Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4219-4223

  Bogen, S ^a   Arasappan, A ^a   Pan, W ^a   Ruan, S ^a   Padilla, A ^a   Saksena, A K ^a   Girijavallabhan, V ^a   Njoroge, F G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Fluorinated P1; HCV protease inhibitor; PK properties; SCH 503034

Indexed keywords

CILUPREVIR; HYDROXYL GROUP; N [3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL] 3 [2 (3 TERT BUTYLUREIDO) 3,3 DIMETHYL 1 OXOBUTYL] 6,6 DIMETHYL 3 AZABICYCLO[3.1.0]HEXANE 2 CARBOXAMIDE; NONSTRUCTURAL PROTEIN 3; RIBAVIRIN; SERINE PROTEINASE INHIBITOR; TELAPREVIR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; KNOEVENAGEL CONDENSATION; NONHUMAN; RAT; SHARPLESS EPOXIDATION; STRUCTURE ACTIVITY RELATION;

AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; FLUORINE; HEPATITIS C; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROLINE; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 47149114343     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.060     Document Type: Article

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