Bone formation around zirconia implants combined with rhBMP-2 gel in the canine mandible

Clinical Oral Implants Research

Volumn 24, Issue 12, 2013, Pages 1332-1338

  Lee, Byung Chul ^a   Yeo, In Sung ^a   Kim, Dae Joon ^b   Lee, Jai Bong ^a   Kim, Sung Hun ^a   Han, Jung Suk ^a  

^a Seoul National University   (South Korea)

^b Sejong University   (South Korea)

Author keywords

Alumina toughened zirconia; Bone morphogenetic protein 2; Bone response; Canine model; Zirconia implant

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TITANIUM; TRANSFORMING GROWTH FACTOR BETA; ZIRCONIUM; ZIRCONIUM OXIDE;

ALUMINA-TOUGHENED ZIRCONIA; ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; BONE RESPONSE; CANINE MODEL; CHEMISTRY; DOG; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GEL; IMPLANT; MANDIBLE; SURFACE PROPERTY; TOOTH IMPLANT; ZIRCONIA IMPLANT;

ALUMINA-TOUGHENED ZIRCONIA; BONE MORPHOGENETIC PROTEIN-2; BONE RESPONSE; CANINE MODEL; ZIRCONIA IMPLANT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DENTAL IMPLANTS; DOGS; GELS; IMPLANTS, EXPERIMENTAL; MANDIBLE; MICROSCOPY, FLUORESCENCE; OSSEOINTEGRATION; OSTEOGENESIS; RECOMBINANT PROTEINS; SURFACE PROPERTIES; TITANIUM; TRANSFORMING GROWTH FACTOR BETA; ZIRCONIUM;

EID: 84886751824     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/clr.12004     Document Type: Article

References (35)

1. Akagawa, Y., Hosokawa, R., Sato, Y. & Kamayama, K. (1998) Comparison between freestanding and tooth-connected partially stabilized zirconia implants after two years' function in monkeys: a clinical and histologic study. Journal of Prosthetic Dentistry 80: 551-558.
2. Akagawa, Y., Ichikawa, Y., Nikai, H. & Tsuru, H. (1993) Interface histology of unloaded and early loaded partially stabilized zirconia endosseous implant in initial bone healing. Journal of Prosthetic Dentistry 69: 599-604.
3. Andreiotelli, M. & Kohal, R.J. (2009) Fracture strength of zirconia implants after artificial aging. Clinical Implant Dentistry and Related Research 11: 158-166.
4. Andreiotelli, M., Wenz, H.J. & Kohal, R.J. (2009) Are ceramic implants a viable alternative to titanium implants? A systematic literature review Clinical Oral Implants Research 20(Suppl. 4): 32-47.
5. Becker, J., Kirsch, A., Schwarz, F., Chatzinikolaidou, M., Rothamel, D., Lekovic, V., Laub, M. & Jennissen, H.P. (2006) Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhbmp-2). A pilot study in dogs. Clinical Oral Investigations 10: 217-224.
6. Bessho, K., Carnes, D.L., Cavin, R., Chen, H.Y. & Ong, J.L. (1999) Bmp stimulation of bone response adjacent to titanium implants in vivo. Clinical Oral Implants Research 10: 212-218.
7. Brunner, E., Domhof, S. & Langer, F. (2002) Nonparametric analysis of longitudinal data in factorial experiments, New York, NY: Wiley.
8. Depprich, R., Zipprich, H., Ommerborn, M., Naujoks, C., Wiesmann, H.P., Kiattavorncharoen, S., Lauer, H.C., Meyer, U., Kubler, N.R. & Handschel, J. (2008) Osseointegration of zirconia implants compared with titanium: an in vivo study. Head & Face Medicine 4: 30.
9. Dubruille, J.H., Viguier, E., Le Naour, G., Dubruille, M.T., Auriol, M. & Le Charpentier, Y. (1999) Evaluation of combinations of titanium, zirconia, and alumina implants with 2 bone fillers in the dog. International Journal of Oral and Maxillofacial Implants 14: 271-277.
10. Gahlert, M., Gudehus, T., Eichhorn, S., Steinhauser, E., Kniha, H. & Erhardt, W. (2007) Biomechanical and histomorphometric comparison between zirconia implants with varying surface textures and a titanium implant in the maxilla of miniature pigs. Clinical Oral Implants Research 18: 662-668.
11. Koch, F.P., Weng, D., Kramer, S., Biesterfeld, S., Jahn-Eimermacher, A. & Wagner, W. (2010) Osseointegration of one-piece zirconia implants compared with a titanium implant of identical design: a histomorphometric study in the dog. Clinical Oral Implants Research 21: 350-356.
12. Kohal, R.J., Weng, D., Bachle, M. & Strub, J.R. (2004) Loaded custom-made zirconia and titanium implants show similar osseointegration: an animal experiment. Journal of Periodontology 75: 1262-1268.
13. Koide, M., Murase, Y., Yamato, K., Noguchi, T., Okahashi, N. & Nishihara, T. (1999) Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2. Biochemical and Biophysical Research Communications 259: 97-102.
14. Lalor, P.A., Revell, P.A., Gray, A.B., Wright, S., Railton, G.T. & Freeman, M.A. (1991) Sensitivity to titanium. A cause of implant failure?. Journal of Bone and Joint Surgery. British Volume 73: 25-28.
15. Langhoff, J.D., Voelter, K., Scharnweber, D., Schnabelrauch, M., Schlottig, F., Hefti, T., Kalchofner, K., Nuss, K. & von Rechenberg, B. (2008) Comparison of chemically and pharmaceutically modified titanium and zirconia implant surfaces in dentistry: a study in sheep. International Journal of Oral and Maxillofacial Surgery 37: 1125-1132.
16. Lee, J., Sieweke, J.H., Rodriguez, N.A., Schupbach, P., Lindstrom, H., Susin, C. & Wikesjo, U.M. (2009) Evaluation of nano-technology-modified zirconia oral implants: a study in rabbits. Journal of Clinical Periodontology 36: 610-617.
17. Leknes, K.N., Yang, J., Qahash, M., Polimeni, G., Susin, C. & Wikesjo, U.M. (2008) Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: radiographic observations. Clinical Oral Implants Research 19: 1027-1033.
18. Liu, Y., Enggist, L., Kuffer, A.F., Buser, D. & Hunziker, E.B. (2007) The influence of bmp-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration. Biomaterials 28: 2677-2686.
19. Matin, K., Senpuku, H., Hanada, N., Ozawa, H. & Ejiri, S. (2003) Bone regeneration by recombinant human bone morphogenetic protein-2 around immediate implants: a pilot study in rats. International Journal of Oral and Maxillofacial Implants 18: 211-217.
20. Pirker, W., Wiedemann, D., Lidauer, A. & Kocher, A.A. (2011) Immediate, single stage, truly anatomic zirconia implant in lower molar replacement: a case report with 2.5 years follow-up. International Journal of Oral and Maxillofacial Surgery 40: 212-216.
21. Reddi, A.H. & Cunningham, N.S. (1993) Initiation and promotion of bone differentiation by bone morphogenetic proteins. Journal of Bone and Mineral Research 8(Suppl. 2): S499-S502.
22. Roberts, W.E., Smith, R.K., Zilberman, Y., Mozsary, P.G. & Smith, R.S. (1984) Osseous adaptation to continuous loading of rigid endosseous implants. American Journal of Orthodontics 86: 95-111.
23. Rocchietta, I., Fontana, F., Addis, A., Schupbach, P. & Simion, M. (2009) Surface-modified zirconia implants: tissue response in rabbits. Clinical Oral Implants Research 20: 844-850.
24. Salata, L.A., Burgos, P.M., Rasmusson, L., Novaes, A.B., Papalexiou, V., Dahlin, C. & Sennerby, L. (2007) Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on bmp-2 and autogenous bone graft in the dog mandible. International Journal of Oral and Maxillofacial Surgery 36: 62-71.
25. Schliephake, H., Aref, A., Scharnweber, D., Bierbaum, S., Roessler, S. & Sewing, A. (2005) Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation. Clinical Oral Implants Research 16: 563-569.
26. Schliephake, H., Reiss, G., Urban, R., Neukam, F.W. & Guckel, S. (1993) Metal release from titanium fixtures during placement in the mandible: an experimental study. International Journal of Oral and Maxillofacial Implants 8: 502-511.
27. Sennerby, L., Dasmah, A., Larsson, B. & Iverhed, M. (2005) Bone tissue responses to surface-modified zirconia implants: a histomorphometric and removal torque study in the rabbit. Clinical Implant Dentistry and Related Research 7(Suppl. 1): S13-S20.
28. Shah, D.A. & Madden, L.V. (2004) Nonparametric analysis of ordinal data in designed factorial experiments. Phyto 92: 33-43.
29. Shin, D., Blanchard, S.B., Ito, M. & Chu, T.M. (2011) Peripheral quantitative computer tomographic, histomorphometric, and removal torque analyses of two different non-coated implants in a rabbit model. Clinical Oral Implants Research 22: 242-250.
30. Sykaras, N., Iacopino, A.M., Triplett, R.G. & Marker, V.A. (2004) Effect of recombinant human bone morphogenetic protein-2 on the osseointegration of dental implants: a biomechanics study. Clinical Oral Investigations 8: 196-205.
31. Sykaras, N., Triplett, R.G., Nunn, M.E., Iacopino, A.M. & Opperman, L.A. (2001) Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants. Clinical Oral Implants Research 12: 339-349.
32. Urban, R.M., Jacobs, J.J., Tomlinson, M.J., Gavrilovic, J., Black, J. & Peoc'h, M. (2000) Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. Journal of Bone and Joint Surgery 82: 457-476.
33. Urist, M.R. (1965) Bone: formation by autoinduction. Science 150: 893-899.
34. Valentine-Thon, E. & Schiwara, H.W. (2003) Validity of melisa for metal sensitivity testing. Neuro Endocrinology Letters 24: 57-64.
35. Wikesjo, U.M., Xiropaidis, A.V., Qahash, M., Lim, W.H., Sorensen, R.G., Rohrer, M.D., Wozney, J.M. & Hall, J. (2008) Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (type ii bone) in dogs. Journal of Clinical Periodontology 35: 985-991.