PPARγ forms a bridge between DNA methylation and histone acetylation at the C/EBPα gene promoter to regulate the balance between osteogenesis and adipogenesis of bone marrow stromal cells

FEBS Journal

Volumn 280, Issue 22, 2013, Pages 5801-5814

  Zhao, Qing Hua ^a   Wang, Shou Guo ^b   Liu, Shao Xian ^c   Li, Ji Peng ^a   Zhang, Yong Xing ^a   Sun, Zhong Yi ^a   Fan, Qi Ming ^d   Tian, Ji Wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b THE AFFILIATED HUAIAN NO 1 PEOPLE S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c YANTAISHAN HOSPITAL   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

adipogenesis; C EBP ; epigenetics; osteogenesis; PPAR

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; DEXAMETHASONE; HISTONE DEACETYLASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; C EBPALPHA GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EXPERIMENTAL MOUSE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; HEMATOPOIETIC STEM CELL; HISTONE ACETYLATION; MOUSE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ADIPOGENESIS; C/EBPΑ; EPIGENETICS; OSTEOGENESIS; PPARΓ;

ACETYLATION; ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL LINE; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE 1; HISTONES; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; OSTEOGENESIS; OSTEOPOROSIS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

MUS;

EID: 84886588706     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12500     Document Type: Article

References (14)

1. Nuttall ME, &, Gimble JM, (2000) Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone 27, 177-184.
2. Fan Q, Tang T, Zhang X, &, Dai K, (2009) The role of CCAAT/enhancer binding protein (C/EBP)-α in osteogenesis of C3H10T1/2 cells induced by BMP-2. J Cell Mol Med 13, 2489-2505.
3. Zuo Y, Qiang L, &, Farmer SR, (2006) Activation of CCAAT/enhancer-binding protein (C/EBP) α expression by C/EBPβ during adipogenesis requires a peroxisome proliferator-activated receptor-γ- associated repression of HDAC1 at the C/e bpα gene promoter. J Biol Chem 281, 7960-7967.
4. Visser ME, Kropman E, Kranendonk ME, Koppen A, Hamers N, Stroes ES, Kalkhoven E, &, Monajemi H, (2011) Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARgamma mutation (Y151C). Diabetologia 54, 1639-1644.
5. Baksh D, Song L, &, Tuan RS, (2004) Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8, 301-316.
6. Fux C, Mitta B, Kramer BP, &, Fussenegger M, (2004) Dual-regulated expression of C/EBP-α and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts. Nucleic Acids Res 32, e1.
7. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, &, Spiegelman BM, (1999) Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 3, 151-158.
8. Kim JB, Wright HM, Wright M, &, Spiegelman BM, (1998) ADD1/SREBP1 activates PPARγ through the production of endogenous ligand. Proc Natl Acad Sci USA 95, 4333-4337.
9. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, &, Spiegelman BM, (2002) C/EBPα induces adipogenesis through PPARγ: a unified pathway. Genes Dev 16, 22-26.
10. Razin A, (1998) CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17, 4905-4908.
11. Razin A, &, Cedar H, (1977) Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci USA 74, 2725-2728.
12. Reed BC, &, Lane MD, (1980) Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 77, 285-289.
13. Student AK, Hsu RY, &, Lane MD, (1980) Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem 255, 4745-4750.
14. Lim S, Jang HJ, Kim JK, Kim JM, Park EH, Yang JH, Kim YH, Yea K, Ryu SH, &, Suh PG, (2011) Ochratoxin A inhibits adipogenesis through the extracellular signal-related kinases-peroxisome proliferator-activated receptor-γ pathway in human adipose tissue-derived mesenchymal stem cells. Stem Cells Dev 20, 415-426.