Compound heterozygosity of the functionally null Cdh23v-ngt and hypomorphic Cdh23ahl alleles leads to early-onset progressive hearing loss in mice

Experimental Animals

Volumn 62, Issue 4, 2013, Pages 333-346

  Miyasaka, Yuki ^a,b   Suzuki, Sari ^a,c   Ohshiba, Yasuhiro ^a,b   Watanabe, Kei ^a,d   Sagara, Yoshihiko ^c,e   Yasuda, Shumpei P ^a   Matsuoka, Kunie ^a   Shitara, Hiroshi ^a   Yonekawa, Hiromichi ^a   Kominami, Ryo ^b   Kikkawa, Yoshiaki ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e RIKEN BIORESOURCE CENTER   (Japan)

Author keywords

Age related hearing loss; Cadherin 23; Hair cell; Mouse mutant; Stereocilia

Indexed keywords

CADHERIN 23;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY EQUILIBRIUM; CDH23 GENE; CELL DEGENERATION; COCHLEA; CONTROLLED STUDY; DISEASE COURSE; EVOKED BRAIN STEM AUDITORY RESPONSE; EXPERIMENTAL MOUSE; FEMALE; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAIR CELL; HEARING IMPAIRMENT; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MORPHOGENESIS; MOUSE; NONHUMAN; NULL ALLELE; ONSET AGE; PHENOTYPE; SIGNAL TRANSDUCTION; STEREOCILIUM;

AGING; ALLELES; ANIMALS; CADHERINS; DISEASE PROGRESSION; GENE DOSAGE; HEARING LOSS; HETEROZYGOTE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; NERVE DEGENERATION; STEREOCILIA;

EID: 84886866180     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.62.333     Document Type: Article

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