Prescribing nonopioids in mechanically ventilated critically ill patients

Journal of Critical Care

Volumn 28, Issue 4, 2013, Pages 534.e7-534.e12

  Payen, Jean Francois ^a   Genty, Celine ^b   Mimoz, Olivier ^c   Mantz, Jean ^d   Bosson, Jean Luc ^b   Chanques, Gerald ^e  

^a HÔPITAL MICHALLON   (France)

^b LABORATOIRE TIMC IMAG   (France)

^c POITIERS UNIVERSITY HOSPITAL   (France)

^d BEAUJON HOSPITAL   (France)

^e HÔPITAL SAINT ELOI   (France)

Author keywords

Analgesia; Intensive care unit; Opioids; Paracetamol; Sedation

Indexed keywords

FENTANYL; HYPNOTIC AGENT; KETOPROFEN; MIDAZOLAM; MORPHINE; NEFOPAM; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; PROPOFOL; REMIFENTANIL; SUFENTANIL; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT;

ADULT; AGED; ANALGESIA; ARTICLE; ARTIFICIAL VENTILATION; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DELIRIUM; DISEASE SEVERITY; FEMALE; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; PAIN ASSESSMENT; POST HOC ANALYSIS; POSTOPERATIVE PAIN; PRESCRIPTION; SCORING SYSTEM; SELF REPORT; SINGLE DRUG DOSE; WITHDRAWAL SYNDROME; CHI SQUARE DISTRIBUTION; CLINICAL PRACTICE; CRITICAL ILLNESS; DRUG COMBINATION; MIDDLE AGED; NONPARAMETRIC TEST; OPIOIDS; SEDATION; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; STATISTICS;

ANALGESIA; INTENSIVE CARE UNIT; OPIOIDS; PARACETAMOL; SEDATION;

ACETAMINOPHEN; ADULT; AGED; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; NEFOPAM; PAIN MANAGEMENT; PAIN MEASUREMENT; PHYSICIAN'S PRACTICE PATTERNS; RESPIRATION, ARTIFICIAL; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 84886674212     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2012.10.006     Document Type: Article

References (27)

1. Sessler C.N., Varney K. Patient-focused sedation and analgesia in the ICU. Chest 2008, 133:552-565.
2. Reschreiter H., Maiden M., Kapila A. Sedation practice in the intensive care unit: a UK national survey. Crit Care 2008, 12:R152.
3. Martin J., Franck M., Sigel S., et al. Changes in sedation management in German intensive care units between 2002 and 2006: a national follow up survey. Crit Care 2007, 11:R124.
4. Gommers D., Bakker J. Medications for analgesia and sedation in the intensive care unit: an overview. Crit Care 2008, 12(Suppl. 3):S4.
5. Payen J.F., Chanques G., Mantz J., et al. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 2007, 106:687-695.
6. Kehlet H., Dahl J.B. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg 1993, 77:1048-1056.
7. Benhamou D., Berti M., Brodner G., et al. Postoperative Analgesic THerapy Observational Survey (PATHOS): a practice pattern study in 7 central/southern European countries. Pain 2008, 136:134-141.
8. Marret E., Kurdi O., Zufferey P., et al. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005, 102:1249-1260.
9. Ong C.K., Seymour R.A., Lirk P., et al. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg 2010, 110:1170-1179.
10. Payen J.F., Bosson J.L., Chanques G., et al. Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit: a post hoc analysis of the DOLOREA study. Anesthesiology 2009, 111:1308-1316.
11. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
12. Payen J.F., Bru O., Bosson J.L., et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 2001, 29:2258-2263.
13. Harris C.E., O'Donnell C., Macmillan R.R., et al. Use of propofol by infusion for sedation of patients undergoing haemofiltration: assessment of the effect of haemofiltration on the level of sedation and on blood propofol concentration. J Drug Dev 1991, 4(Suppl. 3):37-39.
14. Guillou N., Tanguy M., Seguin P., et al. The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery. Anesth Analg 2003, 97:843-847.
15. Pandey C.K., Bose N., Garg G., et al. Gabapentin for the treatment of pain in Guillain-Barre syndrome: a double-blinded, placebo-controlled, crossover study. Anesth Analg 2002, 95:1719-1723.
16. 2 for off pump coronary artery bypass surgery. Ann Card Anaesth 2010, 13:28-33.
17. Fletcher D., Fermanian C., Mardaye A., et al. A patient-based national survey on postoperative pain management in France reveals significant achievements and persistent challenges. Pain 2008, 137:441-451.
18. McNicol E.D., Tzortzopoulou A., Cepeda M.S., et al. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis. Br J Anaesth 2011, 106:764-775.
19. Mackenzie I., Forrest K., Thompson F., et al. Effects of acetaminophen administration to patients in intensive care. Intensive Care Med 2000, 26:1408.
20. Evans M.S., Lysakowski C., Tramer M.R. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth 2008, 101:610-617.
21. Chanques G., Sebbane M., Constantin J.M., et al. Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. Br J Anaesth 2011, 106:336-343.
22. Li D., Puntillo K., Miaskowski C. A review of objective pain measures for use with critical care adult patients unable to self-report. J Pain 2008, 9:2-10.
23. Pasero C., Puntillo K., Li D., et al. Structured approaches to pain management in the ICU. Chest 2009, 135:1665-1672.
24. Bonhomme V., Uutela K., Hans G., et al. Comparison of the surgical Pleth Index with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia. Br J Anaesth 2011, 106:101-111.
25. Bourgeois E., Sabourdin N., Louvet N., et al. Minimal alveolar concentration of sevoflurane inhibiting the reflex pupillary dilatation after noxious stimulation in children and young adults. Br J Anaesth 2012, 108:648-654.
26. Chanques G., Viel E., Constantin J.M., et al. The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain 2010, 151:711-721.
27. Strom T., Martinussen T., Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010, 375:475-480.