Serine/threonine phosphatases regulate platelet αiIbβ 3 integrin receptor outside-in signaling mechanisms and clot retraction

Life Sciences

Volumn 93, Issue 20, 2013, Pages 707-713

  Moscardó, Antonio ^a   Santos, María Teresa ^a   Latorre, Ana ^a   Madrid, Isabel ^b   Vallés, Juana ^a  

^a INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

FAK; Integrin IIb 3; Outside in signaling; Platelet; PP2A

Indexed keywords

FOCAL ADHESION KINASE; INTEGRIN RECEPTOR; OKADAIC ACID; PLATELET ALPHA 2B BETA 3 INTEGRIN RECEPTOR; PROTEIN KINASE SYK; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SERINE THREONINE PHOSPHATASE; THROMBIN; TRITON X 100; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE;

ANTIBODY SPECIFICITY; ARTICLE; BLOOD CLOT RETRACTION; CYTOLYSIS; CYTOSKELETON; INTRACELLULAR SIGNALING; PROTEIN PHOSPHORYLATION; PROTEIN TYROSINE KINAS; THROMBOCYTE AGGREGATION; WHOLE CELL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

BLOOD PLATELETS; CLOT RETRACTION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASES; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SIGNAL TRANSDUCTION;

EID: 84886583695     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.09.020     Document Type: Article

References (36)

1. N. Alrehani, S. Pradhan, T. Khatlani, L. Kailasam, and K.V. Vijayan Distinct roles for the alpha, beta and gamma1 isoforms of protein phosphatase 1 in the outside-in alphaIIbbeta3 integrin signalling-dependent functions Thromb Haemost 109 2013 118 126
2. V. Artcanuthurry, F. Grelac, J. Maclouf, E. Martin-Cramer, and S. Levy-Toledano Serine/threonine dephosphorylation may be involved in tyrosine phosphorylation: a new mode of signal transduction in platelets Semin Thromb Hemost 22 1996 317 326
3. L. Asmis, F.C. Tanner, I. Sudano, T.F. Luscher, and G.G. Camici DMSO inhibits human platelet activation through cyclooxygenase-1 inhibition. A novel agent for drug eluting stents? Biochem Biophys Res Commun 391 2010 1629 1633
4. P. Cohen, C.F. Holmes, and Y. Tsukitani Okadaic acid: a new probe for the study of cellular regulation Trends Biochem Sci 15 1990 98 102
5. B.S. Coller, and S.J. Shattil The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend Blood 112 2008 3011 3025
6. A.B. Dounay, and C.J. Forsyth Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor Curr Med Chem 9 2002 1939 1980
7. J.J. Fernandez, M.L. Candenas, M.L. Souto, M.M. Trujillo, and M. Norte Okadaic acid, useful tool for studying cellular processes Curr Med Chem 9 2002 229 262
8. M.C. Frame, H. Patel, B. Serrels, D. Lietha, and M.J. Eck The FERM domain: organizing the structure and function of FAK Nat Rev Mol Cell Biol 11 2010 802 814
9. F.C. Gushiken, V. Patel, Y. Liu, S. Pradhan, A.L. Bergeron, and Y. Peng Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling J Biol Chem 283 2008 12862 12869
10. H. Ishihara, B.L. Martin, D.L. Brautigan, H. Karaki, H. Ozaki, and Y. Kato Calyculin A and okadaic acid: inhibitors of protein phosphatase activity Biochem Biophys Res Commun 159 1989 871 877
11. V. Janssens, and J. Goris Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling Biochem J 353 2001 417 439
12. P. Ji, and B. Haimovich Integrin alpha IIb beta 3-mediated pp125FAK phosphorylation and platelet spreading on fibrinogen are regulated by PI 3-kinase Biochim Biophys Acta 1448 1999 543 552
13. P. Kalev, and A.A. Sablina Protein phosphatase 2A as a potential target for anticancer therapy Anticancer Agents Med Chem 11 2011 38 46
14. K.M. Lerea Thrombin-induced effects are selectively inhibited following treatment of intact human platelets with okadaic acid Biochemistry 30 1991 6819 6824
15. K.M. Lerea Inhibitors of protein phosphatase type 1 and 2A attenuate phosphatidylinositol metabolism and Ca(2 +)-transients in human platelets. Role of a cdc2-related protein kinase Biochemistry 31 1992 6553 6561
16. S. Levy-Toledano Platelet signal transduction pathways: could we organize them into a 'hierarchy'? Haemostasis 29 1999 4 15
17. S. Levy-Toledano, C. Gallet, F. Nadal, M. Bryckaert, J. Maclouf, and J.P. Rosa Phosphorylation and dephosphorylation mechanisms in platelet function: a tightly regulated balance Thromb Haemost 78 1997 226 233
18. A. Moscardo, J. Valles, M. Pinon, J. Aznar, V. Martinez-Sales, and M.T. Santos Regulation of cytosolic PlA2 activity by PP1/PP2A serine/threonine phosphatases in human platelets Platelets 17 2006 405 415
19. D.K. Newman The Y's that bind: negative regulators of Src family kinase activity in platelets J Thromb Haemost 7 Suppl. 1 2009 195 199
20. A. Obergfell, K. Eto, A. Mocsai, C. Buensuceso, S.L. Moores, and J.S. Brugge Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton J Cell Biol 157 2002 265 275
21. S. Osdoit, and J.P. Rosa Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation J Biol Chem 276 2001 6703 6710
22. L.V. Parise Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation Curr Opin Cell Biol 11 1999 597 601
23. T. Pawson, and J.D. Scott Signaling through scaffold, anchoring, and adaptor proteins Science 278 1997 2075 2080
24. D.R. Phillips, L. Nannizzi-Alaimo, and K.S. Prasad Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling Thromb Haemost 86 2001 246 258
25. S. Pradhan, N. Alrehani, V. Patel, T. Khatlani, and K.V. Vijayan Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin alphaIIbbeta3 to fibrinogen J Biol Chem 285 2010 29059 29068
26. M.T. Santos, J. Valles, A.J. Marcus, L.B. Safier, M.J. Broekman, and N. Islam Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. A new approach to platelet activation and recruitment J Clin Invest 87 1991 571 580
27. M.T. Santos, A. Moscardo, J. Valles, M. Martinez, M. Pinon, and J. Aznar Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets Circulation 102 2000 1924 1930
28. M.D. Schaller Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions J Cell Sci 123 2010 1007 1013
29. S.M. Schoenwaelder, S.P. Jackson, Y. Yuan, M.S. Teasdale, H.H. Salem, and C.A. Mitchell Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers J Biol Chem 269 1994 32479 32487
30. S.J. Shattil Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways Thromb Haemost 82 1999 318 325
31. S.J. Shattil Integrins and Src: dynamic duo of adhesion signaling Trends Cell Biol 15 2005 399 403
32. S.J. Shattil The beta3 integrin cytoplasmic tail: protein scaffold and control freak J Thromb Haemost 7 Suppl. 1 2009 210 213
33. S.J. Shattil, M. Cunningham, and J.A. Hoxie Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry Blood 70 1987 307 315
34. S.J. Shattil, H. Kashiwagi, and N. Pampori Integrin signaling: the platelet paradigm Blood 91 1998 2645 2657
35. J. Valles, M.T. Santos, A.J. Marcus, L.B. Safier, M.J. Broekman, and N. Islam Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins J Clin Invest 92 1993 1357 1365
36. H. Wang, B. Yan, L.L. Satterwhite, Q. Ma, and P.J. Goldschmidt-Clermont Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3 Biochem Biophys Res Commun 367 2008 72 77