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Volumn 69, Issue 11, 2013, Pages 1901-1907

An acenocoumarol dose algorithm based on a South-Eastern European population

Author keywords

Acenocoumarol; Algorithm; CYP2C9; VKORC1

Indexed keywords

ACENOCOUMAROL; CYTOCHROME P450 2C9;

EID: 84886777993     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-013-1551-3     Document Type: Article
Times cited : (16)

References (33)
  • 1
    • 2042449764 scopus 로고    scopus 로고
    • CYP2C9 and oral anticoagulation therapy with acenocoumarol and warfarin: Similarities yet differences
    • 10.1016/j.clpt.2004.01.007 15116049 10.1016/j.clpt.2004.01.007 1:CAS:528:DC%2BD2cXjs1CjtLg%3D
    • Takahashi H, Wilkinson GR, Padrini R, Echizen H (2004) CYP2C9 and oral anticoagulation therapy with acenocoumarol and warfarin: similarities yet differences. Clin Pharmacol Ther 75(5):376-380. doi: 10.1016/j.clpt.2004.01.007
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.5 , pp. 376-380
    • Takahashi, H.1    Wilkinson, G.R.2    Padrini, R.3    Echizen, H.4
  • 2
    • 70149110672 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 enzymes and its clinical impact
    • 10.1080/03602530902843483 19514967 10.1080/03602530902843483 1:CAS:528:DC%2BD1MXnsVags78%3D
    • Zhou SF, Liu JP, Chowbay B (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 41(2):89-295. doi: 10.1080/03602530902843483
    • (2009) Drug Metab Rev , vol.41 , Issue.2 , pp. 89-295
    • Zhou, S.F.1    Liu, J.P.2    Chowbay, B.3
  • 3
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Physicians evidence-based clinical practice guidelines
    • 10.1378/chest.11-2292 22315269 10.1378/chest.11-2292 1:CAS:528: DC%2BC38XnsVOrt7Y%3D
    • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G (2012) Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 141[2 Suppl]:e44S-e88S. doi: 10.1378/chest.11-2292
    • (2012) Chest , vol.141 , Issue.2 SUPPL.
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3    Crowther, M.4    Hylek, E.M.5    Palareti, G.6
  • 4
    • 84871026770 scopus 로고    scopus 로고
    • Analysis of CYP2C9*2, CYP2C9*3 and VKORC1-1639 G > A polymorphisms in a population from South-Eastern Europe
    • 10.1111/j.1582-4934.2012.01606.x 22863573 10.1111/j.1582-4934.2012.01606. x 1:CAS:528:DC%2BC3sXjt1Wjs7o%3D
    • Buzoianu AD, Trifa AP, Mureşanu DF, Crişan S (2012) Analysis of CYP2C9*2, CYP2C9*3 and VKORC1-1639 G > A polymorphisms in a population from South-Eastern Europe. J Cell Mol Med 16(12):2919-2924. doi: 10.1111/j.1582-4934.2012.01606.x
    • (2012) J Cell Mol Med , vol.16 , Issue.12 , pp. 2919-2924
    • Buzoianu, A.D.1    Trifa, A.P.2    Mureşanu, D.F.3    Crişan, S.4
  • 5
    • 34247141066 scopus 로고    scopus 로고
    • Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - Rationale and perspectives
    • 10.1016/j.thromres.2006.10.021 10.1016/j.thromres.2006.10.021 1:CAS:528:DC%2BD2sXksFeju70%3D
    • Yin T, Miyata T (2007) Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives. Thrombosis Res 120(1):1-10. doi: 10.1016/j.thromres.2006.10.021
    • (2007) Thrombosis Res , vol.120 , Issue.1 , pp. 1-10
    • Yin, T.1    Miyata, T.2
  • 6
    • 0028210729 scopus 로고
    • Impaired S-warfarin metabolism catalyzed by R144C allelic variant of CYP2C9
    • 8004131 10.1097/00008571-199402000-00005 1:CAS:528:DyaK2cXlvFCrsL0%3D
    • Rettie AE, Wienkers LC, Gonzalez FJ, Trager WF, Korzekwa KR (1994) Impaired S-warfarin metabolism catalyzed by R144C allelic variant of CYP2C9. Pharmacogenetics 4:39-42
    • (1994) Pharmacogenetics , vol.4 , pp. 39-42
    • Rettie, A.E.1    Wienkers, L.C.2    Gonzalez, F.J.3    Trager, W.F.4    Korzekwa, K.R.5
  • 7
    • 0030858832 scopus 로고    scopus 로고
    • The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase
    • 9241660 10.1097/00008571-199706000-00005 1:CAS:528:DyaK2sXkvFymtLY%3D
    • Crespi CL, Miller VP (1997) The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase. Pharmacogenetics 7:203-210
    • (1997) Pharmacogenetics , vol.7 , pp. 203-210
    • Crespi, C.L.1    Miller, V.P.2
  • 8
    • 33745411452 scopus 로고    scopus 로고
    • VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: Interaction between both genotypes affects overanticoagulation
    • 10.1016/j.clpt.2006.04.006 16815313 10.1016/j.clpt.2006.04.006 1:CAS:528:DC%2BD28Xms1enu7w%3D
    • Schalekamp T, Brassé BP, Roijers JFM, Chahid Y, van Geest-Daalderop JHH et al (2006) VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: Interaction between both genotypes affects overanticoagulation. Clin Pharmacol Ther 80(1):13-22. doi: 10.1016/j.clpt.2006. 04.006
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.1 , pp. 13-22
    • Schalekamp, T.1    Brassé, B.P.2    Roijers, J.F.M.3    Chahid, Y.4    Van Geest-Daalderop, J.H.H.5
  • 9
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
    • 10.1001/jama.287.13.1690 11926893 10.1001/jama.287.13.1690 1:CAS:528:DC%2BD38XisFaru7c%3D
    • Higashi MK, Veenstra DL, Kondo LM, Wittkowsky AK, Srinouanprachanh SL, Farin FM et al (2002) Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 287(13):1690-1698. doi: 10.1001/jama.287.13.1690
    • (2002) JAMA , vol.287 , Issue.13 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3    Wittkowsky, A.K.4    Srinouanprachanh, S.L.5    Farin, F.M.6
  • 10
    • 0842269293 scopus 로고    scopus 로고
    • The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon
    • 15128048 10.1097/00008571-200401000-00003 1:CAS:528:DC%2BD2cXjs1agsL8%3D
    • Visser LE, van Vliet M, van Schaik RH, Kasbergen AA, De Smet PA, Vulto AG et al (2004) The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. Pharmacogenetics 14(1):27-33
    • (2004) Pharmacogenetics , vol.14 , Issue.1 , pp. 27-33
    • Visser, L.E.1    Van Vliet, M.2    Van Schaik, R.H.3    Kasbergen, A.A.4    De Smet, P.A.5    Vulto, A.G.6
  • 11
    • 77951931834 scopus 로고    scopus 로고
    • Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements
    • 10.1007/s00228-009-0768-7 20020283 10.1007/s00228-009-0768-7 1:CAS:528:DC%2BC3cXitVOgsbY%3D
    • Cadamuro J, Dieplinger B, Felder T, Kedenko I, Mueller T, Haltmayer M et al (2010) Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. Eur J Clin Pharmacol 66(3):253-260. doi: 10.1007/s00228-009- 0768-7
    • (2010) Eur J Clin Pharmacol , vol.66 , Issue.3 , pp. 253-260
    • Cadamuro, J.1    Dieplinger, B.2    Felder, T.3    Kedenko, I.4    Mueller, T.5    Haltmayer, M.6
  • 12
    • 3242786500 scopus 로고    scopus 로고
    • Vitamin K epoxide reductase: Homology, active site and catalytic mechanism
    • 10.1016/j.tibs.2004.04.004 15276181 10.1016/j.tibs.2004.04.004 1:CAS:528:DC%2BD2cXlsFentLs%3D
    • Goodstadt L, Ponting CP (2004) Vitamin K epoxide reductase: homology, active site and catalytic mechanism. Trends Biochem Sci 29(6):289-292. doi: 10.1016/j.tibs.2004.04.004
    • (2004) Trends Biochem Sci , vol.29 , Issue.6 , pp. 289-292
    • Goodstadt, L.1    Ponting, C.P.2
  • 13
    • 31344451857 scopus 로고    scopus 로고
    • Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
    • 10.1097/01.fpc.0000184955.08453.a8 16424822 10.1097/01.fpc.0000184955. 08453.a8 1:CAS:528:DC%2BD28Xls1Gksg%3D%3D
    • Takahashi H, Wilkinson GR, Nutescu EA, Morita T, Ritchie MD, Scordo MG et al (2006) Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. Pharmacogenet Genomics 16(2):101-110. doi: 10.1097/01.fpc.0000184955.08453.a8
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.2 , pp. 101-110
    • Takahashi, H.1    Wilkinson, G.R.2    Nutescu, E.A.3    Morita, T.4    Ritchie, M.D.5    Scordo, M.G.6
  • 14
    • 33645055377 scopus 로고    scopus 로고
    • The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients
    • 10.1111/j.1365-2141.2006.06007.x 16611310 10.1111/j.1365-2141.2006.06007. x 1:CAS:528:DC%2BD28Xltlaqs70%3D
    • Montes R, Ruiz de Gaona E, Martínez-González MA, Alberca I, Hermida J (2006) The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Br J Haematol 133(2):183-187. doi: 10.1111/j.1365-2141.2006.06007.x
    • (2006) Br J Haematol , vol.133 , Issue.2 , pp. 183-187
    • Montes, R.1    Ruiz De Gaona, E.2    Martínez-González, M.A.3    Alberca, I.4    Hermida, J.5
  • 15
    • 0031018558 scopus 로고    scopus 로고
    • Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy
    • 10.7326/0003-4819-126-2-199701150-00006 9005747 10.7326/0003-4819-126-2- 199701150-00006 1:CAS:528:DyaK2sXpt1ensA%3D%3D
    • Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J (1997) Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med 126(2):133-136. doi: 10.7326/0003-4819-126-2-199701150- 00006
    • (1997) Ann Intern Med , vol.126 , Issue.2 , pp. 133-136
    • Harrison, L.1    Johnston, M.2    Massicotte, M.P.3    Crowther, M.4    Moffat, K.5    Hirsh, J.6
  • 16
    • 0038750759 scopus 로고    scopus 로고
    • Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial
    • 12729425 10.7326/0003-4819-138-9-200305060-00007 1:CAS:528: DC%2BD3sXktVyhsLY%3D
    • Kovacs MJ, Rodger M, Anderson DR, Morrow B, Kells G, Kovacs J et al (2003) Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial. Ann Intern Med 138(9):714-719
    • (2003) Ann Intern Med , vol.138 , Issue.9 , pp. 714-719
    • Kovacs, M.J.1    Rodger, M.2    Anderson, D.R.3    Morrow, B.4    Kells, G.5    Kovacs, J.6
  • 17
    • 3042575861 scopus 로고    scopus 로고
    • Warfarin dosing and cytochrome P450 2C9 polymorphisms
    • 10.1160/TH04-02-0083 15175798 1:CAS:528:DC%2BD2cXltF2jsr4%3D
    • Joffe HV, Xu R, Johnson FB, Longtine J, Kucher N, Goldhaber SZ (2004) Warfarin dosing and cytochrome P450 2C9 polymorphisms. Thromb Haemost 91(6):1123-1128. doi: 10.1160/TH04-02-0083
    • (2004) Thromb Haemost , vol.91 , Issue.6 , pp. 1123-1128
    • Joffe, H.V.1    Xu, R.2    Johnson, F.B.3    Longtine, J.4    Kucher, N.5    Goldhaber, S.Z.6
  • 18
    • 39149092661 scopus 로고    scopus 로고
    • Pharmacogenetics: Data, concepts and tools to improve drug discovery and drug treatment
    • 10.1007/s00228-007-0424-z 18224312 10.1007/s00228-007-0424-z
    • Brockmöller J, Tzvetkov MT (2008) Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. Eur J Clin Pharmacol 64(2):133-157. doi: 10.1007/s00228-007-0424-z
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.2 , pp. 133-157
    • Brockmöller, J.1    Tzvetkov, M.T.2
  • 19
    • 49549107264 scopus 로고    scopus 로고
    • Pharmacogenetics of oral anticoagulants: A basis for dose individualization
    • 10.2165/00003088-200847090-00002 18698879 10.2165/00003088-200847090- 00002 1:CAS:528:DC%2BD1cXhtFylsbjP
    • Stehle S, Kirchheiner J, Lazar A, Fuhr U (2008) Pharmacogenetics of oral anticoagulants: a basis for dose individualization. Clin Pharmacokinet 47(9):565-594. doi: 10.2165/00003088-200847090-00002
    • (2008) Clin Pharmacokinet , vol.47 , Issue.9 , pp. 565-594
    • Stehle, S.1    Kirchheiner, J.2    Lazar, A.3    Fuhr, U.4
  • 20
    • 84864103206 scopus 로고    scopus 로고
    • An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in spanish patients with thromboembolic disease
    • 10.1371/journal.pone.0041360 22911785 10.1371/journal.pone.0041360 1:CAS:528:DC%2BC38XhtFSkt77E
    • Borobia AM, Lubomirov R, Ramírez E, Lorenzo A, Campos A, Muñoz-Romo R et al (2012) An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in spanish patients with thromboembolic disease. PLoS One 7(7):e41360. doi: 10.1371/journal.pone.0041360
    • (2012) PLoS One , vol.7 , Issue.7 , pp. 41360
    • Borobia, A.M.1    Lubomirov, R.2    Ramírez, E.3    Lorenzo, A.4    Campos, A.5    Muñoz-Romo, R.6
  • 21
    • 77955293789 scopus 로고    scopus 로고
    • A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants
    • 10.1371/journal.pone.0011210 20585445 10.1371/journal.pone.0011210
    • Verde Z, Ruiz JR, Santiago C, Valle B, Bandrés F et al (2010) A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants. PLoS One 5(6):e11210. doi: 10.1371/journal.pone. 0011210
    • (2010) PLoS One , vol.5 , Issue.6 , pp. 11210
    • Verde, Z.1    Ruiz, J.R.2    Santiago, C.3    Valle, B.4    Bandrés, F.5
  • 22
    • 80051512500 scopus 로고    scopus 로고
    • Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data
    • 10.1093/eurheartj/ehr116 21636598 10.1093/eurheartj/ehr116
    • van Schie RMF, Wessels JAM, le Cessie S, de Boer A, Schalekamp T, van der Meer FJM et al (2011) Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data. Eur Heart J 32(15):1909-1917. doi: 10.1093/eurheartj/ehr116
    • (2011) Eur Heart J , vol.32 , Issue.15 , pp. 1909-1917
    • Van Schie, R.M.F.1    Wessels, J.A.M.2    Le Cessie, S.3    De Boer, A.4    Schalekamp, T.5    Van Der Meer, F.J.M.6
  • 23
    • 0032819729 scopus 로고    scopus 로고
    • Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin
    • 10.1046/j.1365-2125.1999.00012.x 10510154 10.1046/j.1365-2125.1999.00012. x 1:CAS:528:DyaK1MXmsFehsLg%3D
    • Aynacioglu AS, Brockmöller J, Bauer S, Sachse C, Güzelbey P, Ongen Z et al (1999) Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin. Br J Clin Pharmacol 48(3):409-415. doi: 10.1046/j.1365-2125.1999.00012.x
    • (1999) Br J Clin Pharmacol , vol.48 , Issue.3 , pp. 409-415
    • Aynacioglu, A.S.1    Brockmöller, J.2    Bauer, S.3    Sachse, C.4    Güzelbey, P.5    Ongen, Z.6
  • 24
    • 42549147841 scopus 로고    scopus 로고
    • Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes
    • 10.1038/sj.clpt.6100453 18183038 10.1038/sj.clpt.6100453 1:CAS:528:DC%2BD1cXnt1KqsL4%3D
    • Wen MS, Lee M, Chen JJ, Chuang HP, Lu LS, Chen CH et al (2008) Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes. Clin Pharmacol Ther 84(1):83-89. doi: 10.1038/sj.clpt.6100453
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.1 , pp. 83-89
    • Wen, M.S.1    Lee, M.2    Chen, J.J.3    Chuang, H.P.4    Lu, L.S.5    Chen, C.H.6
  • 25
    • 0021161772 scopus 로고
    • Effect of age and sex on acenocoumarol requirements
    • 6487488 10.1111/j.1365-2125.1984.tb02494.x 1:STN:280: DyaL2M%2FitlSqsw%3D%3D
    • Arboix M, Laporte JR, Frati ME, Rutllan M (1984) Effect of age and sex on acenocoumarol requirements. Br J Clin Pharmacol 18(4):475-479
    • (1984) Br J Clin Pharmacol , vol.18 , Issue.4 , pp. 475-479
    • Arboix, M.1    Laporte, J.R.2    Frati, M.E.3    Rutllan, M.4
  • 26
    • 0023801158 scopus 로고
    • Drug metabolism in the elderly
    • 10.1016/0163-7258(88)90115-5 3277208 10.1016/0163-7258(88)90115-5 1:CAS:528:DyaL1cXhtVGktr0%3D
    • Loi CM, Vestal RE (1988) Drug metabolism in the elderly. Pharmacol Ther 36:131-149. doi: 10.1016/0163-7258(88)90115-5
    • (1988) Pharmacol Ther , vol.36 , pp. 131-149
    • Loi, C.M.1    Vestal, R.E.2
  • 27
    • 0031783832 scopus 로고    scopus 로고
    • In vivo age-related changes in hepatic drug-oxidizing capacity in humans
    • 9867310 10.1046/j.1365-2710.1998.00164.x 1:CAS:528:DyaK1MXhsVyjsg%3D%3D
    • Tanaka E (1998) In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther 23(4):247-255
    • (1998) J Clin Pharm Ther , vol.23 , Issue.4 , pp. 247-255
    • Tanaka, E.1
  • 28
    • 51049095076 scopus 로고    scopus 로고
    • The effect of chronic renal failure on drug metabolism and transport
    • 10.1517/17425255.4.8.1065 18680441 10.1517/17425255.4.8.1065 1:CAS:528:DC%2BD1cXpsVGisLk%3D
    • Dreisbach AW, Lertora JJ (2008) The effect of chronic renal failure on drug metabolism and transport. Expert Opin Drug Metab Toxicol 4(8):1065-1074. doi: 10.1517/17425255.4.8.1065
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.8 , pp. 1065-1074
    • Dreisbach, A.W.1    Lertora, J.J.2
  • 29
    • 0017714172 scopus 로고
    • The influence of age on the response to anticoagulants
    • 911605 10.1111/j.1365-2125.1977.tb00786.x 1:STN:280: DyaE1c%2FitVGmsw%3D%3D
    • Husted S, Andreasen F (1977) The influence of age on the response to anticoagulants. Br J Clin Pharmacol 4:559-565
    • (1977) Br J Clin Pharmacol , vol.4 , pp. 559-565
    • Husted, S.1    Andreasen, F.2
  • 30
    • 79954423810 scopus 로고    scopus 로고
    • Proton pump inhibitors and the risk of overanticoagulation during acenocoumarol maintenance treatment
    • 10.1111/j.1365-2141.2011.08633.x 21418179 10.1111/j.1365-2141.2011.08633. x
    • Teichert M, van Noord C, Uitterlinden AG, Hofman A, Buhre PN, De Smet PA et al (2011) Proton pump inhibitors and the risk of overanticoagulation during acenocoumarol maintenance treatment. Br J Haematol 153(3):379-385. doi: 10.1111/j.1365-2141.2011.08633.x
    • (2011) Br J Haematol , vol.153 , Issue.3 , pp. 379-385
    • Teichert, M.1    Van Noord, C.2    Uitterlinden, A.G.3    Hofman, A.4    Buhre, P.N.5    De Smet, P.A.6
  • 31
    • 0030754399 scopus 로고    scopus 로고
    • Lack of effect of omeprazole in oral acenocoumarol anticoagulant therapy
    • 10.3109/00365529709011215 9361171 10.3109/00365529709011215 1:CAS:528:DyaK2sXmslOrt7o%3D
    • Vreeburg EM, De Vlaam-Schluter GM, Trienekens PH, Snel P, Tytgat GN (1997) Lack of effect of omeprazole in oral acenocoumarol anticoagulant therapy. Scand J Gastroenterol 32(10):991-994. doi: 10.3109/00365529709011215
    • (1997) Scand J Gastroenterol , vol.32 , Issue.10 , pp. 991-994
    • Vreeburg, E.M.1    De Vlaam-Schluter, G.M.2    Trienekens, P.H.3    Snel, P.4    Tytgat, G.N.5
  • 32
    • 0030769017 scopus 로고    scopus 로고
    • No effect of short-term omeprazole intake on acenocoumarol pharmacokinetics and pharmacodynamics
    • 10.1046/j.1365-2125.1997.00600.x 9354316 10.1046/j.1365-2125.1997.00600.x
    • de Hoon JN, Thijssen HH, Beysens AJ, Van Bortel LM (1997) No effect of short-term omeprazole intake on acenocoumarol pharmacokinetics and pharmacodynamics. Br J Clin Pharmacol 44(4):399-401. doi: 10.1046/j.1365-2125. 1997.00600.x
    • (1997) Br J Clin Pharmacol , vol.44 , Issue.4 , pp. 399-401
    • De Hoon, J.N.1    Thijssen, H.H.2    Beysens, A.J.3    Van Bortel, L.M.4
  • 33
    • 84878003354 scopus 로고    scopus 로고
    • Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose
    • 10.1515/dmdi-2012-0024 23096528
    • van Schie RM, Verhoef TI, Boejharat SB, Schalekamp T, Wessels JA, le Cessie S et al (2012) Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose. Drug Metabol Drug Interact 27(4):229-234. doi: 10.1515/dmdi-2012-0024
    • (2012) Drug Metabol Drug Interact , vol.27 , Issue.4 , pp. 229-234
    • Van Schie, R.M.1    Verhoef, T.I.2    Boejharat, S.B.3    Schalekamp, T.4    Wessels, J.A.5    Le Cessie, S.6


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