Prevention of liver steatosis through fish oil supplementation: Correlation of oxidative stress with insulin resistance and liver fatty acid content

Archivos Latinoamericanos de Nutricion

Volumn 63, Issue 1, 2013, Pages 29-36

  Espinosa, Alejandra ^a   Valenzuela, Rodrigo B ^a   González Mañán, Daniel ^a   Espessailles, Amanda D'T ^a   Gormaz, Juan Guillermo ^a   Barrera, Cynthia R ^a   Tapia, Gladys O ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Docosahexaenoic acid; Eicosapentaenoic acid; Insulin resistance; N 3 fatty acids; Non alcoholic fatty liver disease; Oxidative stress

Indexed keywords

EDIBLE OIL; FISH OIL;

ANIMAL; ARTICLE; C57BL MOUSE; DIET SUPPLEMENTATION; FATTY LIVER; INSULIN RESISTANCE; MALE; METABOLISM; MOUSE; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; DIETARY FATS, UNSATURATED; DIETARY SUPPLEMENTS; FATTY LIVER; FISH OILS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS;

EID: 84886439139     PISSN: 00040622     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bellentani S., Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol. 2009;8:S4-S8.
2. Alberti K. G., Zimmet P., Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet. 2005;366:1059-62.
3. Musso G., Gambino R., Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Progr Lipid Res. 2009;48:1-26.
4. Videla L. A., Rodrigo R., Araya J., Poniachik J. Insulin resistance and oxidative stress interdependency in nonalcoholic fatty liver disease. Trends Mol Med. 2006;12:555-8.
5. Poudyal H., Panchal S. K., Diwan V., Brown L. Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action. Prog Lipid Res. 2011;50:372-87.
6. Valenzuela R., Videla L. A. The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity. Food Funct. 2011;2:644-8.
7. Uauy R., Mena P., Rojas C. Essential fatty acids in early life: structural and functional role. Proc Nutr Soc. 2000;59:3-15.
8. Brenner R. R. Hormonal modulation of Δ6 and Δ5 desaturases: case of diabetes. Prostag Leukotr Ess. 2003;68:151-62.
9. Campoy C., Escolano-Margarit M. V., Anjos T., Szajewska H., Uauy R. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. Br J Nutr. 2012;107:S85-106.
10. Serhan C. H., Petasis N. Resolvins and Protectins in Inflammation Resolution. Chem Rev. 2011;111:5922-43.
11. Mardones M., Valenzuela R., Romanque P., Covarrubias N., Anghileri F., Fernández V., Videla L. A., Tapia G. Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol. J Nutr Biochem. 2012;23:1113-20.
12. Capanni M., Calella F., Biagini M. R., Genise S., Raimondi L., Bedogni G., Svegliati-Baroni G., Sofi F., Milani S., Abbate R., Surrenti C., Casini A. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther. 2006;23:1143-51.
13. Piro S., Spadaro L., Russello M., Spampinato D., Oliveri C. E., Vasquez E., Benigno R., Brancato F., Purrello F., Rabuazzo A. M. Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. Nutr Metab Cardiovasc Dis. 2008;18:545-52.
14. Reznick A. Z., Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 1994;233:357-63.
15. Bligh E. G., Dyer W. J. A rapid method of total lipid extraction and purification. Canadian J Biochem Physiol. 1959;37:911-7.
16. Pettinelli P., Del Pozo T., Araya J., Rodrigo R., Araya A. V., Smok G., Csendes A., Gutierrez L., Rojas J., Korn O., Maluenda F., Diaz J. C., Rencoret G., Braghetto I., Castillo J., Poniachik J., Videla L. A. Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion. Biochim Biophys Acta. 2009;1792:1080-6.
17. Gao L., Wang J., Sekhar K. R., Yin H., Yared N. F., Schneider S. N., Sasi S., Dalton T. P., Anderson M. E., Chan J. Y., Morrow J. D., Freeman M. L. Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem. 2007;282:2529-37.
18. Valenzuela R., Espinosa A., González-Mañán D., D́Espessailles A., Fernández V, Videla L. A., Tapia G. N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis. Plos One. 2012;7:e46400.
19. Bloomer R. J., Larson D. E., Fisher-Wellman K. H., Galpin A. J., Schilling B. K. Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. Lipids Health Dis. 2009;19, 8-36.
20. Tayyebi-Khosroshahi H., Houshyar J., Tabrizi A., Vatankhah A. M., Razzagi Zonouz N., Dehghan-Hesari R. Effects of omega-3 fatty acid on oxidative stress in patients on hemodialysis. Iran J Kidney Dis. 2010;4, 322-26.
21. Romieu I., Garcia-Esteban R., Sunyer J., Rios C., Alcaraz-Zubeldia M., Velasco S. R., Holguin F. The effect of supplementation with omega-3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM (2.5). Environ Health Perspect. 2008;116, 1237-47.
22. Iraz M., Erdogan H., Ozyurt B., Ozugurlu F., Ozgocmen S., Fadillioglu E. Brief communication: omega-3 essential fatty acid supplementation and erytrocytes oxidant/antioxidant status in rats. Ann Clin Lab Sci. 2005;35, 169-73.
23. González-Mañán D., Tapia G., Gormaz J. G., D'Espessailles A., Espinosa A., Masson L., Varela P., Valenzuela A., Valenzuela R. Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils. Food Funct. 2012;3:765-72.