An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles

Journal of Surgical Research

Volumn 185, Issue 1, 2013, Pages 45-55

  Girgis, Mark D ^a,b   Federman, Noah ^c   Rochefort, Matthew M ^a,b   McCabe, Katelyn E ^c   Wu, Anna M ^c   Nagy, Jon O ^d   Denny, Christopher ^c   Tomlinson, James S ^a,b  

^a Greater Los Angeles ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NanoValent Pharmaceuticals Inc   (United States)

Author keywords

Antibody; CA19 9; Imaging; Nanoparticle; Pancreatic cancer

Indexed keywords

ANTIBODY; CA 19 9 CYSTEINE DIABODY I 124; CA 19-9 ANTIGEN; LIPOSOME; NANOPARTICLE; POLYMERIZED LIPOSOMAL NANOPARTICLE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ENGINEERING; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CARBOXY TERMINAL SEQUENCE; CONJUGATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; ISOTOPE LABELING; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PANCREAS CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; TUMOR XENOGRAFT;

ANTIBODY; CA19-9; IMAGING; NANOPARTICLE; PANCREATIC CANCER;

ANIMALS; ANTIBODIES, BISPECIFIC; CA-19-9 ANTIGEN; CELL LINE, TUMOR; CYSTINE; FEMALE; HUMANS; IMMUNOTHERAPY; LIPOSOMES; MICE; MICE, NUDE; MULTIPLE MYELOMA; NANOPARTICLES; PANCREATIC NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN ENGINEERING; SINGLE-CHAIN ANTIBODIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886725334     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.05.095     Document Type: Article

References (33)

1. American Cancer Society Cancer facts & figures 2011 American Cancer Society Atlanta (GA)
2. N. Wasif, C.Y. Ko, and J. Farrell Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging? Ann Surg Oncol 17 2010 2312
3. V. Kenanova, and A.M. Wu Tailoring antibodies for radionuclide delivery Expert Opin Drug Deliv 3 2006 53
4. A.A. Kortt, O. Dolezal, B.E. Power, and P.J. Hudson Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting Biomol Eng 18 2001 95
5. P. Holliger, T. Prospero, and G. Winter "Diabodies": small bivalent and bispecific antibody fragments Proc Natl Acad Sci U S A 90 1993 6444
6. G.P. Adams, M.S. Tai, and J.E. McCartney Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers Clin Cancer Res 12 2006 1599
7. T. Olafsen, C.W. Cheung, and P.J. Yazaki Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications Protein Eng Des Sel 17 2004 21
8. J.A. Carmichael, B.E. Power, and T.P. Garrett The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility J Mol Biol 326 2003 341
9. B.D. Weinberg, H. Ai, E. Blanco, J.M. Anderson, and J. Gao Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods J Biomed Mater Res A 81 2007 161
10. L. Brannon-Peppas, and J.O. Blanchette Nanoparticle and targeted systems for cancer therapy Adv Drug Deliv Rev 56 2004 1649
11. N. Federman, and C.T. Denny Targeting liposomes toward novel pediatric anticancer therapeutics Pediatr Res 67 2010 514
12. M.D. Girgis, V. Kenanova, T. Olafsen, K.E. McCabe, A.M. Wu, and J.S. Tomlinson Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer J Surg Res 170 2011 169
13. S.J. Sirk, T. Olafsen, B. Barat, K.B. Bauer, and A.M. Wu Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2 Bioconjug Chem 19 2008 2527
14. C.R. Bebbington, G. Renner, and S. Thomson High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker Biotechnology (N Y) 10 1992 169
15. G. Galfre, and C. Milstein Preparation of monoclonal antibodies: strategies and procedures Methods Enzymol 73 1981 3
16. V. Kenanova, T. Olafsen, and D.M. Crow Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments Cancer Res 65 2005 622
17. R.E. Bruehl, F. Dasgupta, and T.R. Katsumoto Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands Biochemistry 40 2001 5964
18. H. Koprowski, Z. Steplewski, and K. Mitchell Colorectal carcinoma antigens detected by hybridoma antibodies Somatic Cell Genet 5 1979 957
19. M.A. Markwell, and C.F. Fox Surface-specific iodination of membrane proteins of viruses and eucaryotic cells using 1,3,4,6-tetrachloro-3alpha, 6alpha-diphenylglycoluril Biochemistry 17 1978 4807
20. J.E. McCartney, M.S. Tai, and R.M. Hudziak Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26-10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides Protein Eng 8 1995 301
21. L.E. Williams, A.M. Wu, and P.J. Yazaki Numerical selection of optimal tumor imaging agents with application to engineered antibodies Cancer Biother Radiopharm 16 2001 25
22. M. Defrise, P.E. Kinahan, and D.W. Townsend Exact and approximate rebinning algorithms for 3-D PET data IEEE Trans Med Imaging 16 1997 145
23. A.M. Loening, and S.S. Gambhir AMIDE: a free software tool for multimodality medical image analysis Mol Imaging 2 2003 131
24. D.W. Tonge, J.F. Hennam, A.R. Greene, I.D. Lee, and M.D. Edge Cloning and characterization of 1116NS19.9 heavy and light chain cDNAs and expression of antibody fragments in Escherichia coli Year Immunol 7 1993 56
25. D. Day, and H. Ringsdorf Polymerization of diacetylene carbonic-acid monolayers at gas-water interface J Polym Sci Pol Lett 16 1978 205
26. H. Eckhardt, D.S. Boudreaux, and R.R. Chance Effects of substituent-induced strain on the electronic-structure of polydiacetylenes J Chem Phys 85 1986 4116
27. J. Olmsted, and M. Strand Fluorescence of polymerized diacetylene bilayer films J Phys Chem-US 87 1983 4790
28. C. Haglund, J. Lindgren, P.J. Roberts, and S. Nordling Gastrointestinal cancer-associated antigen CA 19-9 in histological specimens of pancreatic tumours and pancreatitis Br J Cancer 53 1986 189
29. T.S. Loy, S.C. Sharp, C.J. Andershock, and S.B. Craig Distribution of CA 19-9 in adenocarcinomas and transitional cell carcinomas. An immunohistochemical study of 527 cases Am J Clin Pathol 99 1993 726
30. J. Makovitzky The distribution and localization of the monoclonal antibody-defined antigen 19-9 (CA19-9) in chronic pancreatitis and pancreatic carcinoma. An immunohistochemical study Virchows Arch B Cell Pathol Incl Mol Pathol 51 1986 535
31. G. Ohshio, K. Ogawa, and H. Kudo Immunohistochemical studies on the localization of cancer associated antigens DU-PAN-2 and CA19-9 in carcinomas of the digestive tract J Gastroenterol Hepatol 5 1990 25
32. S. Ahlgren, H. Wallberg, and T.A. Tran Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2:2395, with C-terminally engineered cysteine J Nucl Med 50 2009 781
33. M.S. Co, N.F. Landolfi, and J.O. Nagy Properties and pharmacokinetics of two humanized antibodies specific for L-selectin Immunotechnology 4 1999 253