Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1352-1362

  Lloyd, Mitchell M ^a   Grima, Michael A ^a   Rayner, Benjamin S ^a,b   Hadfield, Katrina A ^a   Davies, Michael J ^a,b   Hawkins, Clare L ^a,b  

^a HEART RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Apoptosis; Endothelial cell; Free radicals; Hypochlorous acid; Hypothiocyanous acid; Myeloperoxidase

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 7; CYTOCHROME C; ENDONUCLEASE G; GLUTATHIONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOCHLOROUS ACID; HYPOTHIOCYANOUS ACID; MYELOPEROXIDASE; OXIDIZING AGENT; THIOL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLOOD VESSEL REACTIVITY; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM CELL; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

MAMMALIA;

5-IODOACETAMIDOFLUORESCEIN; 5-THIO-2-NITROBENZOIC ACID; AC-DEVD-MCA; ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPARTIC ACID Α-(2-METHYLCOUMARYL-7-AMIDE; AIF; APOPTOSIS; APOPTOSIS-INDUCING FACTOR; BENZOYL OXYCARBONYL-VAL-ALA-DL-ASP FLUOROMETHYL KETONE; ENDOG; ENDONUCLEASE G; ENDOTHELIAL CELL; ETBR; ETHIDIUM BROMIDE; FREE RADICALS; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GSH; HANKS' BUFFERED SALT SOLUTION; HBSS; HCAEC; HUMAN CORONARY ARTERY ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUVEC; HYPOCHLOROUS ACID; HYPOTHIOCYANOUS ACID; IAF; MPO; MYELOPEROXIDASE; REDUCED GLUTATHIONE; TNB; TNFR; TUMOR NECROSIS FACTOR RECEPTOR; Z-VAD-FMK;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; ATHEROSCLEROSIS; CASPASE 3; CASPASE 7; CASPASE INHIBITORS; CELL LINE; CELL SURVIVAL; CORONARY VESSELS; CYTOCHROMES C; ENDODEOXYRIBONUCLEASES; ENDOTHELIAL CELLS; GLUTATHIONE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MITOCHONDRIAL MEMBRANES; NECROSIS; OXIDATION-REDUCTION; PERMEABILITY; PEROXIDASE; SULFHYDRYL COMPOUNDS; THIOCYANATES;

EID: 84886744224     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.10.007     Document Type: Article

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