERS; SOLUBILITY; SURFACE PROPERTIES;

EID: 84887043389     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp407529u     Document Type: Article

References (42)

1. Husseini, G. A.; Pitt, W. G. Micelles and Nanoparticles for Ultrasonic Drug and Gene Delivery Adv. Drug Delivery Rev. 2008, 60, 1137-1152
2. Davis, M. E.; Chen, Z.; Shin, D. M. Nanoparticle Therapeutics: an Emerging Treatment Modality for Cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
3. Schramm, O. G.; Pavlov, G. M.; van Erp, H. P.; Meier, M. A. R.; Hoogenboom, R.; Schubert, U. S. A Versatile Approach to Unimolecular Water-Soluble Carriers: ATRP of PEGMA with Hydrophobic Star-Shaped Polymeric Core Molecules as an Alternative for PEGylation Macromolecules 2009, 42, 1808-1816
4. He, E.; Ravi, P.; Tam, K. C. Synthesis and Self-Assembly Behavior of Four-Arm Poly(ethylene oxide)- b -poly(2-(diethylamino)ethyl methacrylate) Star Block Copolymer in Salt Solutions Langmuir 2007, 23, 2382-2388
5. Khanna, K.; Varshney, S.; Kakkar, A. Miktoarm Star Polymers: Advances in Synthesis, Self-assembly, and Applications Polym. Chem. 2010, 1, 1171-1185
6. Li, X.; Qian, Y.; Liu, T.; Hu, X.; Zhang, G.; You, Y.; Liu, S. Amphiphilic Multiarm Star Block Copolymer-Based Multifunctional Unimolecular Micelles for Cancer Targeted Drug Delivery and MR Imaging Biomaterials 2011, 32, 6595-6605
7. Iatridi, Z.; Tsitsilianis, C. Water-Soluble Stimuli Responsive Star-Shaped Segmented Macromolecules Polymers 2011, 3, 1911-1933
8. Jin, S.; Higashihara, T.; Jin, K. T.; Yoon, J.; Rho, Y.; Ahn, B.; Kim, J.; Hirao, A.; Ree, M. Synchrotron X-ray Scattering Characterization of the Molecular Structures of Star Polystyrenes with Varying Numbers of Arms J. Phys. Chem. B 2010, 114, 6247-6257
9. Lapienis, G. Star-Shaped Polymers having PEO Arms Prog. Polym. Sci. 2009, 34, 852-892
10. Zhu, W.; Nese, A.; Matyjaszewski, K. Amphiphilic PEG-grafted Poly (ester-carbonate)s: Synthesis and Diverse Nanostructures in Water J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 1942-1952
11. Jiang, G.; Xu, H. Synthesis and Evaluation of a Star Amphiphilic Block Copolymer from Poly(ε-caprolactone) and Poly(ethylene oxide) as Load and Release Carriers for Guest Molecules J. Appl. Polym. Sci. 2010, 118, 1372-1379
12. Liu, J.; Huang, W.; Pang, Y.; Zhu, X.; Zhou, Y.; Yan, D. Self-Assembled Micelles from an Amphiphilic Hyperbranched Copolymer with Polyphosphate Arms for Drug Delivery Langmuir 2010, 26, 10585-10592
13. 8 Star-Block Copolymers Based on PCL and PEG for Hydrophobic Drug Delivery Polymer 2011, 52, 2799-2809
14. Cao, W.; Zhu, L. Synthesis and Unimolecular Micelles of Amphiphilic Dendrimer-like Star Polymer with Various Functional Surface Groups Macromolecules 2011, 44, 1500-1512
15. Shen, Y. Q.; Zhan, Y. H.; Tang, J. B.; Xu, P. S.; Johnson, P. A.; Radosz, M.; Van Kirk, E. A.; Murdoch, W. J. Multifunctioning pH-Responsive Nanoparticles from Hierarchical Self-Assembly of Polymer Brush for Cancer Drug Delivery AIChE J. 2008, 54, 2979-2989
16. Sutton, D.; Nasongkla, N.; Blanco, E.; Gao, J. Functionalized Micellar Systems for Cancer Targeted Drug Delivery Pharm. Res. 2007, 24, 1029-1046
17. Chen, D. Q.; Song, P.; Jiang, F.; Meng, X. Y.; Sui, W. P.; Shu, C. Y.; Wan, L. J. pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment J. Phys. Chem. B 2013, 117, 1261-1268
18. Yue, Z. G.; Wei, W.; You, Z. X.; Yang, Q. Z.; Yue, H.; Su, Z. G.; Ma, G. H. Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs Adv. Funct. Mater. 2011, 21, 3446-3453
19. Giacomelli, F. C.; Stepanek, P.; Giacomelli, C.; Schmidt, V.; Jager, E.; Jager, A.; Ulbrich, K. pH-Triggered Block Copolymer Micelles Based on a pH-Responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) Inner Core and a PEO (poly(ethylene oxide)) Outer Shell as a Potential Tool for the Cancer Therapy Soft Matter 2011, 7, 9316-9325
20. Wang, W.; Cheng, D.; Gong, F.; Miao, X.; Shuai, X. Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging Adv. Mater. 2012, 24, 115-120
21. Lin, S. L.; Xu, M. Y.; Yang, Z. R. Dissipative particle dynamics study on the mesostructures of n-octadecane/water emulsion with alternating styrene-maleic acid copolymers as emulsifier Soft Matter 2012, 8, 375-384
22. Huang, X. J.; Xiao, Y.; Lang, M. Synthesis and Self-Assembly Behavior of Six-Armed Block Copolymers with pH- and Thermo-Responsive Properties Macromol. Res. 2011, 19, 113-121
23. Chen, J.; Qiu, X.; Ouyang, J.; Kong, J.; Zhong, W.; Xing, M. M. Q. pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery Biomacromolecules 2011, 12, 3601-3611
24. Zhu, W.; Nese, A.; Matyjaszewski, K. Thermoresponsive Star Triblock Copolymers by Combination of ROP and ATRP: from Micelles to Hydrogels J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 1942-1952
25. Groot, R. D.; Madden, T. J. Dynamic Simulation of Diblock Copolymer Microphase Separation J. Chem. Phys. 1998, 108, 8713-8724
26. Groot, R. D.; Madden, T. J.; Tildesley, D. J. On the Role of Hydrodynamic Interactions in Block Copolymer Microphase Separation J. Chem. Phys. 1999, 110, 9739-9749
27. Xin, J.; Liu, D.; Zhong, C. L. Multicompartment Micelles from Star and Linear Triblock Copolymer Blends J. Phys. Chem. B 2007, 111, 13675-13682
28. Rodriguez-Hidalgo, M. D. R.; Soto-Figueroa, C.; Vicente, L. Mesoscopic Simulation of the Drug Release Mechanism on the Polymeric Vehicle P(ST-DVB) in an Acid Environment Soft Matter 2011, 7, 8224-8230
29. Moeinzadeh, S.; Jabbari, E. Mesoscale Simulation of the Effect of a Lactide Segment on the Nanostructure of Star Poly (ethylene glycol- co -lactide)-Acrylate Macromonomers in Aqueous Solution J. Phys. Chem. B 2012, 116, 1536-1543
30. Guo, X. D.; Zhang, L. J.; Chen, Y.; Qian, Y. Core/Shell pH-Sensitive Micelles Self-Assembled from Cholesterol Conjugated Oligopeptides for Anticancer Drug Delivery AIChE J. 2010, 56, 1922-1931
31. Luo, Z. L.; Jiang, J. W. pH-Sensitive Drug Loading/Releasing in Amphiphilic Copolymer PAE-PEG: Integrating Molecular Dynamics and Dissipative Particle Dynamics Simulations J. Controlled Release 2012, 162, 185-193
32. Yang, Y. Q.; Lin, W. J.; Zhang, L. J.; Cai, C. Z.; Jiang, W.; Guo, X. D.; Qian, Y. Synthesis, Characterization and pH-Responsive Self-Assembly Behavior of Amphiphilic Multiarm Star Triblock Copolymers Based on PCL, PDEAEMA, and PEG Macromol. Res. 2013, 21 (9) 1011-1020
33. Hu, Y. Q.; Kim, M. S.; Kim, B. S.; Lee, D. S. RAFT Synthesis of Amphiphilic (A- ran -B)- b -C Diblock Copolymers with Tunable pH-Sensitivity J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 3740-3748
34. Liechty, W. B.; Kryscio, D. R.; Slaughter, B. V.; Peppas, N. A. Polymers for Drug Delivery Systems Annu. Rev. Chem. Biomol. 2010, 1, 149-173
35. Yang, Y. Q.; Zhao, B.; Li, Z. D.; Lin, W. J.; Zhang, C. Y.; Guo, X. D.; Wang, J. F.; Zhang, L. J. pH-Sensitive Micelles Self-Assembled from Multi-arm Star Triblock Copolymers Poly(ε-caprolactone)- b -poly(2-(diethylamino) ethyl methacrylate)- b -poly (poly(ethylene glycol) methyl ether methacrylate) for Controlled Anticancer Drug Delivery Acta Biomater. 2013, 9, 7679-7690
36. Hoogerbrugge, P. J.; Koelman, J. Simulating Microscopic Hydrodynamic Phenomena with Dissipative Particle Dynamics Europhys. Lett. 1992, 19, 155-160
37. Groot, R. D.; Warren, P. B. Dissipative Particle Dynamics: Bridging the Gap between Atomistic and Mesoscopic Simulation J. Chem. Phys. 1997, 107, 4423-4436
38. Sun, J. T.; Hong, C. Y.; Pan, C. Y. Fabrication of PDEAEMA-Coated Mesoporous Silica Nanoparticles and pH-Responsive Controlled Release J. Phys. Chem. C 2010, 114, 12481-12486
39. Wang, W. J.; Anderson, N. A.; Travesset, A.; Vaknin, D. Regulation of the Electric Charge in Phosphatidic Acid Domains J. Phys. Chem. B 2012, 116, 7213-7220
40. Yu, S. Y.; Azzam, T.; Rouiller, I.; Eisenberg, A. Breathing" Vesicles J. Am. Chem. Soc. 2009, 131, 10557-10566
41. Lecomte, F.; Siepmann, J.; Walther, M.; MacRae, R. J.; Bodmeier, R. pH-Sensitive Polymer Blends used as Coating Materials to Control Drug Release from Spherical Beads: Importance of the Type of Core Biomacromolecules 2005, 6, 2074-2083
42. Español, P.; Warren, P. Statistical Mechanics of Dissipative Particle Dynamics Europhys. Lett. 1995, 30, 191-196