Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade

British Journal of Pharmacology

Volumn 170, Issue 6, 2013, Pages 1190-1198

  Lau, Yeh Siang ^a   Tian, Xiao Yu ^b   Mustafa, Mohd Rais ^a   Murugan, Dharmani ^a   Liu, Jian ^b   Zhang, Yang ^b   Lau, Chi Wai ^b   Huang, Yu ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

boldine; diabetic mice; endothelial dysfunction; oxidative stress

Indexed keywords

3 NITROTYROSINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BOLDINE; BONE MORPHOGENETIC PROTEIN 4; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; LOSARTAN; NOGGIN; REACTIVE OXYGEN METABOLITE; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ASSAY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

BOLDINE; DIABETIC MICE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;

ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; APORPHINES; BONE MORPHOGENETIC PROTEIN 4; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RECEPTOR, ANGIOTENSIN, TYPE 1; VASODILATION;

EID: 84886791026     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12350     Document Type: Article

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