SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 23, 2013, Pages 7418-7429

Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

(6) Wang, Jiang a Feng, Ying a Ji, Xun a Deng, Guanghui a Leng, Ying a Liu, Hong a

a SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

4 Fluoropyrrolidine 2 carbonitrile; Dipeptidyl peptidase 4 inhibitor; Oral glucose tolerance test; Pyrrolidine 2 carbonitrile; Type 2 diabetes

Indexed keywords

1 [2 AMINO 3 PHENYLPROPANOYL] 4 FLUOROPYRROLIDINE 2 CARBONITRILE; 4 FLUOROPYRROLIDINE 2 CARBONITRILE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; PYRROLIDINE 2 CARBONITRILE DERIVATIVE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIARRHEAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; IC 50; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

MUS; RATTUS;

4-FLUOROPYRROLIDINE-2-CARBONITRILE; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; ORAL GLUCOSE TOLERANCE TEST; PYRROLIDINE-2-CARBONITRILE; TYPE 2 DIABETES;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED ICR; NITRILES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84886953802 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.09.048 Document Type: Article

Times cited : (28)

References (26)

1
- 2342466734
- S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Diabetes Care 27 2004 1047
- (2004) Diabetes Care , vol.27 , pp. 1047
- Wild, S.¹ Roglic, G.² Green, A.³ Sicree, R.⁴ King, H.⁵

2
- 33845998516
- D.J. Drucker J. Clin. Invest. 117 2007 24
- (2007) J. Clin. Invest. , vol.117 , pp. 24
- Drucker, D.J.¹

3
- 1542509792
- J.J. Meier, D. Weyhe, M. Michaely, M. Senkal, V. Zumtobel, M.A. Nauck, J.J. Holst, W.E. Schmidt, and B. Gallwitz Crit. Care Med. 32 2004 848
- (2004) Crit. Care Med. , vol.32 , pp. 848
- Meier, J.J.¹ Weyhe, D.² Michaely, M.³ Senkal, M.⁴ Zumtobel, V.⁵ Nauck, M.A.⁶ Holst, J.J.⁷ Schmidt, W.E.⁸ Gallwitz, B.⁹

4
- 0037045845
- M. Zander, S. Madsbad, J.L. Madsen, and J.J. Holst Lancet 359 2002 824
- (2002) Lancet , vol.359 , pp. 824
- Zander, M.¹ Madsbad, S.² Madsen, J.L.³ Holst, J.J.⁴

5
- 3843072211
- A.E. Weber J. Med. Chem. 47 2004 4135
- (2004) J. Med. Chem. , vol.47 , pp. 4135
- Weber, A.E.¹

6
- 34247362355
- R.E. Pratley, and A. Salsali Curr. Med. Res. Opin. 23 2007 919
- (2007) Curr. Med. Res. Opin. , vol.23 , pp. 919
- Pratley, R.E.¹ Salsali, A.²

7
- 61349143225
- S.H. Havele, and M. Pal Bioorg. Med. Chem. 17 2009 1783
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 1783
- Havele, S.H.¹ Pal, M.²

8
- 42649087085
- P.R. Flatt, C.J. Bailey, and B.D. Green Front. Biosci. 13 2008 3648
- (2008) Front. Biosci. , vol.13 , pp. 3648
- Flatt, P.R.¹ Bailey, C.J.² Green, B.D.³

9
- 19944427998
- D. Kim, L. Wang, M. Beconi, G.J. Eiermann, M.H. Fisher, H. He, G.J. Hickey, J.E. Kowalchick, B. Leiting, K. Lyons, F. Marsilio, M.E. McCann, R.A. Patel, A. Petrov, G. Scapin, S.B. Patel, R. Sinha Roy, J.K. Wu, M.J. Wyvratt, B. Zhang, L. Zhu, N.A. Thornberry, and A.E. Weber J. Med. Chem. 48 2005 141
- (2005) J. Med. Chem. , vol.48 , pp. 141
- Kim, D.¹ Wang, L.² Beconi, M.³ Eiermann, G.J.⁴ Fisher, M.H.⁵ He, H.⁶ Hickey, G.J.⁷ Kowalchick, J.E.⁸ Leiting, B.⁹ Lyons, K.¹⁰ Marsilio, F.¹¹ McCann, M.E.¹² Patel, R.A.¹³ Petrov, A.¹⁴ Scapin, G.¹⁵ Patel, S.B.¹⁶ Sinha Roy, R.¹⁷ Wu, J.K.¹⁸ Wyvratt, M.J.¹⁹ Zhang, B.²⁰ more..

10
- 33846972003
- J.F. Todd, and S.R. Bloom Diabet. Med. 24 2007 223
- (2007) Diabet. Med. , vol.24 , pp. 223
- Todd, J.F.¹ Bloom, S.R.²

11
- 39749169723
- A. Karasik, P. Aschner, H. Katzeff, M.J. Davies, and P.P. Stein Curr. Med. Res. Opin. 24 2008 489
- (2008) Curr. Med. Res. Opin. , vol.24 , pp. 489
- Karasik, A.¹ Aschner, P.² Katzeff, H.³ Davies, M.J.⁴ Stein, P.P.⁵

12
- 0037777695
- E.B. Villhauer, J.A. Brinkman, G.B. Naderi, B.F. Burkey, B.E. Dunning, K. Prasad, B.L. Mangold, M.E. Russel, and T.E. Hughes J. Med. Chem. 46 2003 2774
- (2003) J. Med. Chem. , vol.46 , pp. 2774
- Villhauer, E.B.¹ Brinkman, J.A.² Naderi, G.B.³ Burkey, B.F.⁴ Dunning, B.E.⁵ Prasad, K.⁶ Mangold, B.L.⁷ Russel, M.E.⁸ Hughes, T.E.⁹

13
- 27144460925
- B.F. Burkey, X. Li, L. Bolognese, B. Balkan, M. Mone, M. Russell, T.E. Hughes, and P.R. Wang J. Pharmacol. Exp. Ther. 315 2005 688
- (2005) J. Pharmacol. Exp. Ther. , vol.315 , pp. 688
- Burkey, B.F.¹ Li, X.² Bolognese, L.³ Balkan, B.⁴ Mone, M.⁵ Russell, M.⁶ Hughes, T.E.⁷ Wang, P.R.⁸

14
- 22744449063
- D.J. Augeri, J.A. Robl, D.A. Betebenner, D.R. Magnin, A. Khanna, J.G. Robertson, A. Wang, L.M. Simpkins, P. Taunk, Q. Huang, S.-P. Han, B. Abboa-Offei, M. Cap, L. Xin, L. Tao, E. Tozzo, G.E. Welzel, D.M. Egan, J. Marcinkeviciene, S.Y. Chang, S.A. Biller, M.S. Kirby, R.A. Parker, and L.G. Hamann J. Med. Chem. 48 2005 5025
- (2005) J. Med. Chem. , vol.48 , pp. 5025
- Augeri, D.J.¹ Robl, J.A.² Betebenner, D.A.³ Magnin, D.R.⁴ Khanna, A.⁵ Robertson, J.G.⁶ Wang, A.⁷ Simpkins, L.M.⁸ Taunk, P.⁹ Huang, Q.¹⁰ Han, S.-P.¹¹ Abboa-Offei, B.¹² Cap, M.¹³ Xin, L.¹⁴ Tao, L.¹⁵ Tozzo, E.¹⁶ Welzel, G.E.¹⁷ Egan, D.M.¹⁸ Marcinkeviciene, J.¹⁹ Chang, S.Y.²⁰ more..

15
- 34248999413
- J. Feng, Z. Zhang, M.B. Wallace, J.A. Stafford, S.W. Kaldor, D.B. Kassel, M. Navre, L. Shi, R.J. Skene, T. Asakawa, K. Takeuchi, R. Xu, D.R. Webb, and S.L. Gwaltney J. Med. Chem. 50 2007 2297
- (2007) J. Med. Chem. , vol.50 , pp. 2297
- Feng, J.¹ Zhang, Z.² Wallace, M.B.³ Stafford, J.A.⁴ Kaldor, S.W.⁵ Kassel, D.B.⁶ Navre, M.⁷ Shi, L.⁸ Skene, R.J.⁹ Asakawa, T.¹⁰ Takeuchi, K.¹¹ Xu, R.¹² Webb, D.R.¹³ Gwaltney, S.L.¹⁴

16
- 37349073397
- M. Eckhardt, E. Langkopf, M. Mark, M. Tadayyon, L. Thomas, H. Nar, W. Pfrengle, B. Guth, R. Lotz, P. Sieger, H. Fuchs, and F. Himmelsbach J. Med. Chem. 50 2007 6450
- (2007) J. Med. Chem. , vol.50 , pp. 6450
- Eckhardt, M.¹ Langkopf, E.² Mark, M.³ Tadayyon, M.⁴ Thomas, L.⁵ Nar, H.⁶ Pfrengle, W.⁷ Guth, B.⁸ Lotz, R.⁹ Sieger, P.¹⁰ Fuchs, H.¹¹ Himmelsbach, F.¹²

17
- 25844459084
- G.R. Lankas, B. Leiting, R.S. Roy, G.J. Eiermann, M.G. Beconi, T. Biftu, C.C. Chan, S. Edmondson, W.P. Feeney, H. He, D.E. Ippolito, D. Kim, K.A. Lyons, H.O. Ok, R.A. Patel, A.N. Petrov, K.A. Pryor, X. Qian, L. Reigle, A. Woods, J.K. Wu, D. Zaller, X. Zhang, L. Zhu, A.E. Weber, and N.A. Thornberry Diabetes 54 2005 2988
- (2005) Diabetes , vol.54 , pp. 2988
- Lankas, G.R.¹ Leiting, B.² Roy, R.S.³ Eiermann, G.J.⁴ Beconi, M.G.⁵ Biftu, T.⁶ Chan, C.C.⁷ Edmondson, S.⁸ Feeney, W.P.⁹ He, H.¹⁰ Ippolito, D.E.¹¹ Kim, D.¹² Lyons, K.A.¹³ Ok, H.O.¹⁴ Patel, R.A.¹⁵ Petrov, A.N.¹⁶ Pryor, K.A.¹⁷ Qian, X.¹⁸ Reigle, L.¹⁹ Woods, A.²⁰ more..

18
- 80051862999
- S. Van Goethem, V. Matheeussen, J. Joossens, A.M. Lambeir, X. Chen, I. De Meester, A. Haemers, K. Augustyns, and P. Van der Veken J. Med. Chem. 54 2011 5737
- (2011) J. Med. Chem. , vol.54 , pp. 5737
- Van Goethem, S.¹ Matheeussen, V.² Joossens, J.³ Lambeir, A.M.⁴ Chen, X.⁵ De Meester, I.⁶ Haemers, A.⁷ Augustyns, K.⁸ Van Der Veken, P.⁹

19
- 4444355871
- H.-J. Bohm, D. Banner, S. Bendels, M. Kansy, B. Kuhn, K. Müller, U. Obst-Sander, and M. Stahl Chem. Bio. Chem. 5 2004 637
- (2004) Chem. Bio. Chem. , vol.5 , pp. 637
- Bohm, H.-J.¹ Banner, D.² Bendels, S.³ Kansy, M.⁴ Kuhn, B.⁵ Müller, K.⁶ Obst-Sander, U.⁷ Stahl, M.⁸

20
- 38149070200
- S. Purser, P.R. Moore, S. Swallow, and V. Gouverneur Chem. Soc. Rev. 37 2008 320
- (2008) Chem. Soc. Rev. , vol.37 , pp. 320
- Purser, S.¹ Moore, P.R.² Swallow, S.³ Gouverneur, V.⁴

21
- 49449097238
- W.K. Hagmann J. Med. Chem. 51 2008 4359
- (2008) J. Med. Chem. , vol.51 , pp. 4359
- Hagmann, W.K.¹

22
- 33746356860
- J.-P. Beguem, and D. Bonnet-Delpon J. Fluorine Chem. 127 2006 992
- (2006) J. Fluorine Chem. , vol.127 , pp. 992
- Beguem, J.-P.¹ Bonnet-Delpon, D.²

23
- 84861183212
- K. Müller, C. Faeh, and F. Diederich Science 2007 1881 317
- (1881) Science , vol.2007 , pp. 317
- Müller, K.¹ Faeh, C.² Diederich, F.³

24
- 74849118802
- A.E. Sorochinsky, and V.A. Soloshonok J. Fluorine Chem. 131 2010 127
- (2010) J. Fluorine Chem. , vol.131 , pp. 127
- Sorochinsky, A.E.¹ Soloshonok, V.A.²

25
- 26844433886
- C.D. Haffner, D.L. McDougald, S.M. Reister, B.D. Thompson, C. Conlee, J. Fang, J. Bass, J.M. Lenhard, D. Croom, M.B. Secosky-Chang, T. Tomaszek, D. McConn, K. Wells-Knecht, and P.R. Johnson Bioorg. Med. Chem. Lett. 15 2005 5257
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5257
- Haffner, C.D.¹ McDougald, D.L.² Reister, S.M.³ Thompson, B.D.⁴ Conlee, C.⁵ Fang, J.⁶ Bass, J.⁷ Lenhard, J.M.⁸ Croom, D.⁹ Secosky-Chang, M.B.¹⁰ Tomaszek, T.¹¹ McConn, D.¹² Wells-Knecht, K.¹³ Johnson, P.R.¹⁴

26
- 79851501708
- Y. Miyamoto, Y. Banno, T. Yamashita, T. Fujimoto, S. Oi, Y. Moritoh, T. Asakawa, O. Kataoka, H. Yashiro, K. Takeuchi, N. Suzuki, K. Ikedo, T. Kosaka, S. Tsubotani, A. Tani, M. Sasaki, M. Funami, M. Amano, Y. Yamamoto, K. Aertgeerts, J. Yano, and H. Maezaki J. Med. Chem. 54 2011 831
- (2011) J. Med. Chem. , vol.54 , pp. 831
- Miyamoto, Y.¹ Banno, Y.² Yamashita, T.³ Fujimoto, T.⁴ Oi, S.⁵ Moritoh, Y.⁶ Asakawa, T.⁷ Kataoka, O.⁸ Yashiro, H.⁹ Takeuchi, K.¹⁰ Suzuki, N.¹¹ Ikedo, K.¹² Kosaka, T.¹³ Tsubotani, S.¹⁴ Tani, A.¹⁵ Sasaki, M.¹⁶ Funami, M.¹⁷ Amano, M.¹⁸ Yamamoto, Y.¹⁹ Aertgeerts, K.²⁰ Yano, J.²¹ Maezaki, H.²² more..

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.