Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates

Pathogens and Disease

Volumn 68, Issue 1, 2013, Pages 8-11

  García Contreras, Rodolfo ^a   Martínez Vázquez, Mariano ^b   Velázquez Guadarrama, Norma ^c   Villegas Pañeda, Alejandra Guadalupe ^b   Hashimoto, Takahiro ^d   Maeda, Toshinari ^d   Quezada, Héctor ^e,f   Wood, Thomas K ^g  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^d KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Alkaline protease; Antivirulence resistance; Elastase; Pyocyanin; Quorum quenching

Indexed keywords

ALKALINE PROTEINASE; AMINOGLYCOSIDE; BETA LACTAM; ELASTASE; FLUOROURACIL; FURANONE DERIVATIVE; PYOCYANINE; QUINOLONE DERIVATIVE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; FURAN DERIVATIVE; FURANONE C 30; FURANONE C-30; PANCREATIC ELASTASE; PROTEINASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BROMINATION; CONTROLLED STUDY; ENZYME SYNTHESIS; MICROBIAL ATTENUATION; NONHUMAN; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; CHILD; DRUG EFFECT; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PSEUDOMONAS INFECTION; DRUG EFFECTS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHILD; DRUG RESISTANCE, BACTERIAL; ENDOPEPTIDASES; FLUOROURACIL; FURANS; HUMANS; PANCREATIC ELASTASE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PYOCYANINE; QUORUM SENSING;

EID: 84886686961     PISSN: None     EISSN: 2049632X     Source Type: Journal    
DOI: 10.1111/2049-632X.12039     Document Type: Article

References (15)

1. Bjarnsholt T, Tolker-Nielsen T, Hoiby N & Givskov M (2010) Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. Expert Rev Mol Med 12: e11.
2. Defoirdt T, Miyamoto CM, Wood TK, Meighen EA, Sorgeloos P, Verstraete W & Bossier P (2007) The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR. Environ Microbiol 9: 2486-2495.
3. Hentzer M, Riedel K, Rasmussen TB et al. (2002) Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148: 87-102.
4. Hentzer M, Wu H, Andersen JB et al. (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 22: 3803-3815.
5. Howe TR & Iglewski BH (1984) Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model. Infect Immun 43: 1058-1063.
6. Jarvis WR & Martone WJ (1992) Predominant pathogens in hospital infections. J Antimicrob Chemother 29(Suppl A): 19-24.
7. Maeda T, García-Contreras R, Pu M, Sheng L, Garcia LR, Tomas M & Wood TK (2012) Quorum quenching quandary: resistance to antivirulence compounds. ISME J 6: 493-501.
8. Manefield M, Rasmussen TB, Henzter M, Andersen JB, Steinberg P, Kjelleberg S & Givskov M (2002) Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 148: 1119-1127.
9. Manny AJ, Kjelleberg S, Kumar N, de Nys R, Read RW & Steinberg P (1997) Reinvestigation of the sulfuric acid-catalysed cyclisation of brominated 2-alkyllevulinic acids to 3-alkyl-5-methylene-2(5H)-furanones. Tetrahedron 53: 15813-15826.
10. Poole K (2011) Pseudomonas aeruginosa: resistance to the max. Front Microbiol 2: 65.
11. Rasko DA & Sperandio V (2010) Anti-virulence strategies to combat bacteria-mediated disease. Nat Rev Drug Discov 9: 117-128.
12. Schaber JA, Carty NL, McDonald NA, Graham ED, Cheluvappa R, Griswold JA & Hamood AN (2004) Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. J Med Microbiol 53: 841-853.
13. Ueda A, Attila C, Whiteley M & Wood TK (2009) Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist. Microb Biotechnol 2: 62-74.
14. Winzer K & Williams P (2001) Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria. Int J Med Microbiol 291: 131-143.
15. Wu H, Song Z, Hentzer M, Andersen JB, Molin S, Givskov M & Hoiby N (2004) Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J Antimicrob Chemother 53: 1054-1061.