Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response

Journal of Pharmacological and Toxicological Methods

Volumn 69, Issue 1, 2014, Pages 1-8

  Deeti, Sudhakar ^a   O'Farrell, Sean ^a   Kennedy, Breandán N ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Drug treatment; Ocular toxicity; Visual behaviour assays; Visual function; Visualmotor response; Zebrafish

Indexed keywords

AMPICILLIN; ATROPINE; CHLORAMPHENICOL; CIMETIDINE; CISPLATIN; CLONIDINE; DIGOXIN; GENTAMICIN; HISTAMINE; IBUPROFEN; KANAMYCIN; MINOXIDIL; PENICILLIN G; QUININE; STREPTOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; EYE TOXICITY; ILLUMINATION; LARVA; LOCOMOTION; NONHUMAN; OPTOKINETIC STIMULATION; PREDICTION; PREDICTIVE VALUE; QUANTITATIVE ANALYSIS; SACCADIC EYE MOVEMENT; SENSITIVITY AND SPECIFICITY; TACTILE STIMULATION; TOUCH; VISUOMOTOR COORDINATION; WILD TYPE; ZEBRA FISH;

DAYS POST FERTILISATION; DPF; DRUG TREATMENT; ELECTRORETINOGRAM; ERG; HOURS POST FERTILISATION; HPF; OCULAR TOXICITY; OKR; OMR; OPTOKINETIC RESPONSE; OPTOMOTOR RESPONSE; VISUAL BEHAVIOUR ASSAYS; VISUAL FUNCTION; VISUALMOTOR RESPONSE; VMR; ZEBRAFISH;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; LARVA; MOTOR ACTIVITY; NYSTAGMUS, OPTOKINETIC; RETINA; VISION, OCULAR; ZEBRAFISH;

EID: 84886473168     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.09.002     Document Type: Article

References (38)

1. Al-Tweigeri T., Magliocco A.M., DeCoteau J.F. Cortical blindness as a manifestation of hypomagnesemia secondary to cisplatin therapy: case report and review of literature. Gynecologic Oncology 1999, 72:120-122.
2. Barros T.P., Alderton W.K., Reynolds H.M., Roach A.G., Berghmans S. Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. British Journal of Pharmacology 2008, 154:1400-1413.
3. Brockerhoff S.E. Measuring the optokinetic response of zebrafish larvae. Nature Protocols 2006, 1:2448-2451.
4. Brockerhoff S.E., Hurley J.B., Janssen-Bienhold U., Neuhauss S.C., Driever W., Dowling J.E. A behavioral screen for isolating zebrafish mutants with visual system defects. Proceedings of the National Academy of Sciences of the United States of America 1995, 92:10545-10549.
5. Car B. Enabling technologies in reducing drug attrition due to safety failures. International Drug Discovery 2006, 1:53-56.
6. Caraceni A., Martini C., Spatti G., Thomas A., Onofrj M. Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. Acta Neurologica Scandinavica 1997, 96:260-261.
7. Cuatrecasas P. Drug discovery in jeopardy. Journal of Clinical Investigation 2006, 116:2837-2842.
8. D'Amico D.J., Caspers-Velu L., Libert J., Shanks E., Schrooyen M., Hanninen L.A., et al. Comparative toxicity of intravitreal aminoglycoside antibiotics. American Journal of Ophthalmology 1985, 100:264-275.
9. de Seze J. Atypical forms of optic neuritis. Revue Neurologique (Paris) 2012, 168:697-701.
10. Dyson E.H., Proudfoot A.T., Prescott L.F., Heyworth R. Death and blindness due to overdose of quinine. British Medical Journal (Clinical Research Ed.) 1985, 291:31-33.
11. Easter S.S., Nicola G.N. The development of vision in the zebrafish (Danio rerio). Developmental Biology 1996, 180:646-663.
12. Edelhauser H.F., Rowe-Rendleman C.L., Robinson M.R., Dawson D.G., Chader G.J., Grossniklaus H.E., et al. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Investigative Ophthalmology & Visual Science 2010, 51:5403-5420.
13. Emran F., Rihel J., Dowling J.E. A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. Journal of Visualized Experiments 2008, (20). (Oct 3). pii: 923. http://dx.doi.org/10.3791/923.
14. Fadool J.M., Dowling J.E. Zebrafish: a model system for the study of eye genetics. Progress in Retinal and Eye Research 2008, 27:89-110.
15. Fleisch V.C., Neuhauss S.C. Visual behavior in zebrafish. Zebrafish 2006, 3:191-201.
16. Fraunfelder F.W., Fraunfelder F.T. Adverse ocular drug reactions recently identified by the National Registry of Drug-Induced Ocular Side Effects. Ophthalmology 2004, 111:1275-1279.
17. Gamulescu M.A., Schalke B., Schuierer G., Gabel V.P. Optic neuritis with visual field defect-possible Ibuprofen-related toxicity. Annals of Pharmacotherapy 2006, 40:571-573.
18. Goldsmith P., Harris W.A. The zebrafish as a tool for understanding the biology of visual disorders. Seminars in Cell & Developmental Biology 2003, 14:11-18.
19. Gombos G.M. Bilateral optic neuritis following minoxidil administration. Annals of Ophthalmology 1983, 15:259-261.
20. Haefliger I.O., Meyer P., Flammer J., Luscher T.F. The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology?. Survey of Ophthalmology 1994, 39:123-132.
21. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic development of the zebrafish. Developmental Dynamics 1995, 203:253-310.
22. Kola I., Landis J. Can the pharmaceutical industry reduce attrition rates?. Nature Reviews. Drug Discovery 2004, 3:711-715.
23. Kwan A.S., Sahu A., Palexes G. Retinal ischemia with neovascularization in cisplatin related retinal toxicity. American Journal of Ophthalmology 2006, 141:196-197.
24. Lawrenson J.G., Kelly C., Lawrenson A.L., Birch J. Acquired colour vision deficiency in patients receiving digoxin maintenance therapy. British Journal of Ophthalmology 2002, 86:1259-1261.
25. Mueller K.P., Schnaedelbach O.D., Russig H.D., Neuhauss S.C. VisioTracker, an innovative automated approach to oculomotor analysis. Journal of Visualized Experiments 2011, (56). (Oct 12). pii: 3556. http://dx.doi.org/10.3791/3556.
26. Neuhauss S.C., Biehlmaier O., Seeliger M.W., Das T., Kohler K., Harris W.A., et al. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. Journal of Neuroscience 1999, 19:8603-8615.
27. Pauly A., Brignole-Baudouin F., Labbe A., Liang H., Warnet J.M., Baudouin C. New tools for the evaluation of toxic ocular surface changes in the rat. Investigative Ophthalmology & Visual Science 2007, 48:5473-5483.
28. Phillips J.B., Blanco-Sanchez B., Lentz J.J., Tallafuss A., Khanobdee K., Sampath S., et al. Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function. Disease Models & Mechanisms 2011, 4:786-800.
29. Plummer R., Wilson R.H., Calvert H., Boddy A.V., Griffin M., Sludden J., et al. A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. British Journal of Cancer 2011, 104:593-598.
30. Redfern W.S., Waldron G., Winter M.J., Butler P., Holbrook M., Wallis R., et al. Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?. Journal of Pharmacological and Toxicological Methods 2008, 58:110-117.
31. Richards F.M., Alderton W.K., Kimber G.M., Liu Z., Strang I., Redfern W.S., et al. Validation of the use of zebrafish larvae in visual safety assessment. Journal of Pharmacological and Toxicological Methods 2008, 58:50-58.
32. Santaella R.M., Fraunfelder F.W. Ocular adverse effects associated with systemic medications: recognition and management. Drugs 2007, 67:75-93.
33. Schmid K.E., Kornek G.V., Scheithauer W., Binder S. Update on ocular complications of systemic cancer chemotherapy. Survey of Ophthalmology 2006, 51:19-40.
34. Taylor K.L., Grant N.J., Temperley N.D., Patton E.E. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell Communication and Signaling 2010, 8:11.
35. Thomas T., Galiani D., Brod R.D. Gentamicin and other antibiotic toxicity. Ophthalmology Clinics of North America 2001, 14:611-624.
36. Verdugo-Gazdik M.E., Simic D., Opsahl A.C., Tengowski M.W. Investigating cytoskeletal alterations as a potential marker of retinal and lens drug-related toxicity. Assay and Drug Development Technologies 2006, 4:695-707.
37. Westerfield M. A guide for the laboratory use of zebrafish (Danio rerio) 2000, University of Oregon Press. 4th ed.
38. Yin J., Shine L., Raycroft F., Deeti S., Reynolds A., Ackerman K.M., et al. Inhibition of the Pim1 oncogene results in diminished visual function. PLoS One 2012, 7:e52177.