Human β defensin-3 induces chemokines from monocytes and macrophages: Diminished activity in cells from HIV-infected persons

Immunology

Volumn 140, Issue 4, 2013, Pages 413-420

  Petrov, Velizar ^a   Funderburg, Nicholas ^b   Weinberg, Aaron ^a   Sieg, Scott ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemokine; Defensin; HIV; Macrophage; Monocyte

Indexed keywords

ANGIOGENIC FACTOR; B7 ANTIGEN; BETA DEFENSIN 3; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CD14 ANTIGEN; CD16 ANTIGEN; CD86 ANTIGEN; CENTRAL STIMULANT AGENT; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR2; CXCL1 CHEMOKINE; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; VASCULOTROPIN;

ADULT; ARTICLE; CELL ACTIVITY; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULATION; T LYMPHOCYTE ACTIVATION;

CHEMOKINE; DEFENSIN; HIV; MACROPHAGE; MONOCYTE;

ANTIGENS, CD80; ANTIGENS, CD86; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CASE-CONTROL STUDIES; CELLS, CULTURED; CHEMOKINES; CHEMOTAXIS; HIV INFECTIONS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPEPTIDES; MACROPHAGES; MONOCYTES; RECEPTORS, CHEMOKINE; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84886611791     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12148     Document Type: Article

References (28)

1. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001; 276:5707-13.
2. Jin G, Kawsar HI, Hirsch SA et al. An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis. PLoS ONE 2010; 5:e10993.
3. Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, Harding CV, Weinberg A, Sieg SF. Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci USA 2007; 104:18631-5.
4. Funderburg N, Luciano AA, Jiang W, Rodriguez B, Sieg SF, Lederman MM. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS ONE 2008; 3:e1915.
5. Kawsar HI, Weinberg A, Hirsch SA, Venizelos A, Howell S, Jiang B, Jin G. Overexpression of human β-defensin-3 in oral dysplasia: potential role in macrophage trafficking. Oral Oncol 2009; 45:696-702.
6. Wu Z, Hoover DM, Yang D, Boulegue C, Santamaria F, Oppenheim JJ, Lubkowski J, Lu W. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3. Proc Natl Acad Sci U S A 2003; 100:8880-5.
7. + population of monocytes in inflammatory bowel disease mucosa - implications for pathogenesis. Clin Exp Immunol 1995; 100:291-7.
8. Funderburg NT, Jadlowsky JK, Lederman MM, Feng Z, Weinberg A, Sieg SF. The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes. Immunology 2011; 134:151-60.
9. Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1β processing and release. J Immunol 2004; 172:4987-94.
10. van der Does AM, Beekhuizen H, Ravensbergen B et al. LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature. J Immunol 2010; 185:1442-9.
11. Funderburg NT, Sieg SF. Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients. J Leukoc Biol 2012; 92:1103-9.
12. Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 1997; 185:1595-604.
13. Rodenburg RJ, Brinkhuis RF, Peek R, Westphal JR, Van Den Hoogen FH, van Venrooij WJ, van de Putte LB. Expression of macrophage-derived chemokine (MDC) mRNA in macrophages is enhanced by interleukin-1β, tumor necrosis factor α, and lipopolysaccharide. J Leukoc Biol 1998; 63:606-11.
14. Lioi AB, Reyes Rodriguez AL, Funderburg NT, Feng Z, Weinberg A, Sieg SF. Membrane damage and repair in primary monocytes exposed to human β-defensin-3. J Leukoc Biol 2012; 92:1083-91.
15. dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; 33:375-86.
16. Vasu C, Wang A, Gorla SR, Kaithamana S, Prabhakar BS, Holterman MJ. CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol 2003; 15:167-75.
17. + -adaptive regulatory T cell generation. J Immunol 2008; 180:6566-76.
18. Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 1994; 91:2752-6.
19. Combadiere C, Ahuja SK, Tiffany HL, Murphy PM. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES. J Leukoc Biol 1996; 60:147-52.
20. Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J Biol Chem 1996; 271:17161-6.
21. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J Biol Chem 1998; 273:1764-8.
22. Geiser T, Dewald B, Ehrengruber MU, Clark-Lewis I, Baggiolini M. The interleukin-8-related chemotactic cytokines GROα, GROβ, and GROγ activate human neutrophil and basophil leukocytes. J Biol Chem 1993; 268:15419-24.
23. Papadopoulou C, Corrigall V, Taylor PR, Poston RN. The role of the chemokines MCP-1, GRO-α, IL-8 and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques. Cytokine 2008; 43:181-6.
24. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246:1306-9.
25. Ancuta P, Kamat A, Kunstman KJ et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS ONE 2008; 3:e2516.
26. Jiang W, Lederman MM, Salkowitz JR, Rodriguez B, Harding CV, Sieg SF. Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in α/β interferon responsiveness and production. J Virol 2005; 79:4109-19.
27. Hardy GA, Sieg SF, Rodriguez B, Jiang W, Asaad R, Lederman MM, Harding CV. Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression. Blood 2009; 113:5497-505.
28. Tilton JC, Johnson AJ, Luskin MR et al. Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons. J Virol 2006; 80:11486-97.