Methylisothiazolinone is categorised as a strong sensitiser in the Murine Local Lymph Node Assay

Contact Dermatitis

Volumn 69, Issue 5, 2013, Pages 261-262

  Roberts, David W ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE;

EDITORIAL; LOCAL LYMPH NODE ASSAY;

EID: 84886886141     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/cod.12167     Document Type: Editorial

References (9)

1. Lundov M D, Krongaard T, Menné T L, Johansen J D,. Methylisothiazolinone contact allergy a review. Br J Dermatol 2011: 165: 1178-1182.
2. Geier J, Lessman H, Schnuch A, Uter W,. Recent increase in allergic reactions to methylchloroisothiazolinone/methylisothiazolinone: is methylisothiazolinone the culprit? Contact Dermatitis 2012: 67: 334-341.
3. Alvarez-Sánchez R, Basketter D, Pease C, Lepoittevin J-P,. Studies of chemical selectivity of hapten, reactivity, and skin sensitization. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitisers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI). Chem Res Toxicol 2003: 16: 627-636.
4. Aptula A O, Roberts D W, Cronin M T D,. From experiment to theory: molecular orbital parameters to interpret the skin sensitization potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol 2005: 18: 324-329.
5. Natsch A, Haupt T, Laue H,. Relating skin sensitizing potency to chemical reactivity: reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than S(N)Ar- and S(N)2- reactive chemicals. Chem Res Toxicol 2011: 24: 2018-2027.
6. Roberts D W, Patlewicz G, Kern P S, et al. Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol 2007: 20: 1019-1030.
7. Gerberick G F, Ryan C A, Kern P S, et al. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005: 16: 157-202.
8. Basketter D A, Gilmoour N J, Wright Z, et al. Biocides: characterization of the allergenic hazard of methylisothiazolinone. Cutan Ocul Toxicol 2003: 22: 187-199.
9. Estrada E, Patlewicz G, Chamberlain M, et al. Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach. Chem Res Toxicol 2003: 16: 1226-1235.