The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening

Biochemical Journal

Volumn 456, Issue 1, 2013, Pages 25-33

  Lai, Ying ^a   Lou, Xiaochu ^a   Jho, Yongseok ^b   Yoon, Tae Young ^c   Shin, Yeon Kyun ^a,d  

^a IOWA STATE UNIVERSITY   (United States)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Bipolar charge distribution; Ca2+ dependent content mixing; Ca2+ independent docking; Linker region; Soluble N ethylmaleimide sensitive fusion protein attachment protein receptor (SNARE); Synaptotagmin 1 (Syt1)

Indexed keywords

CALCIUM ION; DISULFIDE; SYNAPTOTAGMIN I;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; CALCIUM; CATIONS, DIVALENT; CROSS-LINKING REAGENTS; DISULFIDES; LIPIDS; MEMBRANE FUSION; MEMBRANES, ARTIFICIAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; SNARE PROTEINS; STATIC ELECTRICITY; SYNAPTIC VESICLES; SYNAPTOTAGMIN I;

EID: 84886460455     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130949     Document Type: Article

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