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Volumn 33, Issue 11, 2013, Pages 779-788

Safety of bevacizumab in treating metastatic colorectal cancer: A systematic review and meta-analysis of all randomized clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN;

EID: 84886438384     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-013-0125-6     Document Type: Review
Times cited : (33)

References (38)
  • 1
    • 41349099104 scopus 로고    scopus 로고
    • Cancer statistics, 2008
    • 18287387 10.3322/CA.2007.0010
    • Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96.
    • (2008) CA Cancer J Clin , vol.58 , pp. 71-96
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 84874677879 scopus 로고    scopus 로고
    • Antiangiogenic drugs for colorectal cancer: Exploring new possibilities
    • Ferrarotto R, Hoff PM. Antiangiogenic drugs for colorectal cancer: exploring new possibilities. Clin Colorectal Cancer. 2013;12(1):1-7.
    • (2013) Clin Colorectal Cancer , vol.12 , Issue.1 , pp. 1-7
    • Ferrarotto, R.1    Hoff, P.M.2
  • 3
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • 21296855 10.3322/caac.20107
    • Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
    • (2011) CA Cancer J Clin , vol.61 , Issue.2 , pp. 69-90
    • Jemal, A.1    Bray, F.2    Center, M.M.3
  • 4
    • 79959338988 scopus 로고    scopus 로고
    • Survival for metastatic colorectal cancer in the bevacizumab era: A population-based analysis
    • 21859560 10.1016/j.clcc.2011.03.004 1:CAS:528:DC%2BC3MXhtlKju7nE
    • Renouf DJ, Lim HJ, Speers C, et al. Survival for metastatic colorectal cancer in the bevacizumab era: a population-based analysis. Clin Colorectal Cancer. 2011;10(2):97-101.
    • (2011) Clin Colorectal Cancer , vol.10 , Issue.2 , pp. 97-101
    • Renouf, D.J.1    Lim, H.J.2    Speers, C.3
  • 5
    • 84856625485 scopus 로고    scopus 로고
    • FOLFIRI plus bevacizumab 5 mg/kg versus 10 mg/kg as second-line therapy in patients with metastatic colorectal cancer who have failed first-line bevacizumab plus oxaliplatin-based therapy: A randomized phase III study (EAGLE study)
    • Mishima H, Oba K, Sakamoto J, et al. FOLFIRI plus bevacizumab 5 mg/kg versus 10 mg/kg as second-line therapy in patients with metastatic colorectal cancer who have failed first-line bevacizumab plus oxaliplatin-based therapy: a randomized phase III study (EAGLE study). Jpn J Clin Oncol. 2012;42(2):134-8.
    • (2012) Jpn J Clin Oncol , vol.42 , Issue.2 , pp. 134-138
    • Mishima, H.1    Oba, K.2    Sakamoto, J.3
  • 6
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • 18421054 10.1200/JCO.2007.14.9930 1:CAS:528:DC%2BD1cXlvFaqs7g%3D
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26(12):2013-9.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 7
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • 18854571 10.1200/JCO.2008.16.3212 1:CAS:528:DC%2BD1MXhslCmtw%3D%3D
    • Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008;26(33):5326-34.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 8
    • 66149120036 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study
    • 19406901 10.1093/annonc/mdp233
    • Van Cutsem E, Rivera F, Berry S, et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol. 2009;20(11):1842-7.
    • (2009) Ann Oncol , vol.20 , Issue.11 , pp. 1842-1847
    • Van Cutsem, E.1    Rivera, F.2    Berry, S.3
  • 9
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • 15175435 10.1056/NEJMoa032691 1:CAS:528:DC%2BD2cXks1Gjt74%3D
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-42.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 10
    • 33646783722 scopus 로고    scopus 로고
    • National Cancer Institute
    • National Cancer Institute (2006). Common terminology criteria for adverse events v3.0 (CTCAE). http://ctep.cancer.gov/protocolDevelopment/electronic- applications/docs/ctcaev3.pdf. Accessed 19 Dec 2011.
    • (2006) Common Terminology Criteria for Adverse Events v3.0 (CTCAE)
  • 11
    • 79960980997 scopus 로고    scopus 로고
    • Risk of arterial thromboembolic events in patients with advanced colorectal cancer receiving bevacizumab
    • 21273347 10.1093/annonc/mdq702 1:STN:280:DC%2BC3MfisVahsg%3D%3D
    • Tebbutt NC, Murphy F, Zannino D, et al. Risk of arterial thromboembolic events in patients with advanced colorectal cancer receiving bevacizumab. Ann Oncol. 2011;22(8):1834-8.
    • (2011) Ann Oncol , vol.22 , Issue.8 , pp. 1834-1838
    • Tebbutt, N.C.1    Murphy, F.2    Zannino, D.3
  • 12
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • 15738537 10.1200/JCO.2005.05.112 1:CAS:528:DC%2BD2MXlslWntr0%3D
    • Kabbinavar F, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol. 2005;23(16):3697-705.
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3697-3705
    • Kabbinavar, F.1    Schulz, J.2    McCleod, M.3
  • 13
    • 78649978359 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with advanced cancer: A meta-analysis of randomized controlled trials
    • Geiger-Gritsch S, Stollenwerk B, Miksad B, et al. Safety of bevacizumab in patients with advanced cancer: a meta-analysis of randomized controlled trials. Oncologist. 2010;15(11):1179-91.
    • (2010) Oncologist , vol.15 , Issue.11 , pp. 1179-1191
    • Geiger-Gritsch, S.1    Stollenwerk, B.2    Miksad, B.3
  • 14
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • 8721797 10.1016/0197-2456(95)00134-4 1:STN:280:DyaK28zgvVCmug%3D%3D
    • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12.
    • (1996) Control Clin Trials , vol.17 , Issue.1 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 15
    • 0024991175 scopus 로고
    • Some statistical methods for combining experimental results
    • 2361819 10.1017/S0266462300008916 1:STN:280:DyaK3c3pvFGktg%3D%3D
    • Laird NM, Mosteller F. Some statistical methods for combining experimental results. Int J Technol Assess Health Care. 1990;6(1):5-30.
    • (1990) Int J Technol Assess Health Care , vol.6 , Issue.1 , pp. 5-30
    • Laird, N.M.1    Mosteller, F.2
  • 16
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • 12958120 10.1136/bmj.327.7414.557
    • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3
  • 17
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • 3802833 10.1016/0197-2456(86)90046-2 1:STN:280:DyaL2s7gsVamtA%3D%3D
    • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • Dersimonian, R.1    Laird, N.2
  • 20
    • 56649123212 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis
    • 19017914 10.1001/jama.2008.656 1:CAS:528:DC%2BD1cXhtlyrt77O
    • Nalluri SR, Chu D, Keresztes R, et al. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA. 2008;300(19):2277-85.
    • (2008) JAMA , vol.300 , Issue.19 , pp. 2277-2285
    • Nalluri, S.R.1    Chu, D.2    Keresztes, R.3
  • 21
    • 77951262917 scopus 로고    scopus 로고
    • Short time infusion of bevacizumab in combination with 5fu-based chemotherapy as first-line therapy in a non-selective patient group with metastatic colorectal cancer
    • 20001495 10.3109/02841860903428184 1:CAS:528:DC%2BC3cXkvVagu70%3D
    • Dohn LH, Jensen BV, Larsen FO. Short time infusion of bevacizumab in combination with 5fu-based chemotherapy as first-line therapy in a non-selective patient group with metastatic colorectal cancer. Acta Oncol. 2010;49(3):395-6.
    • (2010) Acta Oncol , vol.49 , Issue.3 , pp. 395-396
    • Dohn, L.H.1    Jensen, B.V.2    Larsen, F.O.3
  • 22
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • 12506171 10.1200/JCO.2003.10.066 1:CAS:528:DC%2BD2cXpsVWru7Y%3D
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol. 2003;21(1):60-5.
    • (2003) J Clin Oncol , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 23
    • 84857951632 scopus 로고    scopus 로고
    • Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: A systematic review and meta-analysis, with emphasis on chemotherapy subgroups
    • 22414244 10.1186/1471-2407-12-89 1:CAS:528:DC%2BC38Xot1Gis7Y%3D
    • Macedo LT, Lima A, Sasse AD. Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: a systematic review and meta-analysis, with emphasis on chemotherapy subgroups. BMC Cancer. 2012;12:89.
    • (2012) BMC Cancer , vol.12 , pp. 89
    • Macedo, L.T.1    Lima, A.2    Sasse, A.D.3
  • 24
    • 77954008527 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systematic review
    • 19942597 10.1093/annonc/mdp533 1:STN:280:DC%2BC3czmsFSqsg%3D%3D
    • Welch S, Spithoff K, Rumble RB, et al. Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: a systematic review. Ann Oncol. 2010;21(6):1152-62.
    • (2010) Ann Oncol , vol.21 , Issue.6 , pp. 1152-1162
    • Welch, S.1    Spithoff, K.2    Rumble, R.B.3
  • 25
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • 15867200 10.1200/JCO.2005.00.232 1:CAS:528:DC%2BD2MXlslWntro%3D
    • Kabbinavar FF, Hambleton J, Mass RD, et al. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 2005;23(16):3706-12.
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3
  • 26
    • 24344442899 scopus 로고    scopus 로고
    • Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
    • 16118771 10.1002/jso.20301 1:CAS:528:DC%2BD2MXhtVGltrnK
    • Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol. 2005;91(3):173-80.
    • (2005) J Surg Oncol , vol.91 , Issue.3 , pp. 173-180
    • Scappaticci, F.A.1    Fehrenbacher, L.2    Cartwright, T.3
  • 27
    • 78649941418 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 22 Oct 2010
    • European Medicines Agency. Avastin (bevacizumab): European public assessment report (EPAR). http://www.emea.europa.eu/docs/en-GB/document-library/ EPAR-Summary-for-the-public/human/000582/WC500029260.pdf. Accessed 22 Oct 2010.
    • Avastin (Bevacizumab): European Public Assessment Report (EPAR)
  • 28
    • 67649201009 scopus 로고    scopus 로고
    • Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer
    • 19382200 10.1002/cncr.24305 1:CAS:528:DC%2BD1MXotFOgsr4%3D
    • Jackson NA, Barrueco J, Soufi-Mahjoubi R, et al. Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer. Cancer. 2009;115(12):2617-29.
    • (2009) Cancer , vol.115 , Issue.12 , pp. 2617-2629
    • Jackson, N.A.1    Barrueco, J.2    Soufi-Mahjoubi, R.3
  • 29
    • 77955497309 scopus 로고    scopus 로고
    • Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group randomized phase III MAX study
    • 20516443 10.1200/JCO.2009.27.7723 1:CAS:528:DC%2BC3cXpslajtL0%3D
    • Tebbutt NC, Wilson K, Gebski VJ, et al. Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group randomized phase III MAX study. J Clin Oncol. 2010;28(19):3191-8.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3191-3198
    • Tebbutt, N.C.1    Wilson, K.2    Gebski, V.J.3
  • 30
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
    • 15908660 10.1200/JCO.2005.10.017 1:CAS:528:DC%2BD2MXlsVyhsrs%3D
    • Hurwitz HI, Fehrenbacher L, Hainsworth JD, et al. Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. J Clin Oncol. 2005;23(15):3502-8.
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3502-3508
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Hainsworth, J.D.3
  • 31
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group study E3200
    • 17442997 10.1200/JCO.2006.09.6305 1:CAS:528:DC%2BD2sXlsVyntbc%3D
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group study E3200. J Clin Oncol. 2007;25(12):1539-44.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 32
    • 58249088835 scopus 로고    scopus 로고
    • Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
    • 19064978 10.1200/JCO.2008.17.7931 1:CAS:528:DC%2BD1MXhvVKrsb0%3D
    • Kabbinavar FF, Hurwitz HI, Yi J, et al. Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol. 2009;27(2):199-205.
    • (2009) J Clin Oncol , vol.27 , Issue.2 , pp. 199-205
    • Kabbinavar, F.F.1    Hurwitz, H.I.2    Yi, J.3
  • 33
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • 19144677 10.1634/theoncologist.2008-0213 1:CAS:528:DC%2BD1MXjt1Clt7o%3D
    • Hurwitz HI, Yi J, Ince W, et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist. 2009;14(1):22-8.
    • (2009) Oncologist , vol.14 , Issue.1 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3
  • 34
    • 70349690209 scopus 로고    scopus 로고
    • Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer: First BEAT and the randomised phase-III NO16966 trial
    • 19789532 10.1038/sj.bjc.6605259 1:CAS:528:DC%2BD1MXhtF2lu7rL
    • Okines A, Puerto OD, Cunningham D, et al. Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer: First BEAT and the randomised phase-III NO16966 trial. Br J Cancer. 2009;101(7):1033-8.
    • (2009) Br J Cancer , vol.101 , Issue.7 , pp. 1033-1038
    • Okines, A.1    Puerto, O.D.2    Cunningham, D.3
  • 35
    • 59249096067 scopus 로고    scopus 로고
    • Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients
    • 19152449 10.3748/wjg.15.449 1:CAS:528:DC%2BD1MXisVSmt7s%3D
    • Moehler M, Sprinzl MF, Abdelfattah M, et al. Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients. World J Gastroenterol. 2009;15(4):449-56.
    • (2009) World J Gastroenterol , vol.15 , Issue.4 , pp. 449-456
    • Moehler, M.1    Sprinzl, M.F.2    Abdelfattah, M.3
  • 36
    • 77951907727 scopus 로고    scopus 로고
    • A phase i study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors
    • 19940012 10.1093/annonc/mdp489 1:STN:280:DC%2BC3c%2FlvVamtw%3D%3D
    • Sharma S, Abhyankar V, Burgess RE, et al. A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors. Ann Oncol. 2010;21(2):297-304.
    • (2010) Ann Oncol , vol.21 , Issue.2 , pp. 297-304
    • Sharma, S.1    Abhyankar, V.2    Burgess, R.E.3
  • 37
    • 79952307340 scopus 로고    scopus 로고
    • Randomized phase II trial of adjuvant hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancer
    • 21189384 10.1200/JCO.2010.32.5977 1:CAS:528:DC%2BC3MXktlelsb8%3D
    • Kemeny NE, Jarnagin WR, Capanu M, et al. Randomized phase II trial of adjuvant hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancer. J Clin Oncol. 2011;29(7):884-9.
    • (2011) J Clin Oncol , vol.29 , Issue.7 , pp. 884-889
    • Kemeny, N.E.1    Jarnagin, W.R.2    Capanu, M.3
  • 38
    • 84871720057 scopus 로고    scopus 로고
    • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomized phase 3 trial
    • 23168366 10.1016/S1470-2045(12)70477-1 1:CAS:528:DC%2BC3sXhsV2gug%3D%3D
    • Bennouna J, Sastre J, Arnold D, et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomized phase 3 trial. Lancet Oncol. 2013;14(1):29-37.
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 29-37
    • Bennouna, J.1    Sastre, J.2    Arnold, D.3


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