Acquired colour vision deficiency in patients receiving digoxin maintenance therapy

British Journal of Ophthalmology

Volumn 86, Issue 11, 2002, Pages 1259-1261

  Lawrenson, J G ^a   Kelly, C ^a   Lawrenson, A L ^b   Birch, J ^a  

^a CITY UNIVERSITY   (United Kingdom)

^b EPSOM GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN;

AGED; ARTICLE; CLINICAL ARTICLE; COLOR VISION DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG BLOOD LEVEL; ELDERLY CARE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RETINA; VISUAL ACUITY;

AGED; AGED, 80 AND OVER; CARDIOTONIC AGENTS; COLOR PERCEPTION TESTS; COLOR VISION DEFECTS; DIGOXIN; FEMALE; HUMANS; MALE;

EID: 0036828268     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.86.11.1259     Document Type: Article

References (23)

1. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525-33.
2. Kelly RA, Smith TW. Recognition and management of digitalis toxicity. Am J Cardiol 1992;69:108G-18G.
3. Beller GA, Smith TW, Abelmann WH, et al. Digitalis intoxication. A prospective clinical study with serum level correlations. N Engl J Med 1971;284:989-97.
4. Williamson KM, Thrasher KA, Fulton KB, et al. Digoxin toxicity: An evaluation in current clinical practice. Arch Intern Med 1998;158:2444-9.
5. Goldstein RL, Stanton BA, Lipson MJ. Clinical utility of serum digoxin level tests in hospitalized elderly patients. Arch Phys Med Rehabil 1986;67:34-7.
6. Fraufelder FT, Fraunfelder FW. Drug-induced Ocular Side Effects. 5th Ed. Boston: Butterworth-Heinemann, 2001.
7. Storstein O, Hansteen V, Hatle L, et al. Studies on digitalis. XIII. A prospective study of 649 patients on maintenance treatment with digitoxin. Am Heart J 1977;93:434-43.
8. Rietbrock N, Alken RG. Color vision deficiencies: A common sign of intoxication in chronically digoxin-treated patients. J Cardiovasc Pharmacol 1980;2:93-9.
9. Lely AH, van Enter CH. Large-scale digitoxin intoxication. BMJ 1970;3:737-40.
10. Manninen V. Impaired colour vision in diagnosis of digitalis intoxication (letter). BMJ 1974;4:653-4.
11. Aronson JK, Ford AR. The use of colour vision measurement in the diagnosis of digoxin toxicity. QJ Med 1980;49:273-82.
12. LeSage JM, Chuman MA. Color vision tests to identify elevated digoxin levels. Res Nurs Health 1986;9:171-7.
13. Haustein KO, Schmidt C. Differences in color discrimination between three cardioactive glycosides. Int J Clin Pharmacol Ther Toxicol 1988;26:517-20.
14. Hobley A, Lawrenson J. Ocular adverse effects to the therapeutic administration of digoxin. Ophthalmic Physiol Opt 1991;11:391-3.
15. Butler VP Jr, Odel JG, Rath E, et al. Digitalis-induced visual disturbances with therapeutic serum digitalis concentrations. Ann Intern Med 1995;123:676-80.
16. Wolin MJ. Digoxin visual toxicity with therapeutic blood levels of digoxin. Am J Ophthalmol 1998;125:406-7.
17. 3H)Digoxin in the optic tract in digoxin intoxication. J Cardiovasc Pharmacol 1980;2:699-706.
18. Weleber RG, Shults WT. Digoxin retinal toxicity. Clinical and electrophysiological evaluation of a cone dysfunction syndrome. Arch Ophthalmol 1981;99:1568-72.
19. Madreperla SA, Johnson MA, Nakatani K. Electrophysiologic and electroretinographic evidence for photoreceptor dysfunction as a toxic effect of digoxin. Arch Ophthalmol 1994;112:807-12.
20. +-ATPase isoforms in the retina. Int Rev Cytol 1992;133:151-85.
21. Burke JM, McKay BS. In vitro aging of bovine and human retinal pigment epithelium: Number and activity of the Na/K ATPase pump. Exp Eye Res 1993;57:51-7.
22. Turner N, Scarpace PJ, Lowenthal DT. Geriatric pharmacology: Basic and clinical considerations. Annu Rev Pharmacol Toxicol 1992;32:271-302.
23. King-Smith PE. In: Foster DH, ed. Inherited and Acquired Colour Vision Deficiencies: Fundamental Aspects and Clinical Studies. Basingstoke, Hants: Macmillan Press, 1991:38-55.