Severe toxicity and polymerase-γ gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy

Pharmacogenetics and Genomics

Volumn 23, Issue 11, 2013, Pages 624-626

  Van Oosterhout, Joep J ^a,c   Gardner, Kristian ^d   Mallewa, Jane ^a,b   Kaunda, Symon ^a   Kampira, Elizabeth ^b,e   Payne, Brendan ^d   Heyderman, Robert S ^a   Chinnery, Patrick ^d  

^a UNIVERSITY OF MALAWI   (Malawi)

^b Gut and Metabolism Laboratory   (United Kingdom)

^c DIGNITAS INTERNATIONAL   (Malawi)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antiretroviral therapy; Malawi; Mitochondrial toxicity; Mutations; POLG; Stavudine

Indexed keywords

STAVUDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; DIABETES MELLITUS; FEMALE; GENE; GENE MUTATION; HUMAN; HYPERLACTATEMIA; LACTIC ACIDOSIS; LIPODYSTROPHY; MALAWI; MALE; MITOCHONDRIAL TOXICITY; PERIPHERAL NEUROPATHY; POLYMERASE GAMMA GENE; PRIORITY JOURNAL; SIDE EFFECT; SYMPTOMATIC HYPERLACTATEMIA;

ACIDOSIS, LACTIC; ADULT; ANTI-HIV AGENTS; COHORT STUDIES; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENETIC VARIATION; HIV INFECTIONS; HUMANS; MALAWI; MALE; MIDDLE AGED; PERIPHERAL NERVOUS SYSTEM DISEASES; POLYMORPHISM, SINGLE NUCLEOTIDE; STAVUDINE;

EID: 84886594096     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283655053     Document Type: Article

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