TGFβ1 microenvironment determines dendritic cell development

OncoImmunology

Volumn 2, Issue 3, 2013, Pages

  Seré, Kristin ^a,b   Felker, Piritta ^a,b   Hieronymus, Thomas ^a,b   Zenke, Martin ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cell differentiation; Dendritic cells; Id2; Langerhans cells; TGF 1

Indexed keywords

CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; EPITHELIAL CELL ADHESION MOLECULE; INHIBITOR OF DIFFERENTIATION 2; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR RUNX3; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ARTICLE; AUTOCRINE EFFECT; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FLT3 GENE; GENE INDUCTION; GENE REPRESSION; INTRACELLULAR SIGNALING; IRF4 GENE; IRF8 GENE; LANGERHANS CELL; LYMPHOID TISSUE; MIGRATION INHIBITION; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STEADY STATE; UPREGULATION;

EID: 84886944688     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.23083     Document Type: Article

References (10)

1. Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells.J Exp Med 1996; 184:2417-22; PMID:8976197; http://dx.doi.org/10.1084/jem.184.6.2417.
2. Bobr A, Igyarto BZ, Haley KM, Li MO, Flavell RA, Kaplan DH. Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration.Proc Natl Acad Sci U S A 2012; 109:10492-7; PMID:22689996; http://dx.doi.org/10.1073/pnas.1119178109.
3. Kel JM, Girard-Madoux MJ, Reizis B, Clausen BE. TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis.J Immunol 2010; 185:3248-55; PMID:20713882; http://dx.doi.org/10.4049/jimmunol.1000981.
4. Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, et al.Transcriptional profiling identifies Id2 function in dendritic cell development.Nat Immunol 2003; 4:380-6; PMID:12598895; http://dx.doi.org/10.1038/ni903.
5. Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.Nat Rev Immunol 2008; 8:935-47; PMID:19029989; http://dx.doi.org/10.1038/nri2455.
6. Seré K, Baek JH, Ober-Blöbaum J, Müller-Newen G, Tacke F, Yokota Y, et al.Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation.Immunity 2012; 37:905-16; PMID:23159228; http://dx.doi.org/10.1016/j.immuni.2012.07.019.
7. Chorro L, Sarde A, Li M, Woollard KJ, Chambon P, Malissen B, et al.Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.J Exp Med 2009; 206:3089-100; PMID:19995948; http://dx.doi.org/10.1084/jem.20091586.
8. Strobl H, Knapp W. TGF-beta1 regulation of dendritic cells. Microbes Infect 1999; 1:1283-90; PMID:10611756; http://dx.doi.org/10.1016/S1286-4579(99)00256-7.
9. Seré KM, Lin Q, Felker P, Rehage N, Klisch T, Ortseifer I, et al.Dendritic cell lineage commitment is instructed by distinct cytokine signals. Eur J Cell Biol 2012; 91:515-23; PMID:22078373; http://dx.doi.org/10.1016/j.ejcb.2011.09.007.
10. Felker P, Seré K, Lin Q, Becker C, Hristov M, Hieronymus T, et al.TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.J Immunol 2010; 185:5326-35; PMID:20881193; http://dx.doi.org/10.4049/jimmunol.0903950.