Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Haematologica

Volumn 98, Issue 11, 2013, Pages 1797-1803

  Schimmel, Marein ^a,b   Nur, Erfan ^a,b   Biemond, Bart J ^b   van Mierlo, Gerard J ^c   Solati, Shabnam ^c   Brandjes, Dees P ^a   Otten, Hans Martin ^a   Schnog, John John ^d,e   Zeerleder, Sacha ^b,c  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d Microvida Laboratory for Medical Microbiology and Immunology   (Netherlands)

^e CENTRAL LABORATORY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; BILIRUBIN; ELASTASE; LACTATE DEHYDROGENASE; NUCLEOSOME ANTIBODY;

ACUTE CHEST SYNDROME; ADULT; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOLYSIS; HOSPITALIZATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INFLAMMATION; LABORATORY TEST; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP FORMATION; PATHOGENESIS; PROSPECTIVE STUDY; SICKLE CELL ANEMIA; THALASSEMIA;

ADULT; ANEMIA, SICKLE CELL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; NUCLEOSOMES; PAIN; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84887009674     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.088021     Document Type: Article

References (48)

1. Serjeant GR, Ceulaer CD, Lethbridge R, Morris J, Singhal A, Thomas PW. The painful crisis of homozygous sickle cell disease: clinical features. Br J Haematol. 1994; 87(3): 586-91.
2. Neonato MG, Guilloud-Bataille M, Beauvais P, Begue P, Belloy M, Benkerrou M, et al. Acute clinical events in 299 homozygous sickle cell patients living in France. French Study Group on Sickle Cell Disease. Eur J Haematol. 2000; 65(3): 155-64.
3. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, et al. Pain in sickle cell disease. Rates and risk factors. N Engl J Med. 1991; 325(1): 11-6.
4. Steinberg MH. In the clinic. Sickle cell disease. Ann Intern Med. 2011; 155(5): ITC31-15.
5. Anyaegbu CC, Okpala IE, Akren'Ova YA, Salimonu LS. Peripheral blood neutrophil count and candidacidal activity correlate with the clinical severity of sickle cell anaemia (SCA). Eur J Haematol. 1998; 60(4): 267-8.
6. Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998; 91(1): 288-94.
7. Castro O, Brambilla DJ, Thorington B, Reindorf CA, Scott RB, Gillette P, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood. 1994; 84(2): 643-9.
8. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994; 330(23): 1639-44.
9. Charache S, Barton FB, Moore RD, Terrin ML, Steinberg MH, Dover G, et al. Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive "switching" agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Medicine (Baltimore). 1996; 75(6): 300-26.
10. Almeida CB, Scheiermann C, Jang JE, Prophete C, Costa FF, Conran N, et al. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vasoocclusive events in sickle cell disease mice. Blood. 2012; 120(14): 2879-88.
11. Okpala I, Daniel Y, Haynes R, Odoemene D, Goldman J. Relationship between the clinical manifestations of sickle cell disease and the expression of adhesion molecules on white blood cells. Eur J Haematol. 2002; 69 (3): 135-44.
12. Lard LR, Mul FP, de Haas M, Roos D, Duits AJ. Neutrophil activation in sickle cell disease. J Leukoc Biol. 1999; 66(3): 411-5.
13. Fadlon E, Vordermeier S, Pearson TC, Mire-Sluis AR, Dumonde DC, Philips J, et al. Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64. Blood. 1998; 91(1): 266-74.
14. Lum AF, Wun T, Staunton D, Simon SI. Inflammatory potential of neutrophils detected in sickle cell disease. Am J Hematol. 2004; 76(2): 126-33.
15. Hofstra TC, Kalra VK, Meiselman HJ, Coates TD. Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst. Blood. 1996; 87(10): 4440-7.
16. Nur E, Biemond BJ, Otten HM, Brandjes DP, Schnog JJ. Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management. Am J Hematol. 2011; 86(6): 484-9.
17. Brittain JE, Knoll CM, Ataga KI, Orringer EP, Parise LV. Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1. Br J Haematol. 2008; 141(6): 872-81.
18. Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, Frenette PS, et al. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med. 2009; 15(4): 384-91.
19. Chang J, Shi PA, Chiang EY, Frenette PS. Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion. Blood. 2008; 111(2): 915-23.
20. Turhan A, Weiss LA, Mohandas N, Coller BS, Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci USA. 2002; 99(5): 3047-51.
21. Turhan A, Jenab P, Bruhns P, Ravetch JV, Coller BS, Frenette PS. Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes. Blood. 2004; 103(6): 2397-400.
22. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004; 303(5663): 1532-5.
23. Brinkmann V, Zychlinsky A. Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol. 2007; 5(8): 577-82.
24. Gupta AK, Joshi MB, Philippova M, Erne P, Hasler P, Hahn S, et al. Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death. FEBS Lett. 2010; 584(14): 3193-7.
25. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, et al. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009; 15(11): 1318-21.
26. Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS One. 2012; 7(2): e32366.
27. Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010; 16(8): 887-96.
28. von Bruhl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012; 209(4): 819-35.
29. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA. 2010; 107 (36): 15880-5.
30. van Montfoort ML, Stephan F, Lauw MN, Hutten BA, Van Mierlo GJ, Solati S, et al. Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2013; 33(1): 147-51.
31. Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lammle B. Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Blood. 2012; 120(6): 1157-64.
32. Amoura Z, Piette JC, Bach JF, Koutouzov S. The key role of nucleosomes in lupus. Arthritis Rheum. 1999; 42(5): 833-43.
33. Zeerleder S, Zwart B, te Velthuis H, Stephan F, Manoe R, Rensink I, et al. Nucleosomereleasing factor: a new role for factor VIIactivating protease (FSAP). FASEB J. 2008; 22(12): 4077-84.
34. Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C, et al. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med. 2003; 31(7): 1947-51.
35. Zeerleder S, Stephan F, Emonts M, de Kleijn ED, Esmon CT, Varadi K, et al. Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C. Crit Care Med. 2012; 40(12): 3224-9.
36. Chen Q, Ye L, Jin Y, Zhang N, Lou T, Qiu Z, et al. Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients. Int J Infect Dis. 2012; 16(7): e558-e64.
37. Miller AC, Gladwin MT. Pulmonary complications of sickle cell disease. Am J Respir Crit Care Med. 2012; 185(11): 1154-65.
38. Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B, et al. Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med. 2001; 29(7): 1404-7.
39. van Nieuwenhuijze AE, van Lopik T, Smeenk RJ, Aarden LA. Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus. Ann Rheum Dis. 2003; 62(1): 10-4.
40. Nuijens JH, Abbink JJ, Wachtfogel YT, Colman RW, Eerenberg AJ, Dors D, et al. Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis. J Lab Clin Med. 1992; 119(2): 159-68.
41. Ballas SK, Lewis CN, Noone AM, Krasnow SH, Kamarulzaman E, Burka ER et al. Clinical, hematological, and biochemical features of Hb SC disease. Am J Hematol. 1982; 13(1): 37-51.
42. Powars DR, Hiti A, Ramicone E, Johnson C, Chan L. Outcome in hemoglobin SC disease: a four-decade observational study of clinical, hematologic, and genetic factors. Am J Hematol. 2002; 70(3): 206-15.
43. Vasavda N, Ulug P, Kondaveeti S, Ramasamy K, Sugai T, Cheung G, et al. Circulating DNA: a potential marker of sickle cell crisis. Br J Haematol. 2007; 139(2): 331-6.
44. Ball JB, Khan SY, McLaughlin NJ, Kelher MR, Nuss R, Cole L, et al. A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils. Pediatr Blood Cancer. 2012; 58(3): 399-405.
45. Haynes J Jr, Obiako B, King JA, Hester RB, Ofori-Acquah S. Activated neutrophil-mediated sickle red blood cell adhesion to lung vascular endothelium: role of phosphatidylserine-exposed sickle red blood cells. Am J Physiol Heart Circ Physiol. 2006; 291(4): H1679-H85.
46. Savchenko AS, Inoue A, Ohashi R, Jiang S, Hasegawa G, Tanaka T, et al. Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis. Pathol Int. 2011; 61(5): 290-7.
47. Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, Moalli F, et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med. 2007; 204(4): 793-804.
48. Nur E, van Beers EJ, Martina S, Cuccovillo I, Otten HM, Schnog JJ, et al. Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisis. Blood Cells Mol Dis. 2011; 46(3): 189-94.