Breaking the limits of artificial ubiquitination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 44, 2013, Pages 17606-17607

  Putyrski, Mateusz ^a   Dikic, Ivan ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

UBIQUITIN;

DEGENERATIVE DISEASE; HUMAN; NOTE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN MODIFICATION; UBIQUITINATION;

ALPHA-SYNUCLEIN; HUMANS; PARKINSON DISEASE; POLYUBIQUITIN; PROTEIN ENGINEERING;

EID: 84887040532     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317185110     Document Type: Note

References (15)

1. Uversky VN (2007) Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J Neurochem 103(1): 17-37.
2. Haj-Yahya M, et al. (2013) Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proc Natl Acad Sci USA 110:17726-17731.
3. Grabbe C, Husnjak K, Dikic I (2011) The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol 12(5): 295-307.
4. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479.
5. Ikeda F, Dikic I (2008) Atypical ubiquitin chains: New molecular signals. ;Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep 9(6):536-542.
6. Komander D, Rape M (2012) The ubiquitin code. Annu Rev Biochem 81:203-229.
7. Husnjak K, Dikic I (2012) Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 81:291-322.
8. McGinty RK, Kim J, Chatterjee C, Roeder RG, Muir TW (2008) Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature 453(7196):812-816.
9. Virdee S, Ye Y, Nguyen DP, Komander D, Chin JW (2010) Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nat Chem Biol 6(10): 750-757.
10. Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A (2009) Highly efficient and chemoselective peptide ubiquitylation. Angew Chem Int Ed Engl 48(43):8090-8094.
11. Virdee S, et al. (2011) Traceless and site-specific ubiquitination of recombinant proteins. J Am Chem Soc 133(28):10708-10711.
12. Hejjaoui M, Haj-Yahya M, Kumar KS, Brik A, Lashuel HA (2011) Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. Angew Chem Int Ed Engl 50(2):405-409.
13. Kumar KS, Spasser L, Erlich LA, Bavikar SN, Brik A (2010) Total chemical synthesis of di-ubiquitin chains. Angew Chem Int Ed Engl 49(48):9126-9131.
14. Bavikar SN, et al. (2012) Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases. Angew Chem Int Ed Engl 51(3): 758-763.
15. Schaefer JB, Morgan DO (2011) Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem 286(52):45186-45196.